David J [email protected]

Microvascular Erasure in Long COVID and Spike Protein Exposure: Complementary Mechanisms of Direct Cellular Injury and Perfusion Impairment Driving Capillary Rarefaction 🚨Spike protein may be erasing your capillaries. New proposal claims LongC0VID’s core problem is irreversible microvascular destruction, not just inflammation. →Structural + functional rarefaction up to 18 months post-inf! ➡️Interesting international evidence-based hypothesis model, a research proposal builds on existing science/literature! ➡️Bear with me…. their hypothesis: 1. Persistent capillary rarefaction is a core hallmark of LongC0VID, detectable up to 18 months post-infection, with studies showing ~45% loss of the smallest capillaries and reduced microvascular health scores. 2. They propose two complementary, interacting mechanisms of “microvascular erasure” driven by SARSCoV2 spike protein exposure: A. STRUCTURAL rarefaction (irreversible physical vessel loss) via direct endothelial and pericyte injury: calcium dysregulation, mitochondrial dysfunction, ACE2/RAS imbalance, NF-κB inflammation, eNOS uncoupling (BH4 depletion), ferroptosis, NETs/DAMPs, senescence, and autoantibodies. B. FUNCTIONAL rarefaction (perfusion failure in remaining vessels) via amyloid fibrin microclots, NET-immunothrombosis, platelet activation, pericyte constriction, and RBC deformability issues. 3. These create a vicious cycle of patchy hypoxia, tissue ischemia, fibrosis, and organ dysfunction (brain fog, fatigue, cardiac issues, etc.), potentially progressing to an acquired systemic sclerosis-like state (“Spike Protein Endothelial Disease” or SPED). 4. Reinfection/vaccination: The document does not discuss reinfections or present any data on vaccination. It only proposes future studies to correlate capillary density with vaccination history and spike exposure. No mechanisms or comparisons between natural infection versus vaccine-derived spike are detailed. ➡️This proposal synthesizes prior evidence on persistent capillary rarefaction and spike-mediated endothelial injury into a unified “microvascular erasure” framework, distinguishing structural from functional damage and introducing the "SPED concept". Its bolder interpretive synthesis offers a coherent, hypothesis-generating model that indeed should merit further testing. ‼️So, following the authors, capillary rarefaction in LongC0VID represents not a temporary dysfunction but progressive, largely irreversible microvascular erasure. Once structural vessel loss occurs, downstream parenchyma is permanently orphaned in non-regenerative tissues (heart, brain, kidney), locking patients into chronic hypoxia and multi-organ decline. Spike-driven mechanisms turn a single exposure into a self-perpetuating disease process with “scleroderma-like” features, a sobering prospect of widespread, potentially permanent microvascular obliteration if unaddressed.🤔 Would greatly appreciate @resiapretorius thoughts? #AvoidSars2 #AvoidReinfections researchgate.net/profile/Abd…