Andrew Penn (@ACPenn6) header
Andrew Penn (@ACPenn6) profile picture

Andrew Penn

@ACPenn6

Research interests include glutamate receptors and excitatory synapses in health and disease

 University of Sussex, UK
sussex.ac.uk/lifesci/pennlab/index
Joined January 2019
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Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)Photo by Andrew Penn (@ACPenn6)
A new paper from our lab reveals the effect of gain- and loss-of-function GluN2B mutations on synaptic function. The differences in NMDA-EPSCs mediated by synaptic GluN1/2B mutants are lost when the mutated subunits assemble with GluN2A into triheteromers mdpi.com/2076-3425/12/6/789/…
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Prince William's night at the pub with Carole Middleton. #royal To read Thursday's Eden Confidential column in full, click on this link via @MailOnline google.com/amp/s/www.dailyma…
Image from Richard Eden (@richardaeden)
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Ian Coombs (@IanDCoombs) profile picture
Ian Coombs@IanDCoombs16 Mar 2024
1. @uclnpp had an inspiring day with @CureGrin on 2nd March @IOE_London, hosting their latest #MeetandGRI event. Over 100 patients, families and researchers gathered to exchange knowledge and drive forward research at the UK’s largest ever GRI disorder meeting!
Image from Ian Coombs (@IanDCoombs)
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📗#IINSpublication | "Synapse specific and plasticity-regulated #AMPAR mobility tunes synaptic integration" The scientists used combining #molecular tools and high-resolution imaging to resolve pre- and post-synaptic contributions to short-term #plasticity biorxiv.org/content/10.1101/…
Image from Interdisciplinary Institute for Neuroscience 🧠 (@iins_bordeaux)
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lpwlab (@LonnieWollmuth) profile picture
lpwlab@LonnieWollmuth19 Sep 2023
authors.elsevier.com/a/1hnTy… Our paper is finally out addressing the complexity of loss- and gain-of-function in NMDARs. Intense and great effort by the authors!! @NeuroMoodyG
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Ingo Greger (@igreger1) profile picture
Ingo Greger@igreger113 Sep 2023
First Cryo-EM structures of homomeric GluA1 AMPA glutamate receptor reveals functional roles for N-terminal domains www2.mrc-lmb.cam.ac.uk/first… rdcu.be/dl34q
First Cryo-EM structures of homomeric GluA1 AMPA glutamate receptor reveals functional roles for...

First Cryo-EM structures of homomeric GluA1 AMPA glutamate receptor reveals functional roles for...

Electron cryo-microscopy structures of GluA1 AMPA receptors from Ingo Greger’s group in the LMB’s Neurobiology Division reveals that previously unseen struc ...

mrclmb.ac.uk
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I'm so proud of my PhD student Ella Bates, for passing her viva earlier today. What a wonderful occasion, congratulations Ella!
Image from Andrew Penn (@ACPenn6)
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Nice to see this one hit the press Ingo, congratulations!
Ingo Greger (@igreger1) profile pictureIngo Greger@igreger122 Mar 2023
Our latest work an AMPA receptor/TARP therapeutics now published - congrats to all involved, prospective students interested to continue this get in touch!
Image from Ingo Greger (@igreger1)
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Apply now! 38th Microelectrode Techniques for Cell Physiology Workshop, 30 August – 13 September 2023 Marine Biological Association, Plymouth, UK mymba.mba.ac.uk/ems-event-bo… 🔬🐌🪰🪱🦑🦞🧬
Course poster

ALT Course poster

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Ingo Greger (@igreger1) profile picture
Ingo Greger@igreger127 Sep 2022
Towards a mechanism of TARP gamma8-selective AMPA receptor therapeutics. Surprisingly, these drugs not only exhibit negative allosteric modulation but also act as positive modulators, depending on receptor subtype and TARP-gamma8 stoichiometry! @cryoEM biorxiv.org/content/10.1101/…
Image from Ingo Greger (@igreger1)
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lpwlab (@LonnieWollmuth) profile picture
lpwlab@LonnieWollmuth25 Sep 2022
I think I am now an official zebrafish PI. 4th publication with zebrafish (and a fifth on the way). Beautiful work by graduate student Josiah Zoodsma (twitterless I believe). If only we could convince him to stay another year or two. Talented he is. molecularautism.biomedcentra…
Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish

Molecular Autism - Autism spectrum disorder (ASD), like many neurodevelopmental disorders, has complex and varied etiologies. Advances in genome sequencing have identified multiple candidate genes...

link.springer.com
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lpwlab (@LonnieWollmuth) profile picture
lpwlab@LonnieWollmuth3 Jul 2022
Hosting iGluR2022 this August (1st to 3rd) in Stony Brook ion-channelconferences.org/.
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Deadline extended until 8th July for this funded PhD position in my lab at @SussexNeuro !
Miguel Maravall (@MMaravall) profile pictureMiguel Maravall@MMaravall6 Jun 2022
New funded PhD in my lab to work on a really exciting question: how does sensory cortex process task-related information during natural behaviour? Mouse exploration/decision making, behaviour tracking, 2p imaging or wireless electrophys… 30th Jun deadline bit.ly/SussexWhiskersPhD
Image from Miguel Maravall (@MMaravall)
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Kevin Staras (@KStaras) profile picture
Kevin Staras@KStaras16 Jun 2022
A big favour: my 14 yo devised & wrote a free+ad-free game (GROAK) 100% by himself. He just put it on Google Play: shorturl.at/cfFG7 He’s hoping for 100 downloads - so far just 10. If you like word games, pls try it, & make his day! Thanks for any RTs and nice reviews! 1/3
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New publication of Nelson Rebola's lab and @PaolettiLab is out @NeuroCellPress! 1/3 cell.com/neuron/fulltext/S08…
GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits

Bossi et al. show that GluN3A subunits control the activity of selective neuronal populations in the adult mouse brain via the formation of excitatory glycine GluN1/GluN3A receptors (eGlyRs)....

cell.com
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Our results demonstrate that functional incorporation of GluN2B mutants into synaptic receptors and the effects on NMDA-EPSC decay times are highly dependent on their co-assembly with GluN2A into triheteromeric GluN1/2A/2B receptors.
Image from Andrew Penn (@ACPenn6)
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To find out more, you can find our article by following the link below: mdpi.com/2076-3425/12/6/789/… Thank you to all coauthors (@marwaelmasri7, @OGSteele et al), our collaborator Kasper Hansen, to @The_MRC and @SussexLifeSci, to colleagues at @SussexNeuro, and to @BrainSci_MDPI.
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