Pharmacologist and electrophysiologist working at UCL
Colchester, England
Joined August 2017
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Excited to start my new role as Lecturer @uclnpp! Big plans for student-centered research next year 🐸. Kicking things off today with a lecture on sustainability in lab science @SustainableUCL. Let's go!
📷📷📷📷📷📷
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1. @uclnpp had an inspiring day with @CureGrin on 2nd March @IOE_London, hosting their latest #MeetandGRI event. Over 100 patients, families and researchers gathered to exchange knowledge and drive forward research at the UK’s largest ever GRI disorder meeting!
3. Many thanks to all of the contributors. In particular it was a huge honour to share a stage with @keithmcarthur, @m_farrant, @igreger1, Katherine Roche, @GRIN_tx, @a_mctague, @KBGenesBrains, Jessica Martin, @biocns, @ACPenn6, @s_schorge.
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Sensational work on #GRIA3 Disorder by @AllanBayat, Berardo Rinaldi, Anders Kristensen and colleagues. An excellent blueprint for future studies on genetic diseases of the AMPA receptors.
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Delighted to share our open-access paper on #GRIA3, an X-linked neurodevelopmental disorder.
Before this paper, females were considered healthy carriers & limited data was available on affected males. What we found, was pretty cool...👇
#Morbidgene
academic.oup.com/brain/artic…
Ian Coombs retweeted
Live with @AllanBayat at #IEC2023, to talk about his call for patients with rare disorders in 4 genes : #GRIA1, #GRIA2, #GRIA3, #GRIA4 🧬🔎
Find out more: epi-care.eu/collaborative-ge… and share to help advance #epilepsyresearch!
#rareepilepsy #raredisease
Ian Coombs retweeted
#Methane is a potent greenhouse gas. A strain of bacteria has been found that eats methane even when it is present at relatively low concentrations. By 2050, the microbe could keep 240 million tons of methane out of the atmosphere. In PNAS: ow.ly/YaW550PCtgx
ALT Round petri dishes with pale gray bacterial colonies growing on them like polka dots. Colonies of Methylotuvimicrobium buryatense growing on methane on an agar plate. CREDIT: Lian He
Ian Coombs retweeted
The way this snail bridges the gap
📹@pTeLaNOGHRtRPQ6
nitter.gq/pTeLaNOGHRtRPQ6/status…
The final version of our latest paper is now available:
doi.org/10.7554/eLife.66765 @eLife
We demonstrate a clear benefit of using NASPM intracellularly, rather than spermine, to identify the calcium-permeability of synaptic AMPARs - auxiliary subunits no longer confuse the issue.
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Incredibly pleased, proud and honored to be awarded a GRI Patient Impact Award at the @CureGRIN conference 2023! What an amazing few days engaging with scientists, clinicians, families, and, of course, patients.
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Ian Coombs retweeted
congrats to @IanDCoombs and the farrant/cull-candy lab in @uclnpp and @uclbiosciences for their paper in elife! they describe an improved functional approach to identify the presence of the important calcium-permeable form of AMPA-type glutamate receptor: doi.org/10.7554/eLife.66765
Some New Year's resolutions can be found here!
A very nice piece from Imperial College's Grantham Institute about how we can all help the planet in 2023 and beyond.
imperial.ac.uk/stories/clima…
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Ian Coombs retweeted
Excellent talks on #GRINpathies by Natalia Julia and @stephane_auvin 👏👏
Natalia showed that L-Serine should be considered in #GRIN LOF disease, whereas Stephane showed that #Radiprodil is a promising treatment option for patients with #GRIN2B GOF disease‼️
#PrecisionMedicine
Our first feelgood foray into translational research: Perampanel can be therapeutic for patients with overactive GRIA variants.
Half the length of the first submission, but I still like it and it takes less time to read... @CureGrin @JulieZiobro @uclnpp
onlinelibrary.wiley.com/doi/…
Yet more exceptional structural and functional work from the @igreger1 laboratory, this time on TARP g8-selective drugs. Congrats!
biorxiv.org/content/early/20…
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Wordle 462 1/6
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Never shared wordle before, but this happened on the way back from the pub this morning.
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An altogether more delicious source of our favourite proteins:
Purification and biochemical analysis of native AMPA receptors from three different mammalian species biorxiv.org/content/10.1101/…
