@AndyShih_Lab

Neuroscientist, sorting out the brain's plumbing in health and disease.

 Seattle, Washington
theshihlab.com
Joined February 2021
  • Tweets224
  • Following489
  • Followers1.8K
34Media
Happy to see this work finally published 🙌!! A team effort with @AndyShih_Lab!! We show that from birth to old age, #microglia 🧠 undergo striking shifts in morphology, complexity, and injury response. #liveimaging #neuroimmune #neonatalbrain #agingbrain
Cell Reports@CellReports16 Jul 2025
Physiological and injury-induced microglial dynamics across the lifespan dlvr.it/TLxvmH

Physiological and injury-induced microglial dynamics across the lifespan

Tieu, T. et al. leveraged in vivo two-photon live imaging of microglia, the brain’s resident immune cells, to reveal striking differences in their morphology, basal dynamics, and injury responses...

cell.com
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Groundbreaking scientific discoveries don’t happen in isolation. Michelle Gray, PhD, SfN Program Committee member, shares how you can enhance your research through valuable exchange w/ the scientific community at #SfN25. Submit your abstract today! 🔗 bit.ly/4juLSLs
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This mini review was a fun one for @sosamariaj and I where we dove into the mysteries of brain perivascular fibroblasts! Thank you to @AndyShih_Lab for guidance on this one! Please enjoy 😊! frontiersin.org/articles/10.…

Frontiers | The elusive brain perivascular fibroblast: a potential role in vascular stability and...

In the brain, perivascular fibroblasts (PVFs) reside within the perivascular spaces (PVSs) of arterioles and large venules, however their physiological and p...

frontiersin.org
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MARK YOUR CALENDAR: The @dfg_public CRC1366 will host the "Vascular Control of Organ Function" meeting in Mannheim in May 2024. Exciting program with diverse contributions from different fields of angiocrine research. Registration will open in October at SFB1366.de .
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We team up with @drew_lab_nvc to examine anatomical and functional changes in aged mouse brain. We found that aging induces selective regional vascular and pericyte degeneration, slowed NVC response, and lower oxygen carrying capacity. biorxiv.org/content/10.1101/…

Aging drives cerebrovascular network remodeling and functional changes in the mouse brain

Aging is the largest risk factor for neurodegenerative disorders, and commonly associated with compromised cerebrovasculature and pericytes. However, we do not know how normal aging differentially...

biorxiv.org
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Andy Shih retweeted
Nick Klug@Nrklug23 Feb 2023
We examined the time course of constriction to pressure. Arterioles and transition zone vessels constricted rapidly to an increase in tissue pressure. Where distal (thin strand) pericytes took much longer (5+ minutes), sound familiar @AndyShih_Lab ? Mechanisms still unclear!
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Our new article in Nature Aging is now published online. We reported an age-related decrease in responsivity of brain micro vessels, accompanied by a decrease in vessel density and loss of vascular mural cell processes. @lundbeckfonden @neuroscience_dk nature.com/articles/s43587-0…

Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict...

Nature Aging - Frailty of the aged brain may relate to impaired vascular control and limitations in energy supply. The authors report an age-related decrease in responsivity of brain microvessels,...

nature.com
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Our paper is out! nature.com/articles/s41467-0… With genetic Ca2+ clamping and chemogenetic activation of astrocytes, we show that astrocytes enhance neurovascular coupling when neuronal activation is sustained but not when activation is brief.
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If you are interested in blood flow changes in cerebral vessels due to developmental #pericyte deficency here is link to our recent publication- journals.sagepub.com/doi/10.… Thank you @JillStobart and Bruno Weber's lab! 🍾🥂

Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency -...

Pericytes are the mural cells of the microvascular network that are in close contact with underlying endothelial cells. Endothelial-secreted PDGFB leads to recr...

journals.sagepub.com
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Our neurovascular mapping paper @CellReports shows striking correlation between vascular network/pericyte and cortical neuronal cell types in mice. doi.org/10.1016/j.celrep.202…. Congrats @YuanTingWu1 @HannahCBennett7 @Qingguang_Zhang @drew_lab_nvc
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Our lab’s first preprint is online! Mechanisms underlying calcium signaling in capillary pericytes. Proud of this work from our first student, Braxton Phillips, and including important contributions from Jenna Clark and Eric Martineau! biorxiv.org/content/10.1101/…

Store-Operated Ca2+ Channels Mediate Microdomain Ca2+ Signals and Amplify Gq-Coupled Ca2+ Elevati...

Pericytes are multifunctional cells of the vasculature that are vital to brain homeostasis, yet many of their fundamental physiological properties remain unexplored. Ca2+ is a ubiquitous second...

biorxiv.org
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KCNJ8/ABCC9-containing K-ATP channel modulates brain vascular smooth muscle development and neurovascular coupling . Great collaboration led by @betsholtz and Koji Ando sciencedirect.com/science/ar…
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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research | @stemcellreports #COVID19 #vascular #pericytes #endothelial doi.org/10.1016/j.stemcr.202…
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Liver-secreted fluorescent blood plasma markers enable chronic imaging of microcirculation doi.org/10.1101/2022.04.08.4… A single i.p. AAV injection labels the blood plasma with green (or red) FP for at least several months. I hope this is useful for many people's future work.
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Check out our work. Just published in @CircRes! Piezo1 is a Mechanosensor Channel in Central Nervous System Capillaries ahajournals.org/doi/10.1161/… [🧵⬇️]
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"Of all gray matter astrocytes, 99.8% are connected to at least one blood vessel" 👉 sciencedirect.com/science/ar…! Very elegant work by #brunoweber group!
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Replying to @astrecyte
Congrats!!!! 👏 – at Seattle, WA
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Our new paper is out in @NeuroCellPress! 1/4🧵
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Our new paper by Császár, Lénárt et al., is out in @JExpMed showing that #microglia modulate cerebral blood flow, neurovascular coupling and adaptation to hypoperfusion via dynamic, purinergic actions in the #NVU. rupress.org/jem/article/219/…
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Here comes the first publication of our SNSF funded CoVasc consortium (while I am home fighting Omicron) - very proud of you guys and this comprehensive summary. COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences frontiersin.org/article/10.3…

Frontiers | COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in December 2019 as a novel respiratory pathogen and is the causative agent...

frontiersin.org
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