French Research lab led by Dr. Cyrille Botté with major focus on lipid synthesis/trafficking/signalling and metabolism in Toxoplasma, malaria, infectious agents
IAB Uni Grenoble Alpes France
Joined September 2019
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We are excited to share our latest work: #toxoplasma #lipin channels the flux of host lipids between #lipid storage and membrane biogenesis for division, preventing #lipotoxicity. Superb work @sheena_dass @ParaFrap @Serenashun@IFCPAR all the team! nature.com/articles/s41467-0…
Glad to share this collaborative nice collaborative study we particitated to from @RitaTewari 's lab about the role of SUN1-ALLAN in nuclear envelope and MTOC organisations in Plasmodium #malaria.
Delighted to share our new study on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @Zeeshan_MF; @EelcoTromer ; @RyujiYanase; @TonyHolder2; Sarah; David F; Akancha; Igor; Cyrille; Robert; Declan. @KarineLeRoch1; Link:
biorxiv.org/content/10.1101/…
Proud to be @Gemeli_official . Thanks to all our partners for their constant support and for the official inauguration of the platform today
Après le dévoilement de la plaque inaugurale par les partenaires, Visites commentées par les responsables scientifiques des 3 instruments de la plateforme GEMELI sur le site du @CHU_Grenoble et sur le campus santé de l’@UGrenobleAlpes.
Glad to share our latest study on #Toxoplasma #lipid synthesis and trafficking in @jlipidres
We reveal the role of a novel #AcylCoAsynthetase aka Fatty acid metabolic activator. Great work by the team, especially @sheena_dass, @Serenashun @charital_sarah
shorturl.at/GBFgb
We show that TgACS3 is responsible for activating and channeling the constant flux of scavenged fatty acids towards parasite lipid storage #lipiddroplets,allowing mobilization of membrane building blocks for parasite division and survival especially under high host nutrient level
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Shame and terrible idea from @NIAIDFunding for a shutting down one of the most powerful and successful database, which we use daily! This will not only waste #scientificfunding from and in the USA but also from all international fundings schemes too...Keep the data available!!
It appears #NIAID will shutter the genome data base we all use daily. This strikes me as a significant mistake that may well endanger much of our global progress. @BSPparasitology @AS_Para @ASTMH @TrendsParasitol @AmSocParasit @parasitesrule @PiParasitology
We are having a blast of science fun and great food/moments together. Thanks heapsto all our speakers and funders for such an excpetional moment. Thanks heaps @IFCPAR, @cnrs, @inserm, @ICGEBNewDelhi, @IAB_Officiel, @UGrenobleAlpes , @auvergnerhalpes
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Just back from Berlin for the #Toxo2024, we had a blast of science and fun!! Viele Danke to the organizers and bravo to our #toxo #lipid afficionados @charital_sarah @NyamekyeQuansa1 and Amandine Lourdel for their great work and presentations #proudPI
Auf wiedersehen!!
Glad to share our latest study in @mbiojournal on #toxo fatty acid activation by an acyl-CoA synthetase that relocates to peroxisomal structure in extracellular parasites under low host nutrient content to allow parasite motility by fueling #betaoxidation
rb.gy/cuftf3
Happy to share new insights about Plasmodium mitochondrial PhospholipaseA2 blood stage role: it degrades PG to generate LBPA and fatty acids for parasite mb biogenesis. Great work by @serenashun @MitchQuansah etal. and nice collaboration with @Pradel_Lab t.ly/b1KuO
Great collaborative work between @ApicoLipid @Gemeli_official @IBS_Grenoble out in @ScienceAdvances . Congrats to all all! Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet | Science Advances science.org/doi/10.1126/scia…
Great times of science, advances and perspectives on infectious diseases,malaria toxo. Many thanks to @IFCPAR @ICGEBNewDelhi @UGrenobleAlpes @IAB_Officiel @INSB_CNRS @cnrs @CNRSinIndia @ifiofficiel to support cooperation & student exchanges between our labs in France and India
Many thanks to @DBTIndia @IndiaDST @sup_recherche without whom support and exchanges wouldn't be possible
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Great work from @SanchezSyrian and @s_besteiro (@parafrap!) showing the the relict plastid or apicoplast of Toxoplasma is essential for the survival of the dormant life stages (silent and incurable) of the parasite! New treatment possibilities ahead!
So happy to see that @SanchezSyrian's main PhD work is now out in @PNASNews. Nice collaboration with Nico Blanchard's team @InfinityTLS!
pnas.org/doi/abs/10.1073/pna…
A nice collaboration between @ILLGrenoble @ApicoLipid and @Gemeli_official using systematic #lipidomic quantification of #deuterated #lipids to produce advanced models of #synthetic #biologicalmembranes from natural lipid for biophysical characterization. authors.elsevier.com/c/1h3VV…
And a new Dr was born! Dr @CS_Arnold !!! After a brillant Thesis, @CS_Arnold treated us with a superb defense on #toxoplasma #lipid #trafficking. Thx for your work, maturity,enthusiasm! Thx to jury member @SoldatiLabToxo @Arctas_fr Fred. Domergue Fran Giordano @mercier_corinne
Thanks again to @ClareHardingLab with her PhD student @AghabiDana from @UofGlasgow who came to treat us @IAB_Officiel with some great #iron #trafficking in #toxoplasma science and discussion here in Grenoble. (Grenoble had to pay back with a some food and #chartreuse of course!)
It's just out! Very glad to share our latest collaborative #malaria project with the @ICGEBNewDelhi team of Asif Mohmmed in @CellReports . Lysophopholipase3 generates fatty acid from host #lipid,stored and timely mobilized for parasite division +MMV drugs shorturl.at/dszU9
We tagged and localized lysophopholipase3(LPL3) at #hostparasite interfaces within the host erythrocytes. Inducible KO shows that LPL3 is essential for #schizogony and progeny formation
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Nice collaboration with the @SaeijlabUCDavis, glad that we and @Gemeli_official could help contributing identifying the #toxoplasma molecular effectors involved in #Parasite fitness under interferon gama stimultation. Congrats to the team!
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Thanks to our speakers @IAB_Officiel who treated us with plenty of #parasitedata for our "@cefipra-LIA IRP @CNRSinOceania Infectious diseases meeting" @SheinerLab , Prof Malcolm McConville from @Bio21Institute @UniMelb , Dr Asif Mohmmed and Pawan Malhotra from @ICGEBNewDelhi 👏
Congratulations to brand new Dr shunmugam @Serenashun for a brillant defense and amazing work on #lipid in #apicomplexa #parasites(more soon)Bravo Serena! Big shout out to the amazing jury @HAKIMIMohamedA1, @SheinerLab Prof Malcolm McConville, Dr Olivier Epaulard and Dr Yamaryo!
Also big thx for the support for Serena's thesis @IAB_Officiel @IFCPAR @UGrenobleAlpes @FRM_officiel @INSB_CNRS @CNRSinASEAN @Inserm @auvergnerhalpes
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Having a great and stimulating @ParaFrap #EMBO meeting so far! Very proud of our @apicolipid #lipid afficionados @Serenashun (eonderful talk!!), @CS_Arnold @charital_sarah @MitchQuansah (super posters!) who are doing a great job and enjoying their time! #greatscience #proudPI
