Axelrod Lab (@AxelrodLab) header
Axelrod Lab (@AxelrodLab) profile picture

Axelrod Lab

@AxelrodLab

Laboratory for chemical synthesis and bioorganic chemistry applied to problems in immunology and oncology. @purduechemistry @purdue_mcmp

 West Lafayette, IN
chem.purdue.edu/axelrod/
Joined February 2018
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Congratulations to Charles Enlow and Zhichen Ma for passing their doctoral defense exams! Dr^2!
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Check out some great methodology from the @agr_chemistry #RRL13
a. g. roberts chemistry (@agr_chemistry) profile picturea. g. roberts chemistry
@agr_chemistryApr 24
please check out our cover art and latest strategy to synthesize pyrido[n]helicenes! @joc_ol @ACSpublications @agr_chemistry @utahchemistry @uutah pubs.acs.org/doi/10.1021/acs…
Image from a. g. roberts chemistry (@agr_chemistry)
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A spectacular synthesis from the @MingjiDai group!
Mingji Dai (@MingjiDai) profile pictureMingji Dai@MingjiDaiApr 15
Our conidiogenone B total synthesis is hot off the press @J_A_C_S! Cheers! @jo5i3bee @EmoryChem Seven-Step Total Synthesis of Conidiogenone B Enabled by Radical Cyclizations | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Seven-Step Total Synthesis of Conidiogenone B Enabled by Radical Cyclizations

Seven-Step Total Synthesis of Conidiogenone B Enabled by Radical Cyclizations

Abstract. We report herein a total synthesis of conidiogenone B, a complex cyclopiane diterpene exhibiting potent antibacterial activity against multidrug-

pubs.acs.org
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Some really fantastic chemistry from the @MingjiDai group!
Mingji Dai (@MingjiDai) profile pictureMingji Dai@MingjiDai25 Aug 2025
In our total synthesis of psathyrin A fresh @J_A_C_S, we challenged the MHAT radical chemistry to build four-membered ring and it worked! Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization

Total Synthesis of (−)-Psathyrin A Enabled by Radical Cyclization

Abstract. We report herein an enantioselective total synthesis of (−)-psathyrin A, an antibacterial diterpene natural product possessing a unique 6/4/5/5 t

pubs.acs.org
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Axelrod Lab retweeted
Tony Iommi (@tonyiommi) profile picture
Tony Iommi
@tonyiommi22 Jul 2025
I just can’t believe it! My dear dear friend Ozzy has passed away only weeks after our show at Villa Park.  It’s just such heartbreaking news that I can’t really find the words, there won’t ever be another like him. Geezer, Bill and myself have lost our brother. My thoughts go out to Sharon and all the Osbourne family. Rest in peace Oz. Tony
Image from Tony Iommi (@tonyiommi)
Image from Tony Iommi (@tonyiommi)
Image from Tony Iommi (@tonyiommi)
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Another outstanding paper from the @Townsend_Lab
Nat. Prod. Reports (@NatProdReports) profile pictureNat. Prod. Reports@NatProdReports13 Mar 2025
🔓Be sure to read this #OpenAccess review by Julie A. Talbert & Steven D. Townsend @Townsend_Lab @VanderbiltChem discussing how human milk is a complex natural product mixture Find their full article on our website👇 pubs.rsc.org/en/content/arti…
Human milk as a complex natural product

Human milk as a complex natural product

Covering: up to the end of 2024 Breastfeeding is one of the most effective ways to promote child health. However, characterizing the chemistry that fortifi

pubs.rsc.org
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Tremendous congratulations!
Eurocarb22 (@eurocarb22) profile pictureEurocarb22@eurocarb2226 Feb 2025
📢 For the first time in history, the Emil Fischer Award will be presented to two outstanding scientists! 🏆👏 At @Eurocarb22, the awardees are: 🔬 Sabine FLITSCH (University of Manchester, UK) 🔬 Carmen GALAN (University of Bristol, UK) Congratulations! 🎉
Image from Eurocarb22 (@eurocarb22)
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If you like carbohydrates and glycosylations check out our organocatalytic glycosylation now out in @ChemCommun! pubs.rsc.org/en/content/arti…
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pubs.rsc.org/en/content/arti… Major congratulations to all the authors on their work!
Isothiourea – catalyzed α-selective glycosylations†

Isothiourea – catalyzed α-selective glycosylations†

Herein, we present a catalytic strategy to efficiently form both α-1,2-cis and α-1,2-trans glycosyl linkages from either glycosyl bromide or chloride donor

pubs.rsc.org
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Check this out - it should be fantastic!
Alexei Demchenko, PhD, ACSF (@glycoworld) profile pictureAlexei Demchenko, PhD, ACSF@glycoworld4 Nov 2024
I'll be presenting From Stereocontrolled Glycosylation to Automated Chemical Synthesis at Thieme Cheminars on 12 Nov cassyni.com/events/PCCEqoQzH…
Emerging Trends in Glycoscience, Part #2

Emerging Trends in Glycoscience, Part #2

Carbohydrates are essential biomolecules with significant roles in chemistry, biology, and medicine. The "Emerging Trends in Glycoscience" issue highlights advancements in synthetic carbohydrate...

cassyni.com
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Stop by the ACS Carbohydrate Young Investigators Symposium (or tune in via the interwebs) to see our work on organocatalytic glycosylations. It should be sweet!
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Fantastic work @MingjiDai - way to go!
Mingji Dai (@MingjiDai) profile pictureMingji Dai@MingjiDai29 Jul 2024
Please check out our crinipellin synthesis @J_A_C_S ! Special thanks to @TantilloLab for the DFT calculations! Concise Total Syntheses of (−)-Crinipellins A and B Enabled by a Controlled Cargill Rearrangement | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Abstract. Herein, we report concise total syntheses of diterpene natural products (−)-crinipellins A and B with a tetraquinane skeleton, three adjacent all

pubs.acs.org
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Axelrod Lab retweeted
Mingji Dai (@MingjiDai) profile picture
Mingji Dai@MingjiDai29 Jul 2024
Please check out our crinipellin synthesis @J_A_C_S ! Special thanks to @TantilloLab for the DFT calculations! Concise Total Syntheses of (−)-Crinipellins A and B Enabled by a Controlled Cargill Rearrangement | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Abstract. Herein, we report concise total syntheses of diterpene natural products (−)-crinipellins A and B with a tetraquinane skeleton, three adjacent all

pubs.acs.org
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Fantastic work @MingjiDai - congratulations!
Mingji Dai (@MingjiDai) profile pictureMingji Dai@MingjiDai6 Jun 2024
Here is our collaborative work with @KhannaLabUF! C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of...

C–H Functionalization-Enabled 11-Step Semisynthesis of (−)-Veragranine A and Characterization of...

Abstract. We report an efficient semisynthesis of the cholestane steroidal alkaloid (−)-veragranine A with a 6/6/6/5/6/6 hexacyclic ring system, eight ster

pubs.acs.org
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Tremendous achievement - congratulations to all!
Xuefei Huang (@Xuefei_lab) profile pictureXuefei Huang@Xuefei_lab26 Apr 2024
It took more than four years. But we got there with a new carbohydrate based vaccine against S. aureus including drug resistant strains. Grateful for the hard work by our group members and collaborators. chemistry.msu.edu/news/2024-…

A vaccine to fight antibiotic resistance

MSU, Harvard Medical School team up to expand vaccine science’s role in the fight against MRSA and other infections

chemistry.msu.edu
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Since Ag2O-mediated activation was introduced by German chemists Koenigs and Knorr, and “cooperatively catalyzed” is Kooperativ Katalysiert in German, we @Glycoworld refer to this new reaction as “the 4K reaction.”
CarbohydrateResearch (@CarbohydrateRes) profile pictureCarbohydrateResearch@CarbohydrateRes28 Mar 2024
The 4K reaction dlvr.it/T4kNxD
Image from CarbohydrateResearch (@CarbohydrateRes)
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Check this synthesis out!
Chemistry at Thieme (@thiemechemistry) profile pictureChemistry at Thieme
@thiemechemistry4 Mar 2024
Replying to @MingjiDai
@MingjiDai and his co-workers @EmoryUniversity report the total synthesis of complanadine A using a pyrrole-to-pyridine #molecularediting strategy 👉brnw.ch/21wHxxP #totalsynthesis #skeletalediting #alkaloids #ringexpansion
Image from Chemistry at Thieme (@thiemechemistry)
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Here is some fantastic work coming out of the @agr_chemistry laboratory - check it out!
a. g. roberts chemistry (@agr_chemistry) profile picturea. g. roberts chemistry
@agr_chemistry6 Feb 2024
our research on lasso peptide isomers was highlighted by @hartsockwendy in the February @BoulderPeptide journal club! thank you, Wendy. @UtahChemistry @UUtah pubs.acs.org/doi/full/10.102… boulderpeptide.org/2024/02/0…
Nonthreaded Isomers of Sungsanpin and Ulleungdin Lasso Peptides Inhibit H1299 Cancer Cell Migration

Nonthreaded Isomers of Sungsanpin and Ulleungdin Lasso Peptides Inhibit H1299 Cancer Cell Migration

Abstract. Lasso peptides are a structurally distinct class of biologically active natural products defined by their short sequences with impressively inter

pubs.acs.org
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Fantastic work!
Mingji Dai (@MingjiDai) profile pictureMingji Dai@MingjiDai16 Jan 2024
We are happy to start the Year of 2024 with a total synthesis of heilonine @J_A_C_S ! Cheers! Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C–H Functionalizations | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C–H Functionalizations

Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C–H Functionalizations

Abstract. We report a convergent and efficient total synthesis of the C-nor D-homo steroidal alkaloid (+)-heilonine with a hexacyclic ring system, nine ste

pubs.acs.org
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Big congratulations to 3rd year Charles Enlow on passing his qualifying exam!
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