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Axelrod Lab (@AxelrodLab) profile picture

Axelrod Lab

@AxelrodLab

Laboratory for chemical synthesis and bioorganic chemistry applied to problems in immunology and oncology. @purduechemistry @purdue_mcmp

 West Lafayette, IN
chem.purdue.edu/axelrod/
Joined February 2018
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Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)Photo by Axelrod Lab (@AxelrodLab)
Axelrod Lab retweeted
Tony Iommi (@tonyiommi) profile picture
Tony Iommi
@tonyiommi22 Jul 2025
I just can’t believe it! My dear dear friend Ozzy has passed away only weeks after our show at Villa Park.  It’s just such heartbreaking news that I can’t really find the words, there won’t ever be another like him. Geezer, Bill and myself have lost our brother. My thoughts go out to Sharon and all the Osbourne family. Rest in peace Oz. Tony
Image from Tony Iommi (@tonyiommi)
Image from Tony Iommi (@tonyiommi)
Image from Tony Iommi (@tonyiommi)
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Axelrod Lab retweeted
Mingji Dai (@MingjiDai) profile picture
Mingji Dai@MingjiDai29 Jul 2024
Please check out our crinipellin synthesis @J_A_C_S ! Special thanks to @TantilloLab for the DFT calculations! Concise Total Syntheses of (−)-Crinipellins A and B Enabled by a Controlled Cargill Rearrangement | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Concise Total Syntheses of (−)‑Crinipellins A and B Enabled by a Controlled Cargill Rearrangement

Abstract. Herein, we report concise total syntheses of diterpene natural products (−)-crinipellins A and B with a tetraquinane skeleton, three adjacent all

pubs.acs.org
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Since Ag2O-mediated activation was introduced by German chemists Koenigs and Knorr, and “cooperatively catalyzed” is Kooperativ Katalysiert in German, we @Glycoworld refer to this new reaction as “the 4K reaction.”
CarbohydrateResearch (@CarbohydrateRes) profile pictureCarbohydrateResearch@CarbohydrateRes28 Mar 2024
The 4K reaction dlvr.it/T4kNxD
Image from CarbohydrateResearch (@CarbohydrateRes)
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Axelrod Lab retweeted
Shenvi Lab (@Shenvi_Lab) profile picture
Shenvi Lab@Shenvi_Lab23 Aug 2023
Happy Birthday to the original pioneer in supernatural products and fabulous colleague, Dale @BogerLab⁩. This post is a day late, but his science is 20 years ahead of its time, so that makes us about even. Best wishes to a great colleague and friend.
Image from Shenvi Lab (@Shenvi_Lab)
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Axelrod Lab retweeted
Steve Sucheck (@SteSuch) profile picture
Steve Sucheck@SteSuch22 Jun 2023
Thank you for your support Glyoscience community. Also a big thank you and congrats to @MCGalan_Bristol Looking forward to working on this together #glycotime
Alexei Demchenko, PhD, ACSF (@glycoworld) profile pictureAlexei Demchenko, PhD, ACSF@glycoworld22 Jun 2023
My heartiest congratulations to @MCGalan_Bristol and @SteSuch who were elected to co-chair the 2027 Gordon Research Conference on Carbohydrates. @acs_carb #glycotime
Image from Alexei Demchenko, PhD, ACSF (@glycoworld)
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the Stevens rearrangement remains useful for the synthesis of polycyclic natural products, check out the review @MylesLovasz, @ValitonChelsea, and Zach Schwartz wrote in SYNTHESIS @thiemechemistry: thieme-connect.com/products/… @UtahChemistry @UUtah
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structures like this are why more orthogonal peptide cyclization methods are needed, awesome medicinal chemistry optimization
Dani Schultz (@danithechemist) profile pictureDani Schultz@danithechemist27 Aug 2022
mRNA display makes billions of macrocyclic peptides in one round (🤯) - dramatically impacting drug discovery. @ACSMedChemLett highlights Merck’s PCSK9 inhibitor which is the first clinical candidate from this technology! pubs.acs.org/doi/10.1021/acs…
Image from Dani Schultz (@danithechemist)
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1/2. We are looking for postdocs with a strong synthetic streak who take pride in a successful purification and structure elucidation, have independent ideas, are passionate about research, and can advise and train junior graduate students.
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A fantastic presentation on “Chemistry Innovation and Biological Discovery Through Natural Product Total Synthesis” by Professor Mingji Dai! ⁦@ACSorganic⁩ #NOS2022 ⁦@MingjiDai⁩
Image from Angie R Angeles (@angierangeles)
Image from Angie R Angeles (@angierangeles)
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For a Synlett @thiemechemistry account I am writing, I needed a reference to what people had to do before Weinreb amide. I mentioned this old H. C. Brown work in my talks (the “chemistry lore”), but only now managed to retrieve the reference. I find the comments interesting.
Image from Andrei Yudin (@andrei_yudin)
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I am honored to announce that I will join the University of Pennsylvania this summer as a PIK Professor. penntoday.upenn.edu/news/dir…
Dirk Trauner appointed Penn Integrates Knowledge University Professor | Penn Today

Dirk Trauner appointed Penn Integrates Knowledge University Professor | Penn Today

Trauner, one of the world’s most innovative interdisciplinary chemists, will have joint appointments in the School of Arts & Sciences and in the Perelman School of Medicine.

penntoday.upenn.edu
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Ralph M. Steinman was born #OTD. He won a #LaskerAward for his discovery of how #DendriticCells work in the immune system. #immunology @RockefellerUniv ow.ly/CFRD30mTqXF
Image from Lasker Foundation (@LaskerFDN)
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Postdoc position is open immediately to study lipid-protein interactions in metabolism at Purdue University. This position will be co-mentored by Drs. Greg Henderson and Rob Stahelin. #postdoc #lipid #protein
Image from Stahelin Lab (@Stahelin_Lab)
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Allen Bard — known around the world as “the father of modern electrochemistry” — is stepping down after a 63-year career in @UTChemistry at #UTAustin. Enjoy your well-deserved retirement! cns.utexas.edu/news/electroc…
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September 9th 4:00 p.m. RHPH 164
Image from Purdue Borch MCMP (@Purdue_MCMP)
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We ❤️ all of our #MSKHealthcareHeroes, but our four-legged volunteers have an extra special place in our hearts. 🐶 This #NationalDogDay, meet some of the #MSKCaringCanines who bring joy and comfort to our patients and staff with more than 8,000 visits per year! 🦮🐕‍🦺
Image from Memorial Sloan Kettering Cancer Center (@MSKCancerCenter)
Image from Memorial Sloan Kettering Cancer Center (@MSKCancerCenter)
Image from Memorial Sloan Kettering Cancer Center (@MSKCancerCenter)
Image from Memorial Sloan Kettering Cancer Center (@MSKCancerCenter)
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Axelrod Lab retweeted
Altmaniacs (@Altmaniacs) profile picture
Altmaniacs@Altmaniacs25 Aug 2021
Jacob's review in @thiemechemistry, is now available online. Here, he summarizes "fluorine-retentive" reactions of gem-difluorinated alkenes that provide products bearing a CF2 group. rb.gy/cjris5
Gem-difluoroalkenes commonly undergo defluorination reactions to generate mono-fluorinated products or fluorine addition reactions to generate CF3 products. In this review, Jacob summarizes "fluorine-retentive" reactions that provide products bearing a CF2 group.

ALT Gem-difluoroalkenes commonly undergo defluorination reactions to generate mono-fluorinated products or fluorine addition reactions to generate CF3 products. In this review, Jacob summarizes "fluorine-retentive" reactions that provide products bearing a CF2 group.

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Our lab @SloanKettering is actively recruiting postdocs interested in #chemicalbiology and #inflammasomes. Contact me directly for more information. Please retweet – thank you! mskcc.org/research/ski/labs/…
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Frederick Sanger was born #OTD. He received a #LaskerAward in 1979 for the development of a technique for the rapid sequencing of #DNA. #SangerSequencing ow.ly/HJPm30li56H
Image from Lasker Foundation (@LaskerFDN)
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Looking for a postdoc that gives you experience with DNA-encoded chemistry? Join us in the Krusemark lab! #jobopportunity #DELs #postdocjobs jobrxiv.org/job/purdue-unive…
Postdoctoral Scientist in DNA-encoded Medicinal Chemistry

Postdoctoral Scientist in DNA-encoded Medicinal Chemistry

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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