The All of Us program announced earlier this week a new data release from 747,000 participants, including: 👉 535,000 whole-genome sequences 👉 Electronic health record data from 482,000 participants 👉 Combined proteomics and transcriptomics from ~8,000 participants 👉 Fitbit wearable data from 68,000 participants This is already the world's largest genomic resource integrated with longitudinal clinical data, surpassing resources such as FinnGen and UK Biobank. It's remarkable to think that the program launched only in May 2018 and has already generated a resource of this scale, contributing to more than 1,000 publications. Importantly, as with all longitudinal population resources, its value is likely to compound over time as additional follow-up datapoints from each participant accumulate. Building, expanding, and enriching foundational resources like All of Us is one of the highest-return investments we can make in biomedical research.

Great new genomic resources for inflammatory bowel disease (IBD) from the International IBD Genetics Consortium 1⃣The largest to date IBD GWAS in 125,992 cases & 1.2M controls showing 619 independent signals at 420 IBD regions accounting for 77–80% (!) of SNP-based heritability