#celltherapy $BMY #Sjogrens rheumatologist via @hopkinsmedicine, @HarvardMed, @MIT_HST, @jhrheumatology, @MGHrheumatology, @harvardstemcell
Boston
Joined May 2012
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My graphic of how #stemcells can serve as niches for daughter cells. #science @Nature bit.ly/1LOr9OV
Brandon Law, M.D. retweeted
Evidence for lymph node organs in unsuspected places of the body keeps emerging. Now with the artery to promote autoimmunity and accelerate atherosclerosis. An auto-antibody titer (anti-H2B) predicts thoracic artery calcification in people, at least as well as LDL cholesterol. nature.com/articles/s44161-0…
Brandon Law, M.D. retweeted
Ways to reinvigorate the physical exam in medicine
Step 1. Do the exam. No "WNL"—we never looked
nejm.org/doi/full/10.1056/NE…
Another demonstration of the importance of studying target tissue. We had found a clonal T cell population in the skin (and not found in the blood) in this complicated case of anti-synthetase syndrome.
This case report describes the clinical course of a 32-year-old woman with anti-synthetase syndrome presenting with angioedema-like panniculitis and subsequently cutaneous ulcers, synovitis, and fevers, found to have a clonal TCR-beta gene rearrangement. ja.ma/4alsJqz
Brandon Law, M.D. retweeted
Register for January's "State of #Sjogren's" Updates by the @SjogrensOrg
tinyurl.com/yrmp9ks4 medspoke.co/taps/7770
Brandon Law, M.D. retweeted
.@harvardmed @mit_hst ➡️ broad curriculum reform #Health #Sciences #Technology
To train students committed to becoming #PhysicianScientists, curriculum ➡️ focus on goal to inspire patient-centered #innovation & integration of clinic & scientific inquiry
hms.harvard.edu/news/remakin…
Words of wisdom for those wanting to start a lab👇
I only started my lab a little over 4y ago as an Instructor @harvardmed @MGHHeartHealth with a new K08 award in hand.
4 R01 awards as PI later, here's what I've learned as a physician-scientist:
Fantastic job @wilfredo_nk !
"To find answers, @BalazsLab collaborated with a team that included the lead author of the @CellCellPress paper, @wilfredo_nk, a clinical pathology resident at @MGHPathology / @MassGeneralNews and a clinician-scientist fellow at the @ragoninstitute."
🌐: massgeneral.org/news/press-r…
Brandon Law, M.D. retweeted
#ACR21 Rheumatology Secrets & Pearls: @JKolfenbach & Dr. Stone 📚
Unique Pearls Discussed ⬇️
🩺 Auscultate bruits on the back
💊 Oxypurinol levels
🍓 Strawberry-like gingivitis
👃 Human neutrophil elastase (HNE)
♥️ Coronary aneurysm in IgG4-RD
@ACRheum #ACRAmbassador
Brandon Law, M.D. retweeted
Congratulations Andrew Ewald on being appointed director of the Department of Cell Biology at @HopkinsMedicine hopkinsmedicine.org/news/new…
Brandon Law, M.D. retweeted
The vasculitis of #COVID19.
thelancet.com/journals/lanrh… @TheLancetRheum
Unique features w/ mimics that account for multi-organ involvement, clotting, and pulmonary vascular immunothrombois. A very insightful review/perspective
Brandon Law, M.D. retweeted
Not seeing our loved ones, not being able to be together or embrace each other, is incredibly hard. I know people are frustrated. But we need your patience just a little while longer. Your 9-1-1 call is being answered.
Brandon Law, M.D. retweeted
We've assumed once scar (fibrosis) formed in an organ, it would be too late to reverse it. But science has deconstructed this process and it may turn out to be treatable. A beautiful review today @nature
nature.com/articles/s41586-0… @EdinburghUni's N Henderson, @IBD_FloMD Thomas Wynn
Brandon Law, M.D. retweeted
This summer, we partnered with the clinical team of an immunosuppressed patient with recurrent COVID and multiple hospitalizations. His NP swab VL reached 1 billion copies 5 months after initial dx. The team's Q: is this pt being re-infected w/ COVID? 1/ nejm.org/doi/full/10.1056/NE…
Brandon Law, M.D. retweeted
Collaborative work from our group and others at the NIH and beyond. Introducing VEXAS, a new disease hiding out in patients diagnosed with relapsing polychondritis, polyarteritis nodosa, giant cell arteritis, Sweet Syndrome, MDS, and multiple myeloma! nejm.org/doi/full/10.1056/NE…
Brandon Law, M.D. retweeted
As promised, here’s an overview of our study to find host factors required for SARS-CoV-2 infection in human cells. We use a genome-wide CRISPR screen to identify genes (& key mechanisms) that might be therapeutically targetable to prevent viral infection.
Brandon Law, M.D. retweeted
🚨🚨Here’s the big piece I’ve been promising: an Atlantic cover story about the US’s catastrophic mishandling of the pandemic. It’s a full autopsy of what went wrong, every unattended weakness & unheeded warning, every festering wound & reopened scar. 1/
theatlantic.com/magazine/arc…
Brandon Law, M.D. retweeted
Now online @CellCellPress: Regulatory #Tcells in the colon are transmitted across generations by maternally transferred #IgA. This multigenerational #transmission may modulate the tuning of gut #immune responses and inflammatory #disease susceptibility. bit.ly/2T2xEaS
Echoing data from South Korea, data from Iceland shows that #COVID19 prevalence is much higher in young adults (where testing is widespread and not symptom-driven). We'll need more testing, including serologic testing, before easing restrictions. Thx @alexandreafonso for graphic!
Thank you @chefjoseandres and @WCKitchen for the N95 masks! You’ve been an inspiration for us!
800 N95 masks from @WCKitchen delivered to @JohnsHopkins Hospital in Baltimore...Amazing to meet the women&men on the front lines...The true heroes of our time!!
Brandon Law, M.D. retweeted
Sad. Dr. John Murray of @UCSF defined Acute Respiratory Distress Syndrome (ARDS). Yesterday he died of it due to #COVID19 complications buff.ly/33KGBtv