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Canals Lab

@Canals_Lab

Assistant Professor at UZH and Kispi Zurich. Neuroscientist combining iPSCs and genome editing to model human neurodegenerative Lysosomal Storage Disorders.

 Zürich, Switzerland
kispi.uzh.ch/en/forschungszentrum/neurodegenerative-lysosomal-storage-disorders
Joined September 2020
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  • Followers241
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Photo by Canals Lab (@Canals_Lab)Photo by Canals Lab (@Canals_Lab)Photo by Canals Lab (@Canals_Lab)
It’s a great pleasure to share our latest paper on the impact of oxidative stress on newly emerging hematopoietic cells 🧫 Thanks to everyone who contributed, and made it possible. Out now in @jbiolchem 👉 sciencedirect.com/science/ar…
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Happy to have contributed to this study. Wonderful consortium with excellent science, collaboration and people! Congratulations to everyone involved!!
Lukas Valihrach (@LukasValihrach) profile pictureLukas Valihrach@LukasValihrach27 Sep 2024
🎉Excited to share our latest paper in @GLIA_Journal led by my brilliant student @ZMatusova, in collaboration with amazing international partners!🌍 📄 Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease onlinelibrary.wiley.com/doi/… @IBT_CAS @BIOCEV_science
Image from Lukas Valihrach (@LukasValihrach)
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🎉Excited to share our latest paper in @GLIA_Journal led by my brilliant student @ZMatusova, in collaboration with amazing international partners!🌍 📄 Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease onlinelibrary.wiley.com/doi/… @IBT_CAS @BIOCEV_science
Image from Lukas Valihrach (@LukasValihrach)
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What fuels a lifetime of discovery? Prof. Olle Lindvall, a jubilee doctor at @lunduniversity and pioneer in brain repair, reflects on 50 years of neuroscience. Discover his journey from student to neuroscientist and his advice for future researchers ⤵️ stemcellcenter.lu.se/article…

What fuels a lifetime of scientific discovery? Olle Lindvall reflects on his journey in neuroscience

Lund University. Olle Lindvall’s early academic interests did not suggest a future in neuroscience. “Before I took my high school exams," he recalls, "Biology was not on my radar. I was more intere...

stemcellcenter.lu.se
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Next up at #OpenScienceWeek2024 is @bwmol, who will talk about scientific integrity concerns. There are many things that can go wrong in scientific publishing. Clinical trials usually follows certain guidelines - comparing standard treatments to an experimental treatment.
Image from Elisabeth Bik (@MicrobiomDigest)
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Another week another #assembloid system
ACS Nano (@acsnano) profile pictureACS Nano@acsnano20 Sep 2024
Biocompatible two-photon polymerization (TPP) #3D-printed meshed vessels facilitate the dimensional breaking growth of #BrainOrganoids and multiregional #assembloids. #OpenAccess: go.acs.org/aWh
TOC image from the article

ALT TOC image from the article

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And today we could finally start cell lab work in our new iPSC culture room!
Image from Canals Lab (@Canals_Lab)
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Great news!
URPP ITINERARE (@itinerare_uzh) profile pictureURPP ITINERARE@itinerare_uzh13 Sep 2024
Yay! We are overjoyed to announce that the #UZH Universität Zürich has approved the next funding period for the URPP ITINERARE! Thank you all for making this possible!
Image from URPP ITINERARE (@itinerare_uzh)
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Great to have joined the excellent scientific community at ZNZ and present the work our lab does in the ZNZ symposium!
Image from Canals Lab (@Canals_Lab)
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We're hiring a Research Assistant to join our collaborative team! Gain hands-on training in human stem cells and explore the genetic & molecular basis of neurodegenerative and neurodevelopmental diseases. Please share! If you’re interested send your cv to [email protected]
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And since it's #FluorescenceFriday we'd love to share a beautiful image of iPSC-derived astrocytes featured in our new preprint (Green = GFAP, Red = S100B, Blue = DAPI)! Image credit: talented PhD student @alexlish47 😎
Image from Young-Pearse Lab (@YoungPearseLab)
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It's been 6 years that we developed our iAs protocol @AhleniusHenrik and it is really rewarding to see it being used in such an amazing work!
bioRxiv Neuroscience (@biorxiv_neursci) profile picturebioRxiv Neuroscience@biorxiv_neursci31 Jul 2024
Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's ... biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Replying to @AhleniusHenrik @Frenkez
TODAY: Visit poster 224 to chat with Oskar Zetterdahl ( joint PhD student with @Canals_Lab ) about tagging SNCA in iPSCs for tracking aggregation in LSDs
Image from Henrik Ahlenius (@AhleniusHenrik)
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The lab will be at #ISSCR2024. Check out our posters: number 224, 377 and 571. Also, feel free to reach out if you want to chat about reprogramming, disease modeling or anything astrocytes. See you soon!!
Image from Henrik Ahlenius (@AhleniusHenrik)
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If you want to know the outcome of your prime editing experiment before you even conducted the experiment, visit pridict.it Congrats to Nicolas and many thanks to all collaborators @krauthammerlab @bvansteensellab
Nature Biotechnology (@NatureBiotech) profile pictureNature Biotechnology
@NatureBiotech21 Jun 2024
Machine learning prediction of prime editing efficiency across diverse chromatin contexts go.nature.com/3VQNmq9
Image from Nature Biotechnology (@NatureBiotech)
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Replying to @AdrianoAguzzi
Really happy to read that Adriano!
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Replying to @AdrianoAguzzi
I just saw this Adriano. I am very sorry and I hope you will have a very fast recovery. My best wishes.
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📢 Hey there, researchers! While you're enjoying that coffee, why not take 5 minutes to share your publishing journey in our quick survey? Help us crack the code of academic publishing 🎲☕ #PeerReview Please share this with your friends and colleagues! gukennczi05.typeform.com/to/…

A short survey on Academic Publishing

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gukennczi05.typeform.com
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Post-Doc opportunity! Interested in cellular reprogramming as a therapeutic option? Join the Bengzon lab in collaboration with us @Lund_Stem to develop Astrocyte reprogramming as a treatment for brain tumors. Apply here: fens.org/careers/job-market/… #postdoc #LundSCC #LUCC
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