Hacking pancreatic cancer and anti-tumor immunity @WhiteheadInst. Valhalla Fellow. @Arsenal FC fanatic.
Cambridge, MA
Joined May 2009
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Tobiloba Oni retweeted
#PCAMChat24 A3: From a clinical/translational standpoint, we finally have drugs that can target KRAS in #PancreaticCancer. This gene is abnormal in >90% of cases, and it has taken four decades since the original discovery tofinally have a slew of drugs in the pipeline that can block aberrant KRAS function in patients. However, we also know that these drugs in and of themselves will not be effective and so a lot of preclinical (a.k.a. laboratory based, in experimental models) studies are ongoing looking at effective combinations that can sustain responses longer in patients, while ameliorating toxicities.
Tobiloba Oni retweeted
“There are not, and will never be, KRAS inhibitors” 👀
@Pasca_Lab presents a memorable reviewer comment from her 1st unfunded NIH grant at #AACRPan24.
The lesson is that you should not let deflating reviewer comments define the value of your science. Also, persistence!
Tobiloba Oni retweeted
The company ran a 240 patient (!) randomized phase 2 trial of Simtuzumab in #PancreaticCancer that showed no therapeutic benefit.
academic.oup.com/oncolo/arti…
As an angiogenesis inhibitor (versus the stated inhibition of LOXL2 catalytic activity) this was essentially a rerun of Gem plus Bev trial which had already failed years prior. Really infuriating.
Ever wondered why @gilead's Simtuzumab (Anti-LOXL2 antibody) failed in IPF? Prof Jones & @UHSFT team provide the answer - it does NOT inhibit LOXL2!!
Really cool paper & model - and important lesson for #CurPF4All community! #MustRead #WhyDrugsFail
doi.org/10.1016/j.xcrm.2024.…
Tobiloba Oni retweeted
Glyco enthusiasts from MIT (including Chemistry Professors Laura Kiessling, Barbara Imperiali, and Matt Shoulders) and beyond recently gathered in Bartos Theatre to enjoy presentations of the latest advancements in glycobiology research.
chemistry.mit.edu/chemistry-…
Tobiloba Oni retweeted
I ask for your help to support this Turkey Earthquake Fund gofundme.com/f/xh8d5t-turkey… that will directly help affected families in the region. Thanks everyone who reached out during these difficult times, truly appreciate and will never forget your support ❤️ Please share this 🙏
Tobiloba Oni retweeted
Agreed. I’ve always thought that cancer is when cellular fitness becomes dominant over organismal fitness.
Tobiloba Oni retweeted
For an overarching theme I propose "Reneging on a contract that balances cellular and organismal fitness."
Tobiloba Oni retweeted
💯 Incidentally, I recently talked about this very issue in a podcast (~ 6min mark):
youtu.be/iyGBHvFEYug
Tobiloba Oni retweeted
I consider it a disease of progressive tissue dysregulation that leads to eventual systemic failure. But I draw heavily from @TuftsUniversity Drs. Soto and Sonnenschein “TOFT” theory which IMO is by far the best explanation I’ve seen yet:
ncbi.nlm.nih.gov/pmc/article…
Tobiloba Oni retweeted
I usually define it as cell selfishness, in which individual cells evolve to become independent from the rest, but taking advantage of the shared resources.
Tobiloba Oni retweeted
A mutation+evolution driven state of enhanced fitness/robustness relative to its normal counterpart (at the cellular or tissue level). This happening at such an incredibly accelerated and uncoordinated manner at the expense of the host.
Tobiloba Oni retweeted
A reversion from multicellular, diploid, sexual reproduction to unicellular, diploid, asexual reproduction. Metastasis, dormancy, and other cancer behaviors are best explained by evoluationary theory applied to individual cells residing the environment of the body.
Tobiloba Oni retweeted
Not a cancer biologist. Life requires putting the clamps on entropy. Cancer is what occurs when those restraints are broken.
Tobiloba Oni retweeted
Sometimes research takes scientists to unexpected places, even alpaca farms. Learn how alpaca antibodies have become an important part of pancreatic cancer research in the Oni lab.
wi.mit.edu/news/harnessing-i… @MITbiology @scienceMIT @CancerHacker
Tobiloba Oni retweeted
You never know where science might take you.
In his search to discover ways to harness our natural defenses to combat cancer, KI affiliate fellow Tobi Oni found himself on an alpaca farm. 🦙
wi.mit.edu/news/harnessing-i…
Tobiloba Oni retweeted
Very interesting study that brings needed attention to unintended immunogenicity of fluorophores and exogenous proteins. However, we should be careful extrapolating these results to other mouse strains and models, particularly C57BL/6. My thoughts: 🧵1/12
Online Now: Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings dlvr.it/SDdfLs
Tobiloba Oni retweeted
November is Pancreatic Cancer Awareness Month! 🎗 One of the best ways to spread the word about this disease is by sharing your story with your friends and family on social media! 📱 Share why you raise awareness and tag us @PanCAN! 💜 pancan.org/awareness #PanCANawareness
Tobiloba Oni retweeted
Whitehead Fellow Tobiloba Oni, @CancerHacker, discusses new frontiers in cancer drug development at GEN Live:
Join us September 20 for GEN LIVE-- @CKadoch and @CancerHacker will discuss where #cancerresearch is now, the challenges it faces and preview the innovative new ways that #cancer is being targeted to develop future therapies. Register today:
ow.ly/P2iH50G8xyG
