postdoctoral researcher in the @SJMorrison_ lab @CRI_UTSW | previously @CSHL @stonybrooku
Dallas, TX
Joined May 2011
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Super thrilled to share my PhD thesis work, now out in @ScienceMagazine, revealing an unexpected redox checkpoint during endosomal progression via oxidative control of the ancestral PI 3-Kinase VPS34
science.org/doi/10.1126/scie…
Tumor metastasis co-opts liver hematopoiesis to promote immunosuppression
science.org/doi/10.1126/scie…
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Perforin triggers iron-induced mitochondrial damage to drive ferroptosis and anti-tumor immunity
cell.com/cell/fulltext/S0092…
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Chronic type II interferon promotes tumor growth through mitochondrial RNA–induced type I interferon and prostaglandin synthesis science.org/doi/10.1126/scie…
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Very interesting paper with a lot of surprises! One of which was the authors having to spend 2 years in revision 😳 after seeing it, I couldn’t unsee it!
Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
nature.com/articles/s41586-0… @Gustavo_SFranca
“this is the legacy of the Warburg effect: a reminder that a simple observation doesn’t have to be understood to be powerful” - so true!
Years of back and forth deep dives vs simplification of the Warburg effect has resulted in several key discoveries!
My favorite part of the Warburg effect? How the gaps in our understanding about why it happens and what it means have fueled the field for a century 🤯
AKA, it's ok if we don't have it all figured out...
Thanks @NatMetabolism for the chance to share! rdcu.be/drFv3
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Why do journal editors wait till every reviewer is done reviewing a paper, to share comments with authors? Can’t they send over a reviewer’s comments to authors as soon as they hear from one? Sure, their final decision can wait till they’ve heard back from all reviewers.
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Reanalyzing data from experiments that I did months ago -
1) data that I thought was “meh” turns out to be quite good 👍😀
2) experiments that I thought was a done deal isn’t as top-notch as I envisioned 🤔🤷♂️
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The problem with generating tons of data is that sooner or later you have to sit down to analyze all of it.
spilled coffee on my mac last week and the keyboard died, only to have it miraculously come back to life today!! :)
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It’s not an off-target effect of my small molecule. It’s a moonlighting function of my favorite inhibitor.
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Dynamic plasticity of prostate cancer intermediate cells during androgen receptor-targeted therapy cell.com/cell-reports/fullte…
It has been 7 years since I was mentored by @Runforhealth65 - she was the main reason I got inspired to study signaling and cancer biology! I may not be in her lab anymore, but she is still my mentor and never misses an opportunity to support her trainees!