@ChrisBakerLab

Twitter feed for the Baker Lab at The Jackson Laboratory in Bar Harbor @jacksonlab

 Bar Harbor, ME
jax.org/research-and-faculty/research-labs/the-baker-lab
Joined September 2021
  • Tweets61
  • Following115
  • Followers202
Very long-awaited, but we're very excited to share Candice Byers’ published work in @embojournal highlighting the impact genetic background has on differentiation bias in mouse embryonic stem cells! 🐁🧬 @jacksonlab @TuftsGSBS tinyurl.com/a6rwp4s9 (a 🧵)
Synopsis of study: We used diverse ESCs and differentiated to EpiLCs and EBs to identify variation in cell state transitions (top). We find that genetically determined chromatin states bias differentiation, with B6 toward neuroectoderm and D2 toward definitive endoderm (middle). Lastly, we used QTL mapping to identify hotspots of trans-regulation of chromatin that impact pluripotency and cell state transitions (bottom).

ALT Synopsis of study: We used diverse ESCs and differentiated to EpiLCs and EBs to identify variation in cell state transitions (top). We find that genetically determined chromatin states bias differentiation, with B6 toward neuroectoderm and D2 toward definitive endoderm (middle). Lastly, we used QTL mapping to identify hotspots of trans-regulation of chromatin that impact pluripotency and cell state transitions (bottom).

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Trainees: apply by January 10th, 2025!
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It was great having you all up to Bar Harbor to learn about the 'diverse' work you're doing! 🧫🧬
Young-Pearse Lab@YoungPearseLab26 Oct 2024
Thank you to @martinperaJAX @ChrisBakerLab @Laura_Reinholdt for inviting Tracy to talk about our lab's work at the recent Diversity in a Dish short course at @jacksonlab! What a great time to talk stem cells and enjoy the Maine Fall colors!
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Had the opportunity to share some recent work at #cshlTE24 🧬 thanks to @CedricFeschotte and organizers for a great experience!
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Registration for #IMGC2025 in Glasgow is open! imgs.org/registration
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🗺️ Explore the potential of pluripotent stem cells at @jacksonlab's workshop, October 21 – 24! Join us for seminars, hands-on method & data analysis workshops, and discussions bridging #Genetics & #StemCell biology: jax.org/education-and-learni… Scholarships available! Learn more ⤵️
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So proud of Mae, our summer student, and all she accomplished this summer! We’re sad to see you go but also excited to see all you do in the future! #JAXSSP #JAXSSP24 @JAX_Education
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✨ NEW DATES ✨ Explore the potential of pluripotent stem cells at @jacksonlab's interdisciplinary workshop, October 21 – 24! Join us for seminars, hands-on method and data analysis workshops, and discussions bridging #Genetics and #StemCell biology: jax.org/education-and-learni…
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Excited to share Lauren's manuscript from their PhD work in @gwcarter's lab at @jacksonlab! doi.org/10.7554/eLife.88222 @eLife

Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.

elifesciences.org
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Help us celebrate the 2024 Early Career Community Award recipients 👏 Six early career scientists are recognized for their outstanding work on their respective research organisms: bit.ly/4bqBdOn Don't miss their presentations at #TAGC24: bit.ly/46zzYcX 🧬
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Is the use of #StemCells an important part of your research strategy? ➡️ Check out this interdisciplinary symposium at @jacksonlab, April 29 – May 2: jax.org/education-and-learni… Organizers: @Laura_Reinholdt, @ChrisBakerLab, @martinperaJAX & Ralda Nehme of @BroadInstitute
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Early registration for #TAGC24 closes tomorrow! IMGS members: Don’t forget to check your emails for a discount code! genetics-gsa.org/tagc-2024/r…

Registration - TAGC24

BRINGING GENETICS TOGETHER

genetics-gsa.org
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Join us at #TAGC24 to hear Gary Churchill give the Beverly Paigen Lecture. #Mammalian24
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#IMGC24 at #TAGC24 will have its own "can't miss" keynote talks: Bev Paigen Lecture - Gary Churchill (Jackson Lab) Verne Chapman Lecture - Beverly Mock (NIH/NCI) Mary Lyon Lecture - Clare Smith (Duke University) Inaugural IMGS President's Award - Jason Bubier (Jackson Lab)
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Yesterday we celebrated @anna_struba's last day before she heads down to @uconnhealth to start graduate school! Wishing you the best of luck in the future and can't wait to see all the cool science you get into! 👩‍🔬
Photo of the Baker Lab outside. Pictured from left to right are: Arad Bustan, Chris Baker, Haley Fortin, Morgan Brady, Anna Struba, and Greg Gadasi.

ALT Photo of the Baker Lab outside. Pictured from left to right are: Arad Bustan, Chris Baker, Haley Fortin, Morgan Brady, Anna Struba, and Greg Gadasi.

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Happy to be a part of this collaborative work headed by Anna Tyler in @gwcarter's group at @jacksonlab along with @TrowbridgeLab, @epgnomike, and others! tinyurl.com/2uvk9jwy 🐭🧬
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Thanks to everyone who helped make this event possible! It was great to learn about how everyone is incorporating genetic diversity into their research! 🧫🧬
JAX Genomic Education
@JAX_Education26 May 2023
Our inaugural @jacksonlab symposium on pluripotent #StemCells in genetic analysis and disease modeling wrapped up today! Thanks to the attendees and speakers for excellent seminars, hands-on methodological and data analysis workshops, and evening discussions. 👏
Picture of symposium participants and faculty standing together on the staircase in the Highseas Conference Center.

ALT Picture of symposium participants and faculty standing together on the staircase in the Highseas Conference Center.

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Excited to share this work on Enhlink, a novel computational approach that leverages single-cell, multiomic data to infer linkages between regulatory elements in collaboration with @jacksonlab colleagues! tinyurl.com/3tkfztv6

Enhlink infers distal and context-specific enhancer-promoter linkages

Enhancers play a crucial role in regulating gene expression and their functional status can be queried with cell type precision using using single-cell (sc)ATAC-seq. To facilitate analysis of such...

biorxiv.org
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Agenda released! ✅ This #StemCell symposium at @jacksonlab will include sessions about genetic impact on pluripotency; modeling human variants in iPSCs; incorporating diverse genetic backgrounds in research; and applications in high-content screening. jax.org/education-and-learni…
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I’m excited to share Diversity in a Dish—a workshop focusing on pluripotent stem cells in genetic analysis and disease modeling at @jacksonlab from May 23-25! We still have spots open if you’re interested/know anyone who may be interested in attending! 🧫tinyurl.com/4hx5pevj
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Stop by P18 to see @haleyjfortin present her work on the trans-regulation of 3D genome contacts at @IMGC2023_sec ! 😊
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