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Pleased to announce the publication in @NatureGenet of our work with Michel Wassef, Raphaël Margueron and others! nature.com/articles/s41588-0… (1/2)
Danny Holoch retweeted
🚨 Job Alert! Please RT 🙏
@ERC_Research-funded postdoc position in our team (up to 3 years) to explore dosage compensation during mouse development 🧬🐭 Join a dynamic, collaborative community @CbiToulouse!
👉 See how to apply here: shorturl.at/De0kj
Danny Holoch retweeted
Happy to share two post-doc papers co-authored with the amazing @AnaMonteagudo4 and @teresa_urli. We had amazing collaborators for both projects, even our supervisor @maxvcg joined in on the experimenting!
1: pubmed.ncbi.nlm.nih.gov/3918…
2: rdcu.be/dXXqh
Danny Holoch retweeted
Usually, I just trash these spam conference invites. But it's not every day I get an email from one of my scientific heroes.
Danny Holoch retweeted
What does the RNA binding surface of PRC2 actually do?
We show that part of the RNA binding surface is required for PRC2 function through interactions with nucleosomes, but we find no evidence that RNA is in play.
nature.com/articles/s41588-0…
Danny Holoch retweeted
Very glad to share our latest publication on TET mode of action !
#drosophila #epigenetics
science.org/doi/10.1126/scia…
Danny Holoch retweeted
Congratulations Danesh Moazed of @harvardmed, newly inducted #NASmember! #NAS161 #genetics #cellbiology
Glad to announce the publication in @NatureComms of our study rdcu.be/dFBcE by Pierre Romero & Laia Richart in Raphaël Margueron’s lab at @institut_curie on the molecular consequences of EZH2 mutations found in non-Hodgkin lymphoma. (1/3)
We combine a powerful isogenic cell culture model with a first-of-its-kind ChIP-seq analysis of follicular lymphoma samples from a unique longitudinal patient cohort to understand the mechanistic impact of EZH2 gain-of-function mutants on chromatin and transcription. (2/3)
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We are immensely grateful for this collaboration with @AVincentSalomon and for funding support from @institut_curie, @Inserm, @CNRS, @FondationARC, @FRM_officiel, @Fondationfrance, @AgenceRecherche and @canceropole. (3/3)
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Danny Holoch retweeted
Happy to share our review dx.doi.org/10.1002/wrna.1848
we highlight the similarities and differences between ciliates and other eukaryotes in small-RNA-directed chromatin silencing.
@IJMonod @CNRSbiologie @toma_bln @DannyHoloch
Danny Holoch retweeted
🚨New Preprint🚨 In this study, we set out to determine how the de novo DNA methylation program impacts the 3D cis regulatory landscape. Comments welcome! Here's a thread detailing our study's key findings (1/12) biorxiv.org/content/10.1101/…
Danny Holoch retweeted
Preprint alert. We’re thrilled to announce the latest work from our lab: The nuclear PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium. A thread with our key findings: (1/6) biorxiv.org/content/10.1101/…
Danny Holoch retweeted
DNA methylation can antagonize Polycomb-mediated gene silencing - neat!
biorxiv.org/content/10.1101/…
Danny Holoch retweeted
🚨Preprint Alert🚨 I am very proud to present our latest work, describing how DNA methylation shapes the polycomb landscape. A team effort, led by @jrichardalbert, @teresa_urli, and @AnaMonteagudo4 in the lab. Here's a 🧵 highlighting 🗝️ findings (1/12) biorxiv.org/content/10.1101/…
Danny Holoch retweeted
Very glad to share our preprint: Non-catalytic function of PRC2 in the control of small RNA dynamics during programmed genome elimination in Paramecium biorxiv.org/content/10.1101/…. Feedback and comments are welcome !
Danny Holoch retweeted
Very honored to be part of the @EMBO community. Thanks to past and present lab members, and collaborators, and to @IJMonod for a great environment.
EMBO announces the election of 69 new members and associate members who join the EMBO community of more than 2,000 leading life scientists in Europe and beyond
embo.org/press-releases/embo…
Danny Holoch retweeted
🚨Review Drop🚨 @jrichardalbert & I explored the cutting edge of non-canonical imprinting. We also added our thoughts on the developmental and evolutionary importance of the phenomenon. A great exercise to think deeply about mammalian epigenetics (1/5) journals.biologists.com/dev/…
Danny Holoch retweeted
So cool to see Sandra @DuharcourtLab honored tonight with the prestigious @CNRS silver medal! Such a well-deserved recognition for a brilliant scientist and an even better colleague!!
Danny Holoch retweeted
Transcriptional Memory ✅
Chromatin Modifications ✅
Transmission across meiosis ✅
Did Susan Strome et al satisfy everyone's definition?? Plus she defined the E-word in the first paragraph 🥹. As usual, very elegant work to boot (no pun intended). pnas.org/doi/abs/10.1073/pna…
Danny Holoch retweeted
🥳Congratulations to @MathildeJDura @DeborahBourchis and all authors for their work out now in @NatureGenet, where they describe the function of DNA methylation in male fertility 🧬🐭
👉🏽tinyurl.com/bdfrybex
@institut_curie @AgenceRecherche @FRM_officiel @Fondation_BS
