@DrewCarson712

PhD Candidate in Link Lab at Princeton; Motivated by bacterial natural products and their biosynthesis and bioactivities.

Joined October 2021
  • Tweets76
  • Following248
  • Followers102
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Drew Carson retweeted
A. James Link@ajlinklab8 Jan 2025
The latest Link lab paper is out @BiochemistryACS!: doi.org/10.1021/acs.biochem.… This work, led by Angela Zhu, focuses on the cysimiditides, a new subfamily of #RiPPs. The cysimiditides include a tetracysteine motif that coordinates a zinc ion and a single aspartimide moiety.

Cysimiditides: RiPPs with a Zn-Tetracysteine Motif and Aspartimidylation

Abstract. Aspartimidylation is a post-translational modification found in multiple families of ribosomally synthesized and post-translationally modified pe

pubs.acs.org
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Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
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Emergence of a distinct mechanism of C–N bond formation in #photoenzymes by Felix C. Raps @felix_raps, Ariadna Rivas-Souchet, Chey M. Jones @CheyMJones, and Todd K. Hyster @HysterLab at @PrincetonChem nature.com/articles/s41586-0…
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Excited to be at @BostonBacteria at Boston Univ! Looking forward to some great science #BBM2024 🧫 I’m presenting poster number 104 tomorrow, come say hi!
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Drew Carson retweeted
Howard Salis@hsalis22 May 2024
Psst. Hey. Yeah you. Want to build 100s to 1000s of plasmids (*any sequence* up to ~6000 bp) for about $10 to $40 each? salislab.net/software/build_… Try it out ... feedback is welcomed & encouraged :)
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Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize several sidechain- and backbone-modified precursor peptides and demonstrated their in vitro transformation. pubs.acs.org/doi/10.1021/jac… @UZH_Chemistry @Hartrampf_Lab

Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides

Abstract. Many peptidic natural products, such as lasso peptides, cyclic peptides, and cyclotides, are conformationally constrained and show biological sta

pubs.acs.org
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Our chemical synthesis of PTM-modified MYC peptides and their interactions with the tumor suppressor Bin1 is online @ChemicalScience. Congratulations @elysetwilliams, @rebeccabev5, @ZerbeOliver, and everyone else involved! 🎉 pubs.rsc.org/en/content/arti… #MyFirstChemSci
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Excited to release our latest work, led by Sebastian Gonzalez La Corte (@sesgonzalez) with Ned Wingreen: doi.org/10.1101/2024.04.18.5…! Here, we show that polymers unexpectedly sculpt proliferating bacterial colonies into spaghetti-like "cables".🦠🍝 Tweetorial follows! [1/10]
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The latest Link lab paper is out @J_A_C_S today led by @bsmchoi: pubs.acs.org/doi/10.1021/jac…. In this work we show that ATP grasp enzymes that usually make esters can also make thioesters.

Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation

Abstract. The ribosomally synthesized and post-translationally modified peptide (RiPP) superfamily of natural products includes many examples of cyclic pep

pubs.acs.org
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Drew Carson retweeted
ChemBioChem@ChemBioChem2 Apr 2024
Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria (C. Melander et al.) @MelanderLab onlinelibrary.wiley.com/doi/…

Identification of a 2‐Aminobenzimidazole Scaffold that Potentiates Gram‐Positive Selective Antibi...

Small molecule adjuvants have the potential to expand the spectrum of gram-positive selective antibiotics to encompass gram-negative bacteria. We identifiy a series of 2-aminobenzimidazole (2-ABI)...

chemistry-europe.onlinelibrary.wiley.com
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Excited to share the latest Link lab paper on the uptake of lasso peptide antibiotic cloacaenodin into susceptible bacteria. The work was led by @DrewCarson712 in the Link lab and another collab with @ZhongyueY. pubs.acs.org/doi/full/10.102…

Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access...

Abstract. The development of new antimicrobial agents effective against Gram-negative bacteria remains a major challenge in drug discovery. The lasso pepti

pubs.acs.org
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Our new paper is just out now in ACS Chemical Biology! Here we uncover the transport pathway that the antimicrobial lasso peptide cloacaenodin uses to be able to kill susceptible bacteria. This helps explain the narrow-spectrum activity we observe. pubs.acs.org/doi/10.1021/acs…

Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access...

Abstract. The development of new antimicrobial agents effective against Gram-negative bacteria remains a major challenge in drug discovery. The lasso pepti

pubs.acs.org
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Our lab's work highly suggests that narrow-spectrum antimicrobial lasso peptides (MccJ25, cloacaenodin, ubonodin) evolved their specificities as a result of their hijacking unique, outer membrane proteins (using active transport) to cross the formidable Gram-neg outer membrane.
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Very happy to have this out! Huge thanks to everyone involved in this. A fun collaboration with the Yang lab at Vanderbilt. @ajlinklab @ZhongyueY @EPrinceton @VanderbiltChem @ACSBioMed
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Our preprint on “Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides” is now available from @ChemRxiv 🧪🧫. Congratulations to first author Kevin Schiefelbein and everyone else involved 🥳 chemrxiv.org/engage/chemrxiv… @Hartrampf_Lab
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Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by @MarianaNoto published @ScienceMagazine addresses this fundamental question (1/n) science.org/doi/10.1126/scie…
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Drew Carson retweeted
Tom Ellis@ProfTomEllis25 Jan 2024
Another exciting new tool to engineer biology from the Jason Chin Lab >>> Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli | Science science.org/doi/10.1126/scie…

Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli

An Escherichia coli orthogonal replication system (EcORep) allows massively accelerated continuous evolution of introduced DNA in bacterial cells.

science.org
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