Exploring Omics in the Light of Evolution PI: @iAmphioxus
Guangzhou, Guangdong, China
Joined October 2020
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Very happy to share a recent preprint from our lab on multidimensional telomere characterization, which combines state-of-art software development and cross-species analysis on #telomere diversity regarding length, variant repeat, and DNA methylation.
biorxiv.org/content/10.64898…
Happy to share our recent preprint on experimental evolution for bleomycin resistance in yeast, in which we highlight both background-dependent mutational footprints and a shared molecular mechanism underlying their adaptation.
biorxiv.org/content/10.64898…
#yeast #LTEE
Glad to see this joint work on nasopharyngeal microbiota culturomics officially published in @ScienceTM, featured as a cover story! By building this local bacterial catalog, we characterized a Fusobacterium-Prevotella mutualism in nasopharyngeal tumors.
science.org/doi/10.1126/scit…
Glad to see this joint work finally out in @NatureCancer! A truly tour-de-force multiomics quest into nasopharyngeal carcinoma subtyping and its clinical implications! nature.com/articles/s43018-0…
7/n: This work would not be possible without the long-term support of our collaborators, namely Linda Z. Holland, Jr-Kai (Sky) Yu @JKSkyYu , & Sung-Jin Cho. Many thanks to everyone involved!
6/n: Taken together, our findings illuminate the genome and gene evolution of amphixous and the cephalochordate subphylum that they represent, as well as provide valuable resources for understanding the early evolution of chordates and the origin of vertebrates.
5/n: We also elucidated the evolutionary history of some important genes/locus underlying development & immune functions (e.g., Hox, TLRs, NLRs, MHC, RAGs) during chordate evolution.
4/n: The strong micro-synteny conservation is at least partially explained by co-transcriptional regulatory constraints, with those genes enclosed in the same micro-syteny block showing higher correlation of both gene expression profiles and molecular evolution.
3/n: We found Asymmetron has a larger genome, driven mainly by intergenic TE expansion. Despite such TE expansion, the Asymmetron genome show substantial macro- and micro-synteny conservation with other amphioxus species and even vertebrates.
2/n: In this work, we assembled a chromosome-level genome for Asymmetron lucayanum—the earliest diverging cephalochordate genus—expanding beyond the current Branchiostoma-centric view regarding cephalochordate genome evolution.
Excited to share our PNAS paper on the genome evolution of an early-diverging #amphioxus, Asymmetron lucayanum! There is a long and twisty story behind this work, which also explains the username choice of the lab PI @iAmphioxus .😀 @PNASNews
pnas.org/doi/10.1073/pnas.25…
EvomicsLab retweeted
Honored to serve on the Yeast Genetics Meeting Program Committee of Evolution & Population Genetics. Welcome for meeting registration and abstract submission, especially on our Evolution & Population Genetics program! genetics-gsa.org/yeast-2026/ @geneticsGSA #Yeast26
First #SMBE meeting for our lab！Definitely a memorable experience. Already looking forward to the next one! @OfficialSMBE #SMBE2025
📢Glad to share our genome paper on an early-diverged cephalochordate species, Asymmetron lucayanum! By decoding & analyzing this genome in a comparative genomics framework, we know better now regarding the genome and gene evolution in cephalochordates.
biorxiv.org/content/10.1101/…
EvomicsLab retweeted
📢Our #SMBE 2025 Symposium (No. 3) on Experimental Evolution will be held today (7.22, Tuesday) at 10:30 in Room 4, Building No. 8. An associated poster session will be held at 14:00 (poster number: S3-P01~P16). Welcome to join! let's study evolution in action! 🥳 @OfficialSMBE
EvomicsLab retweeted
Welcome to attend our Symposium on Experimental Evolution. Co-organized by Dao-Qiong Zheng, @iYeast_jingli and myself.
#SMBE2025 Symposium 3: Experimental evolution: studying evolution in action
🔗 smbe2025.scimeeting.cn/en/we…
Glad to see the copy-edited version of our VRPG paper formally published in the latest issue of @genomeresearch ! We developed VRPG as a novel visualization framework for intuitively exploring pangenome graphs in a linear-reference-projected context.
genome.cshlp.org/content/35/…
EvomicsLab retweeted
📢📢📢 The FINAL COUNT DOWN for the extended abstract submission deadline of #SMBE2025! Please submit your abstract by 23:59 (GMT +8) of February 15, 2025 [Saturday]! And shout out again for our Experimental Evolution symposium! 🎉🎉🎉 @OfficialSMBE #LTEE #ExperimentalEvolution
📢📢📢 #SMBE2025 Abstract Submission EXTENDED to Saturday, February 15, 2025
We also invite you to register at smbe2025.org/
@SMBEmeetings
EvomicsLab retweeted
*** Notification: New class in Evolutionary Cell Biology open to the public during Spring 2025 semester
The class is taught by Dr. Michael Lynch every Tuesday and Thursday, 9:00-10:15 am (MST), starting on 16 January 2025
Join: asu.zoom.us/j/86824596554
Dtls: [email protected]
Many thanks to @Time_long_river for leading the development of VRPG. Built upon VRPG, we are currently working on new development and discoveries with #pangenome graphs. Stay tuned!