@FesenkoIgor

Peptidomics; Proteomics; Microproteins; tweeting as an individual

 Cambridge, MA
igorfesenko.github.io
Joined November 2017
  • Tweets1.1K
  • Following463
  • Followers278
132Media
(1/2) How did RNA and peptides organize before specific protein sequences existed? Our new study shows that heterogeneous peptide populations can spontaneously form liquid-like RNA-rich condensates with a model of the ancient ribosome.
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Happy to announce that our paper on orphan genes in bacteria dropped in PNAS yesterday! This is a problem I've been thinking about since the start of my PhD. Grateful for this journey, as well as All The Friends I Made Along the Way. Also, Eid Mubarak to those who celebrate!
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New online! Emergence and evolution of protein-coding de novo genes dlvr.it/TQcswP
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Igor Fesenko retweeted
Anne Lopes@anne__lopesJan 12
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: nature.com/articles/s41467-0… Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
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I am happy to present our new paper on the de novo birth of microproteins in bacterial intergenic regions, conducted in collaboration with #storzlab. academic.oup.com/nar/article…

De novo origin of numerous microproteins in enterobacteria

Abstract. Bacterial genomes encompass numerous small open reading frames (smORFs), some of which encode functional microproteins or perform noncoding regul

academic.oup.com
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Latest from the lab: we’ve found that arbitrium phages can cross-communicate across species. Their molecular “language” isn’t as private as we thought. The original idea came from @AlbertoMarina14. As always, he was right. biorxiv.org/content/10.1101/…

Phages communicate across species to shape microbial ecosystems

Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX...

biorxiv.org
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Igor Fesenko retweeted
Bruno Ngou@BrunoNgou4 Sep 2025
Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @ScienceMagazine! science.org/doi/10.1126/scie…

Systematic discovery and engineering of synthetic immune receptors in plants

Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase...

science.org
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New Letter: "Large-scale pairing identifies a soybean phytocytokine-receptor module conferring disease resistance" rdcu.be/eBmrZ Scalable pipeline for systematic peptide–receptor discovery. In soybean, identification of a PEP914/890-P98R module in disease resistance.
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Igor Fesenko retweeted
Cell@CellCellPress21 Aug 2025
Now online! A receptor antagonist counterbalances multiple systemin phytocytokines in tomato dlvr.it/TMcdxq

A receptor antagonist counterbalances multiple systemin phytocytokines in tomato

Tomato antiSYS is a natural receptor antagonist that counterbalances agonistic systemin phytocytokines. Its deficiency triggers autoinflammatory-like symptoms affecting growth and development of...

cell.com
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🧬 How have tiny immune-signaling peptides evolved across the plant kingdom? Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants bit.ly/4eAUnmZ
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Happy to share our latest publication, just out @PlantCellRep: Recombinant production of spider silk protein in Physcomitrella photobioreactors @CIBSS_UniFR @livMatS_UniFR rdcu.be/eju1k
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Online Now: Modulation of protein activity by small RNA base pairing internal to coding sequences dlvr.it/TK2fCX
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The hidden bacterial microproteome dlvr.it/TJNplq
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Happy to share our new publication, just out in @CommsBio: Comparative analysis using a chromosome-scale genome assembly for Funaria hygrometrica suggests greater collinearity in mosses than in seed plants. Finally, the #Funaria genome at chromosome scale! nature.com/articles/s42003-0…

Comparative analysis using a chromosome-scale genome assembly for Funaria hygrometrica suggests...

Communications Biology - A study suggests that moss genomes tick differently than seed-plant genomes, experiencing fewer rearrangements and thus being more collinear. This may explain their smaller...

nature.com
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Igor Fesenko retweeted
Feng Zhang
@zhangf27 Feb 2025
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…

TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses

RNA-guided systems provide remarkable versatility, enabling diverse biological functions. Through iterative structural and sequence homology-based mining starting with a guide RNA-interaction domain...

science.org
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Online Now: The hidden bacterial microproteome dlvr.it/TJ4HL2
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We’ve wrapped up another fantastic meeting, celebrating the achievements of our award winners & the successful conclusion of our Microproteins conference! Congrats to Carly Houghton, @JuveriyaQamar , & Achala SF Vitharanage. @tfmPhD @carvunis #keystonesymposia #keystoneawards
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Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now @PNASNews: pnas.org/doi/10.1073/pnas.23…. @MITBiology @ScienceMIT @HHMINews See quoted thread on the updated preprint for details:

High-throughput discovery of inhibitory protein fragments with AlphaFold | PNAS

Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger prot...

pnas.org
Andrew Savinov@bioSavinov27 Sep 2024
Excited to share our updated manuscript on FragFold, the massively parallel AlphaFold-based approach we’ve developed to discover protein fragment inhibitors at scale -- w/ @SassSeabass, @keating_lab, and @GeneWeiLiLab. biorxiv.org/content/10.1101/… (1/n)

High-throughput discovery of inhibitory protein fragments with AlphaFold

Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these...

biorxiv.org
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TiG's February issue is devoted to microproteins and the small ORFs that encode them. Check it out! cell.com/trends/genetics/iss…
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Happy to share our latest publication: Differential GTP-dependent in-vitro polymerization of recombinant #Physcomitrella FtsZ proteins @livMatS_UniFR @CIBSS_UniFR @BUnifr nature.com/articles/s41598-0…

Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins

Scientific Reports - Differential GTP-dependent in-vitro polymerization of recombinant Physcomitrella FtsZ proteins

nature.com
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