@FilianoLab

We study neuroinflammation, autoimmunity, and rare diseases.

 PSU ➡️ UAB ➡️ UVA ➡️ Duke
FilianoLab.org
Joined April 2017
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A special issue curated by guest editor @FilianoLab at @Dukeneurosurg highlights nine reviews discussing the multi-directional communication that occurs between the central nervous system, the surrounding tissues, and the immune system. Read it now: ow.ly/GTNh50YNzTC
Illustration of a human head with a brain surrounded by a castle wall, symbolizing immune defenses at brain borders, with microscopic immune cell images.

ALT Illustration of a human head with a brain surrounded by a castle wall, symbolizing immune defenses at brain borders, with microscopic immune cell images.

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Was a blast guest editing this special issue for @J_Immunol . Check out these amazing reviews on brain border sites. academic.oup.com/jimmunol/ar…

Neuroimmune communication at the borders of the brain

The concept of a central nervous system (CNS) border originates from the late 19th century work of Paul Ehrlich and Edwin Goldman showing that water-solubl

academic.oup.com
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Filiano Lab retweeted
Danny Saban
@SabanLab5 Aug 2025
Check out our new preprint on a novel neuro-immune niche that underpins touch sensation.
bioRxiv Immunology@biorxiv_immuno1 Aug 2025
The Cornea Harbors a Tricellular Neuro-Immune Niche that Underpins Touch Sensation biorxiv.org/content/10.1101/… #biorxiv_immuno

The Cornea Harbors a Tricellular Neuro-Immune Niche that Underpins Touch Sensation

Piezo2 is a mechanosensitive ion channel essential for touch and proprioception, yet the mechanisms that maintain this sensory modality in adult tissues are unknown. Using multiphoton imaging of the...

biorxiv.org
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Replying to @jonykipnis @ImmunologyAAI @LukensJohnR
Covering all the landmark papers!
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Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions corporate.dukehealth.org//ne…

Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions

DURHAM, N.C. – Building on research that has linked immune responses with certain neurobehavioral conditions, researchers at Duke Health have identified how a key infection-fighting function is...

corporate.dukehealth.org
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Replying to @Dukeneurosurg
Thanks Sarah Avery and Carol Harbers for this great coverage of @immunodani’s study
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New study from @FilianoLab links immune system to neurobehavioral conditions: "This work may have implications for ADHD, autism, and schizophrenia and open doors for investigating other conditions like Parkinson’s and substance abuse disorder." neurosurgery.duke.edu/news/s…
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Replying to @jonykipnis
Nice! Can’t wait to curl up in front of the fire with this one.
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Replying to @jonykipnis
Ha, ya. Also looks like an Otter cracking a hippocampal clam
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Today I was discussing the evolutionary differences in the mouse and human brains. Please feel free to use this in your lectures. Really, you don’t even need to give me credit.
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@ImmunologyDuke @Dukeneurosurg
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This was the final chapter to Dr. Clark’s thesis and can’t wait to see how much see accomplishes in her career.
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Excited to share our labs latest work looking at how Prolonged STAT1 signaling in neurons causes hyperactive behavior. We think this could have implications for ADHD and other neurological conditions affecting the basal ganglia. @immunodani sciencedirect.com/science/ar…
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Did you know that the fetal immune system can protect from congenital infection before birth? -Proud to share our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection.
Cell@CellCellPress12 Nov 2024
Now online! Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection dlvr.it/TG7FfY
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Thrilled to share new work from our lab led by ⁦@mitchkim_mw⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s41586-0…

Endogenous self-peptides guard immune privilege of the central nervous system

Nature - Central nervous system (CNS)-derived regulatory self-peptides are essential for maintaining a continuous dialogue between the CNS and the immune system while balancing overt autoreactivity.

nature.com
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Hyunjung Min et al. @FilianoLab reveal a mechanism by which mural cell–#macrophage interactions regulate the trafficking of CNS antigen-specific T cells to the dura. hubs.la/Q02Tfxbb0 📘 In our #Autoimmunity collection: hubs.la/Q02TfwNt0
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Hyunjung Min et al. @FilianoLab reveal a mechanism by which mural cell–#macrophage interactions regulate the trafficking of CNS antigen-specific T cells to the dura. hubs.la/Q02RDb4D0 📘 In our #Neuroscience collection hubs.la/Q02RD9SC0 #SfN24
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Filiano Lab retweeted
John Lukens@LukensJohnR6 Sep 2024
🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! @uvavpr @BIG_Center_UVA @UVANeurology
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Replying to @jonykipnis @Drieu_Antoine @kipnislab
Congrats Kipnis lab! Loved hearing about this on your visit. Can’t wait to read.
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Replying to @ImmunityCP @dasNeves_SP
Congrats Sandro! Nice work.
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