Cork man🔴⚪️in Dublin🇮🇪, Asst Prof TCD, examining macrophages&TB🦠🧫🔬, gay🏳️🌈, he/him,Tweets about science🧬,buffy🧛🏽♀️,sci-fi🚀,celebs📸 all mine😂👍🏻
Dublin City, Ireland
Joined June 2011
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Retweeting my “ ‘Stand-Up’ for Vaccine Equity” from last week youtu.be/eGqQWb-XcEQ – at Dublin City, Ireland
While I’ve been on vacation the work of my amazing PhD graduate @LedwithAnna in collaboration with @HelenMRoche & many others has been published @CellReports - thanks to @Researchirel for support showing yeast beta-glucans can support obesity-induced immune dysregulation
Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis dlvr.it/TTRtDK
FreddieMac(rophage) retweeted
Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis dlvr.it/TTRtDK
Can’t wait for my first trip to Manchester - sign up today for a great day of Immunology & Representation!!
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Well done @chjohnston11 - a lot of hard work & enthusiasm on display
Always a pleasure to get to show off your hard work and chat science at conferences. Beautiful location in Berlin organized by @DRFZ_Berlin. Fascinating conference all about the development of memory in the immune system 👨🏻🔬🧬
One week left to get applications in for joining our team - any immunologists/metabolism pps @Irishimmunology
We're hiring.... joint project 'Diet, Metabolism and Innate Immune Training' with @Fredtwee Great team to join!! @UCD_Conway @tcdTBSI
Come join our Metabo-Train 🚂🚂🚂
We're hiring.... joint project 'Diet, Metabolism and Innate Immune Training' with @Fredtwee Great team to join!! @UCD_Conway @tcdTBSI
This work wouldn’t be complete without support from our Industry Partner @WeAreKerry @wellmune Team inc Sonja, Laura et al, #EnterpriseIreland who funded it via an Innovation Partnership scheme & the work of many students through the lab over the years (10 ex 12)
Importantly, it would not be complete & published without 3 stars who worked really hard on revisions, all while juggling other commitments, our 3 joint 1st Authors @chjohnston11 @LedwithAnna @MleLundahl - thank you all (11 ex 12)
And shout-out to former lab member @sioshaug who started the work as an undergrad & gave the project wheels. We hope anyone interested in #TrainedImmunity finds this useful and gains some tools to further study the role of this process in infection & disease - (12 ex 12)
We started this work ~7 years ago in an effort to improve responses to hard to treat infections like #TB #EndTB & set-up a collaboration with Irish Food Company @kerrysites (3/12)
We & other groups are now working on whether this represents true long-term innate immune memory and can lead to improved responses to challenge, so #WatchThisSpace @LedwithAnna (9ex12)
2nd) Different ways of delivering WGP b-glucans orally – including via dietary supplementation - led to the same features of Trained Immunity in mice, chiefly increased myelopoiesis in the bone marrow reservoir of immune cells. (8ex12)
Our work & a recently published paper (nature.com/articles/s41598-0…) shows other pure yeast b-glucan particles can Train & taken together, this increases the tools available to study #TrainedImmunity which hopefully will inform other groups trying to work with these tricky molecules(7
while in the works, a number of other groups demonstrated Training with WGP, but WE show here that 1) the method of preparation & Purity is key so the B-glucan particle can engage the Dectin-1 receptor in the right way to bring about the intracellular reprogramming for Training(6
We set out to establish 1) if this b-glucan could Train our innate immune system in the same way as seen for b-glucans derived from Candida & 2) could oral delivery Train the innate immune system. Long story short- it did and it does, which is important for a number of reasons;
@WeAreKerry who had recently acquired a common bakers yeast-derived Whole Glucan Particle –we call WGP– aka @wellmune,which was known to activate the innate fungal receptor Dectin1 –as well as being a well-tolerated food ingredient like @PharmaPlusAssoc #ActiveImmune range (4/12)
Finally out there - Recognition of yeast β-glucan particles triggers immunometabolic signa... sciencedirect.com/science/ar… Tweetorial Follows (1/12)
I'm over the moon to see this labour of love finally online @iScience_CP –our labs 1st foray into b-glucan induced Trained Immunity to support the responsiveness of our favorite patrolling cells – the Macrophage, aka Big Eater (2/12)
FreddieMac(rophage) retweeted
📢HIRING.
💥3 Postdocs. 💥1 Technical Staff
International collaborative project on #Mitochondria #Membrane contacts & #liver disease!
For more information or to APPLY, DM me or click this link: tr.ee/KGMze4zKEq
#Share #Retweet #Mitochondria #MASLD #NAFLD #Postdoc
Register for this great meeting open now (link below) - where I will expand on our just accepted work @iScience_CP, which explores how we can boost innate immune function, particularly in the context of dysregulated metabolism cell.com/iscience/fulltext/S… @BSI_immunomet
