@LedwithAnna

Immunology PostDoc at Trinity College Dublin/UCD | interested in obesity and cancer immunology

Joined January 2020
  • Tweets29
  • Following333
  • Followers128
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Anna Ledwith retweeted
FreddieMac(rophage)@FredtweeJul 16
While I’ve been on vacation the work of my amazing PhD graduate @LedwithAnna in collaboration with @HelenMRoche & many others has been published @CellReports - thanks to @Researchirel for support showing yeast beta-glucans can support obesity-induced immune dysregulation
Cell Reports@CellReportsJul 10
Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity-induced dysfunction via trained hematopoiesis dlvr.it/TTRtDK

Yeast β-glucan supplementation supports immunometabolic anti-tumor responses and reverses obesity...

Ledwith et al. demonstrates that dietary yeast β-glucan induces trained immunity by reprogramming myeloid hematopoietic progenitors, generating metabolically enhanced monocytes and macrophages with...

cell.com
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Anna Ledwith retweeted
Basdeo Lab@BasdeoLab30 May 2025
New paper alert! 🥳We are so proud to share this amazing work from the lab led by @SarahA_Connolly and @aaronbreathnach. In this study, we show that the BTN162b2 mRNA vaccine induces anti-inflammatory trained immunity in humans 💉💉Read more here: sciencedirect.com/science/ar…
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Pleased to share our latest paper in @ScienceAdvances on myeloid cell ‘trained hypercoagulability’! 🚀 Project led by @AislingRehill - huge thanks to our collaborators & funders @IrishCtrVascBio @RCSI_Irl @tcddublin @Researchirel @hrbireland @CHIatCrumlin! tinyurl.com/df4fsrrx
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Deep in scientific mode vs relaxing after a wonderful conference @iSTIIIMDD in Dresden. Wonderful opportunity to present some of the data I've been working on in #TrainedImmunity. Massive congratulations to @LedwithAnna for a fantastic presentation and winning a travel award 🎖️
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If you're interested in how dietary supplements can protect against viral infections I will be presenting some of my PhD data at #ECI2024! 🦠🔬 Talk at 5pm in the Viral Immunity section on Tuesday the 3rd of September
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Kicking off ECI action with the @Fredtwee Lab @pintofscienceIE – at Dublin City, Ireland
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My very first-author work as just been published in Americal Journal or Reproductive Immunology! This work has started during the 2020 lockdown and made me realise how much database investigation can help gaining insights about evolution of immune genes! onlinelibrary.wiley.com/doi/…

Evolutionary Analysis of the Mammalian IL‐17 Cytokine Family Suggests Conserved Roles in Female...

Problem The interleukin-17 (IL-17) family includes pro-inflammatory cytokines IL-17A-F with important roles in mucosal defence, barrier integrity and tissue regeneration. IL-17A can be dysregulated...

onlinelibrary.wiley.com
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Excited to share our new publication in @EurJImmunol. We have shown that IL-17A-producing Vγ4 γδ T cells are regulated by PD-1 in the EAE model. Thanks to @MillsKingston for the support and supervision as well as Caroline Sutton and Barry Moran @tcdflow onlinelibrary.wiley.com/doi/…

PD‐1 regulation of pathogenic IL‐17‐secreting γδ T cells in experimental autoimmune encephalomyel...

PD-1 signaling suppresses IL-17A production by TCR-activated CD27− Vγ4 γδ T cells. Anti-PD-1 treatment exacerbates experimental autoimmune encephalomyelitis by enhancing IL-17A production by CD27−...

onlinelibrary.wiley.com
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Introducing the STEM book club! 📚🧬 Our goal is to foster enriching conversations and a deeper appreciation for the scientific wonders that shape our world. Join us for our first event in the Hole in the Wall, 5th of August, where we will be discussing Humanology ✨📚 – at Galway, Ireland
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Delighted to see the work finally published! Mammoth effort from @chjohnston11 - excited for more to come!
FreddieMac(rophage)@Fredtwee12 Feb 2024
Finally out there - Recognition of yeast β-glucan particles triggers immunometabolic signa... sciencedirect.com/science/ar… Tweetorial Follows (1/12)
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Finally out there - Recognition of yeast β-glucan particles triggers immunometabolic signa... sciencedirect.com/science/ar… Tweetorial Follows (1/12)
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Joining us for the 3rd biennial Sex Differences conference? There are just over 30 days to submit your abstract! Register now at sex-differences-immunology.c… to be in with a chance of securing a travel grant for junior scientists - generously supported by @EFIS_Immunology & EJI.
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Very proud of @chjohnston11 presenting his PhD work on b-glucan induced anti-viral trained immunity at @bsicongress !🦠🍄 #bsi23
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The FJS Lab enjoying the calm before the storm @bsicongress
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Professor Cliona O'Farrelly has today been named a 2022 @aaas Fellow. Cliona has been honoured for her outstanding achievements as a researcher in the field of comparative immunology. Read more at: bit.ly/3jjlGdb
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Anna Ledwith retweeted
Ross Ward@RossWWard4420 Jan 2023
Please check out our new paper just published in @CellRepMed - We show that for polymeric particulate adjuvants size matters! cell.com/cell-reports-medici… We demonstate the size dependant adjuvanticity of polymeric particulate adjuvants and uncover the underlying mechanisms ⚙️ (1/4)

Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

Muñoz-Wolf et al. show that particle size dictates the induction of cell-mediated immunity by polymeric nanoparticulate adjuvants, identifying 50–60 nm as the optimal size for induction of Th1/CD8+...

cell.com
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Our paper on in situ barcoding using a synthetic VDJ recombination (Diversity through RAG) approach is out now on biorxiv. More details in Leila's thread below!
This Post is from an account that no longer exists. Learn more
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It’s published🎉! It will be hard for me to focus on my cardiology final today with my brain thinking about this🙃 If you want to learn more about trained immunity & pregnancy complications, here is the link: doi.org/10.3390/cells1123393… @MDPIOpenAccess @CharlesHGraham @SGPlacenta – at Montréal, Québec
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Anna Ledwith retweeted
Jamie@MrJamieSugrue6 Nov 2022
Our paper on innate resistance to hepatitis C virus infection is out in @CellRepMed this weekend! cell.com/cell-reports-medici… 1/12

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort

Natural resistance to infection is an often-overlooked outcome after exposure to HCV. Here, Sugrue et al. describe HCV resistance in a cohort of women accidentally exposed to HCV in the 1970s and...

cell.com
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Anna Ledwith retweeted
Sanjee Baksh@S__Baksh22 Oct 2022
T-cells on their way to a tumor vs when they’re in a tumor
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