After watching the demo videos, had to dig this old post up...
#jokingbutnot
xitter.cf/GavinRayDev/status/205…
Gavin Ray retweeted
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude.
At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells.
Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI.
We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force.
Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
Gavin Ray retweeted
I built bbtree, the foundation of databases and filesystems, and the fastest concurrent btree.
Code: github.com/XiangpengHao/bbtr…
Blog post & demo: bbtree.xiangpeng.systems/
I just experienced something novel with LLM's I've never seen before:
For a single word, Gemini Argon 4 invented a term by combining a different language root with an English suffix:
> "банаl", from common Slavic "бана"-root with a Latin "l" suffix, for "banal"
Gavin Ray retweeted
Today we’re launching something for the era where every AI logo looks like a butthole,
❌ Bots
❌ Dots
✅ Pots
Supports all models. Except Muse, obv.
Gavin Ray retweeted
What if,
for any scientific claim,
you can search 100M+ papers to find the strongest evidence for and against it
⚡️in 1 second?
That’s now possible with Evidence API! 🚀
paperclip.gxl.ai/evidence-ap…
For example, does drinking coffee reduce diabetes risk?
Excuse me:
> "we screened millions of pathway combinations to engineer essential amino acid biosynthesis, achieving near-wild-type growth without valine and enabling isoleucine-free growth"
They took the "essential" out of "essential amino acid" 🤯
Highly multiplexed mammalian metabolic engineering with a shotgun approach - @sudpinglay @JefBoeke nature.com/articles/s41587-0…
Gavin Ray retweeted
As shown in our recent study, good gains in muscle strength and size can be achieved with as little as ~1 hour of resistance training per week, provided sets are performed with a high level of effort (close to failure). For most of the general population, this can be sufficient to achieve their strength and muscle-building goals. The key is simply to get to the gym, train hard and be consistent 💪
pubmed.ncbi.nlm.nih.gov/4024…
Gavin Ray retweeted
Imagine effortlessly gaining deeper insights into your nighttime recovery 💤
A new feature, arriving this fall on Pixel Watch, will track your sleep breathing quality, helping you understand how your body rests. No wires, no sleep study needed.
goo.gle/4q8zDbM
TIL: You can append ".diff" to a Github PR URL to download the changes as a diff file 🤯
Super useful for copy-pasting as LLM context when the PR is not in the conversation history
Smol blogpost on why I think Design-by-Contract and Effects/Capabilities systems are more valuable with LLM-generated code
gavinray97.github.io/blog/de…
Gavin Ray retweeted
Photos & video were how the last generation expressed themselves.
Today’s form of expression is software.
Who will create the next viral game or app that plays right inside of the X Timeline?
Try the new Grok app builder.
Gavin Ray retweeted
Yep. To that point, my dissertation research investigated a bodybuilding style workout (3 x 10) vs a powerlifting style workout (7 x 3). By the end of the 8-week intervention, the powerlifting group was pretty spent and had nagging injuries while the BB group was well-recovered.
The vast majority of studies use a moderate rep range so it's basically a default when discussing the topic
pubmed.ncbi.nlm.nih.gov/2471…
Really neat new study:
> "Large increases in resistance training volume do not impair muscle hypertrophy or anabolic-catabolic molecular signaling in trained individuals (2026)"
journals.physiology.org/doi/…
If you know me, have a ProductHunt account, and want to do me a solid, my org launched on PH today and would super appreciate your support:
producthunt.com/products/pro…
Gavin Ray retweeted
A new review paper highlights something that’s becoming harder to ignore: GLP-1 receptor agonists appear to have meaningful anti-inflammatory effects that even extend well beyond weight loss.
In chronic inflammatory and autoimmune skin conditions like psoriasis, hidradenitis suppurativa, and atopic dermatitis, clinicians are reporting improvements in disease activity - sometimes even before significant weight loss occurs. The mechanisms seem to involve direct effects on immune cell activity, keratinocyte function, and inflammatory signaling pathways.
GLP-1 medications could end up being viewed as some of the most broadly anti-inflammatory drugs we’ve seen in clinical practice.
Full paper here: mdpi.com/1999-4923/18/5/605
