After watching the demo videos, had to dig this old post up...
#jokingbutnot
nitter.gq/GavinRayDev/status/205…
Gavin Ray retweeted
Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude.
At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells.
Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI.
We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force.
Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.
Insane progress, hell yeah! Even more impressive given just 150 T.
Did you lift or play sports growing up?
Ah, good to know. Similarly not sure I can say it does anything yet.
I might try sublingual from Nootropics Depot since they HPLC test all their batches if no change soon
Androgens lower hepcidin. Hepcidin is the body's master iron regulator, it binds it and prevents it from entering the bloodstream
If you have LOW iron markers on TRT, you have something very odd going on as that's the opposite signal from what should be happening
Both claims can be true.
Ben is claiming that an early response to fasting is elevated GH, to shift substrate utilization towards liberated free fatty acids
You are claiming that extended fasting catabolizes muscle tissue
Neither of you are wrong
How's your pregnenolone experience been?
I added it about a week ago but can't say I've noticed anything yet.
There was a study showing oral absorption was poor and that doses of 300-500mg were required to elevate levels, been taking 400mg (200mg x 2) myself
pmc.ncbi.nlm.nih.gov/article…
Gavin Ray retweeted
I built bbtree, the foundation of databases and filesystems, and the fastest concurrent btree.
Code: github.com/XiangpengHao/bbtr…
Blog post & demo: bbtree.xiangpeng.systems/
Thorough evidence of the contrary compiled in:
"Pleiotropic effects of GLP-1 receptor agonists — a narrative review of extra-metabolic outcomes in adults"
journals.viamedica.pl/medica…
Reminds me of the guy who went to the Olympia and asked to check random bodybuilders' blood pressures:
youtube.com/watch?v=dFEid2ZR…
One of them almost had her beat: 187/118
> a blood pressure of 200/100 and a blood sugar of 500
Wow, she was really gunning for a high score, huh?
Besides: are you truly living if you're not walking around in a hypertensive crisis? 🤡
I just experienced something novel with LLM's I've never seen before:
For a single word, Gemini Argon 4 invented a term by combining a different language root with an English suffix:
> "банаl", from common Slavic "бана"-root with a Latin "l" suffix, for "banal"
> What worked? I don't have a freaking clue. If it comes back I'll be more scientific for sure.
Hey, props for being honest at least.
Awesome that you feel better.