Computational Biologist at Feng Zhang’s lab Protein/RNA/CRISPR
Boston, MA
Joined January 2013
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Really impressive accomplishment by @tanya_fesenko Fesenko and the Klaviyo engineering team 👏 Proud to see Tanya’s leadership featured here.
Read and clap at this fantastic article! 🙌 klaviyo.tech/rebuilding-even…
Thrilled to share our latest work on TIGR system at
@zhangf
lab! A special thanks to
@zhangf
for his extraordinary leadership, support, and scientific vision, and to all co-authors. Intrigued about TIGR? Follow the thread!
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…
Guilhem Faure retweeted
We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…
Guilhem Faure retweeted
Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. rb.gy/c3rdw
Thank you to @FrangiehChris, @mircoscopy, @GuilhemFaure, Rhiannon Macrae, @zhangf 1/7
Thrilled to share our latest work on Tn7 transposon at @zhangf lab! A special thanks to @zhangf for his extraordinary mentorship and support, and to all co-authors for their dedications, commitment and expertise. Intrigued about this transposon? Follow the thread!
1/N Excited to unveil Tn7 transposon target selectors study! What defines the target specificity of Tn7-like Tn to spread to MGEs & integrate back into bacterial genomes? tinyurl.com/tn7targetselecto… #transposons #Tn7 #CAST
Join the Zhang lab to explore novel biological systems! We're seeking a talented PhD/Master's level Computational Biologist to join our computational efforts: develop pipelines, design mining strategies, and curate biological systems. Apply now! tinyurl.com/45r2jj4r
Guilhem Faure retweeted
Congratulations to @thestrecker, Esra Dimircioglu, @_David_Li, @GuilhemFaure, and co on another tour de force study in @ScienceMagazine! Elegant biology & beautiful integration of diverse techniques. Still so much more to explore! See David’s tweets for details.
Excited to see our work in the ZLab @zhangf on the protease Csx29 out! Led by the amazing @thestrecker with beautiful structures driven by Esra Dimircioglu, we show that Csx29 complexed with CRISPR protein Cas7-11 (aka gRAMP) is an RNA-triggered protease. science.org/doi/10.1126/scie…
Guilhem Faure retweeted
We’re excited to report today in @nature the cryo-EM structure of the OMEGA family member IsrB in complex with ωRNA and target DNA. nature.com/articles/s41586-0…
Guilhem Faure retweeted
#CRISPR2022 begins today! Excited for all of the great discussions and learnings this week.
Guilhem Faure retweeted
CRISPR technologies are powerful gene editing tools because they are programmable. We are excited to describe 3 new programmable systems, IscB, IsrB, and TnpB, some of the most abundant genes on the planet, with potential for gene editing. @ScienceMagazine science.org/doi/10.1126/scie…
Guilhem Faure retweeted
CRISPR systems are quite diverse, including some, like CRISPR-Cas13, which target RNA. @soumya_kannan12 & @altaetran found tiny versions of Cas13b (Cas13bt) that can be used to create RNA editors small enough to fit into a single AAV for in vivo delivery. nature.com/articles/s41587-0…
Guilhem Faure retweeted
We are really excited to share our work on a new modular RNA delivery technology called SEND, built from endogenous components found in the mammalian genome. @ScienceMagazine science.sciencemag.org/conte…
Guilhem Faure retweeted
We are pleased to share a follow-up story to our study of CRISPR-associated transposases (CAST) led by Makoto Saito, @LadhaAlim, @thestrecker, and Guilhem Faure: tinyurl.com/natch326. 1/5
Guilhem Faure retweeted
New video from @IRPatNIH in which I describe our exploration of the genomic characteristics that may make SARS-CoV-2 deadly #COVID19 #coronavirus irp.nih.gov/scibites/identif…
Guilhem Faure retweeted
Excited to share STOPCovid.v2 for #COVID19 diagnostics. Grateful for collaborators who helped make this happen! nejm.org/doi/full/10.1056/NE…
@JuliaJoung @LadhaAlim @jgooten @omarabudayyeh KeithJerome @GreningerLab NamGyunKim @UWVirology @AnnWoolleyMD DebHung @brucedwalkermd @DrJLi
Guilhem Faure retweeted
Our paper leveraging machine-learning for the discovery of novel anti-CRISPR proteins is out! With @joeBondyDenomy, @eugene_koonin and others
nature.com/articles/s41467-0…
Guilhem Faure retweeted
News: NIH researchers identify key genomic features that could differentiate SARS-CoV-2 from other coronaviruses that cause less severe disease dlvr.it/RYQyGS
Guilhem Faure retweeted
Our paper about SARS-CoV-2 genomic determinants of pathogenicity is out.
Read our paper here: pnas.org/content/early/2020/…
NIH Press release: nih.gov/news-events/news-rel…
Guilhem Faure retweeted
Discovery of multiple anti-CRISPRs uncovers anti-defense gene clustering in mobile genetic elements biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Guilhem Faure retweeted
Our preprint about SARS-CoV-2 genomic determinants of pathogenicity is live (biorxiv.org/content/10.1101/…). We identified key genomic features associated with the high fatality rates and the host switch from animals to humans in coronaviruses.
