@HaemEdDocRob
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Haematology Education. Portsmouth Hospitals University Trust. Haematology Consultant. Work with fantastic colleagues. Dog lover. Football fan. All views my own.
Portsmouth
Joined June 2022
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I'm a Haematology Consultant in Portsmouth, UK, passionate about educating the next generation of haematologists and biomedical scientists. This account will keep you up-to-date and support FRCPath exam prep.
Outside of work, it's all about the dogs!
60-year-old presents with cytopenias.
Please see the linked questions.
#hematology #MedTwitter #hematology
Reference:- tinyurl.com/5n96xf5v
What is the diagnosis and likely genetic abnormality?
9%AML t(9;22)
19%AML t(15;17)
57%AML inversion 16
15%AML t(6;9)
105 votes • Final resultsWhat haematological condition is associated with these X-ray and clinical findings?
#hemepath #hematology #MedEd
See linked question
Which cytogenetic is mostly likely to be found in this condition?
See linked poll
#hematology #hemepath #frcpath
Which of these features is not a flow cytometry characteristic of CLL?
MFI - median fluorescent intensity
8%CD200 pos
56%⬆️B cell antigen MFI
12%CD23/CD5 dual expression
23%4/5 Matutes score
64 votes • Final results Dr Robert Ayto retweeted
Welcome back to the #EHA #ThinkingThursday on diagnostic criteria of #mastocytosis: were your answers correct?
Patient presents with pancytopenia - trephine below.
IHC showed cells were CD20 pos, Bcl2 neg, CD10 pos and Bcl6 pos.
What is the diagnosis?
Reference:-
bit.ly/3z3ODOf
#hematology #hemepath #pathology
Excellent - active monitoring
The patient underwent bi lateral breast implant removal and total en bloc capsulectomy. There was no capsular penetration and tumour cells penetrated the luminal side of the capsule only. CT PET showed no sites of FDG avid disease.
What treatment would you recommend?
5%Radiotherapy
10%CHEOP plus radiotherapy
76%Active monitoring
10%Brentuximab monotherapy
21 votes • Final resultsCorrect FLT3-ITD!
Which subset of patients would benefit least from Venetoxlax and Azacytidine?
#hematology #hemeonc
26%NPM1+ve, normal cyto
38%FLT3 ITD+ve, normal cyto
13%FLT3 TKD, normal cyto
23%IDH2 mutated
61 votes • Final resultsPatient presents with splenomegaly, cytopenias and fatigue. A bone marrow was performed. HE below.
What is the likely diagnosis?
#path #oncology #hemepath
bit.ly/3yYIxP0
Patient presents with night sweats, weight loss, itchiness and anaemia?
Abnormal cells stain for CD15, CD30, EBER and MUM1 but CD45-ve.
What is the cell and diagnosis?
#hemepath #MedTwitter #haematology
#hematology
bit.ly/3zowRq9
A 56 year old female presents with a left breast Seroma - she has previously undergone bi lateral breast implants. Cytology and immunocytochemistry of a suspicious cell infiltrate is seen below. See thread.
#lymphoma #hemepath #hematology
reference:-
bit.ly/3cE43kI
What is the most likely diagnosis?
AL = anaplastic lymphoma
HD = Hodgkin disease
BIA = Breast Implant Associated
40%BIA ALK-ve AL
5%HD
0%CD30+ve PTCL, NOS
55%BIA ALK+ AL
20 votes • Final resultsThe patient underwent bi lateral breast implant removal and total en bloc capsulectomy. There was no capsular penetration and tumour cells penetrated the luminal side of the capsule only. CT PET showed no sites of FDG avid disease.
What treatment would you recommend?
5%Radiotherapy
10%CHEOP plus radiotherapy
76%Active monitoring
10%Brentuximab monotherapy
21 votes • Final resultsWhich subset of patients would benefit least from Venetoxlax and Azacytidine?
#hematology #hemeonc
26%NPM1+ve, normal cyto
38%FLT3 ITD+ve, normal cyto
13%FLT3 TKD, normal cyto
23%IDH2 mutated
61 votes • Final results
