
ALT Addison's disease is characterised by reduced adrenal steroid production. Symptoms can be grouped based on steroid class (glucocorticoid: orange, mineralocorticoid: blue, and adrenal androgen: green). Cortisol deficiency results in loss of negative feedback to the hypothalamic–pituitary–adrenal axis, and a consequent rise in hypothalamic secretion of CRH and secretion of ACTH from the anterior pituitary. Increased melanin production leads to hyperpigmentation. Other features of Addison's disease include reduced quality of life, cognitive deficits, depression, anxiety, and laboratory or biochemical abnormalities. ACTH=adrenocorticotropic hormone. CRH=corticotropin releasing hormone. HRQoL=health-related quality of life. K+=potassium. Na+=sodium. T4=thyroxine. TSH=thyroid-stimulating hormone.



















