@Isa_Lucet

Lab Head Chemical Biology @WEHI_research | Structural Biologist shedding invisible 🫥 light on (Pseudo)Kinases|Drug Discovery | Promoting STEM Leadership

 Australia, Melbourne
Joined September 2021
  • Tweets344
  • Following180
  • Followers257
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Absolutely thrilled to see ProteinDJ released. Many thanks to @joshuamhardy Dylan Silke and the team Junqi Pan, Andrew Thompson, Julie Iskander, @TonyPapenfuss for their enormous amount of work, making this pipeline open source.
Josh Hardy@joshuamhardy28 Sep 2025
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.6…
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Proud of the @Isa_Lucet team from @WEHI_research , Emily park @CCeMMP , Lyn Deng , Dylan Silke, Jean-Max Mazeri, @joshuamhardy & andrew thompson, showcasing their latest research, everything Ephrin receptors, DCLK1 & Protein DJ synthetic binders at @LorneProteins.
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💫 Our new publication in @scisignal reveals insights into gastric cancer progression! Funded by @latrobe, Dr Shoukat Sterle & team found inhibiting DCLK1 reduces tumour growth and prevents cancer from reshaping its environment. Congrats to the team! 👉 tinyurl.com/onjsho
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Awesome to see this fantastic study of the elusive EphB6 pseudokinase in print at long last nature.com/articles/s42003-0… Massive congrats to star PhD student @LungYu_Liang (now in Frankfurt) who bravely took on this toughest of projects with @Isa_Lucet and me – at Melbourne, Victoria
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Many thanks to @KRogers1001 and her team @geogphotog Mike M, Lacklan W and to @DebnathGhosal and Andrew Leis for their dedicated support and to all others. Thanks to @nhmrc , Melbourne Research Scholarship and @WEHI_research for funding.
James Murphy@pseudokinase16 Apr 2024
Awesome to see this fantastic study of the elusive EphB6 pseudokinase in print at long last nature.com/articles/s42003-0… Massive congrats to star PhD student @LungYu_Liang (now in Frankfurt) who bravely took on this toughest of projects with @Isa_Lucet and me
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Thrilled about our latest Pseudokinase research published today in @CommsBio, showing EphB6 power in promoting cell cell adhesion through formation of intercellular tubes. Many congratulations to our star PhD student @LungYu_Liang.
James Murphy@pseudokinase16 Apr 2024
Awesome to see this fantastic study of the elusive EphB6 pseudokinase in print at long last nature.com/articles/s42003-0… Massive congrats to star PhD student @LungYu_Liang (now in Frankfurt) who bravely took on this toughest of projects with @Isa_Lucet and me
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Replying to @joshuamhardy
@joshuamhardy hey mate, I enjoyed your talk. TEMPO is a taking off! A really great initiative. If we can, Monash should contribute more material or content, whatever helps. Keep it up 🤘
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Isa Lucet retweeted
ARC CCeMMP@CCeMMP24 Nov 2023
@CCeMMP group photo of centre members/affiliates at #cryoz23 - a great turn out in Brisbane! And thanks to outreach committee members for coordinating our 'macromolecular' assembly photoshoot 😀 @arc_gov_au #croEM #croET (credits to @LouBrillault for the photo).
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ARC CCeMMP members enjoying a lunch break during the CRYOZ23 cryo-EM workshops. We've been learning cryo-electron tomography, modelling, and image analysis. @CCeMMP @UQ_SCMB – at St Lucia, Brisbane
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Calling scientists and chemists in Melbourne 🧑‍🔬 Coming all the way from Copenhagen, Prof Meldal will *next week* present his Nobel Prize-winning work in 'click chemistry' work to the scientific community in Parkville 🧪 Register your attendance here: bit.ly/ProfMortenMeldal
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A fantastic achievement for a home-grown Australian discovery. Congrats to WEHI #structuralbiologists, @Isa_Lucet @dr_opatel for their contribution to structure-based #drugdiscovery of #momelotinib during their time at @MonashUni in partnership with Cytopia. #WomenInScience
GSK
@GSK15 Sep 2023
#News for #investors and #media: The @US_FDA has approved our new treatment for #myelofibrosis that may address key manifestations of the disease, namely anaemia, constitutional symptoms and splenomegaly.

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Excited to share #AlphaMissense our new AI system that can classify whether genetic mutations (missense variants) are benign or harmful - a critical step toward uncovering causes of many diseases, from cystic fibrosis to cancer. In @ScienceMagazine today dpmd.ai/AlphaMissenseDH
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A shining example of innovation, showcasing the power of integrating structural biology in early drug discovery and academia/industry partnership. Kudos to the incredible teams at Monash & Cytopia. Special shoutout to the many women involved #WomenInScience
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In exciting news for Australian biotech this week, momelotinib, a drug co-invented in Melbourne by Amplia CEO, Dr Chris Burns, has been granted approval by the FDA for the treatment of myelofibrosis. Read more: bit.ly/ATX-momelotinib $ATX #biotech #innovation #FDA #drugdiscovery

In pleasant surprise for GSK, FDA approves Jakafi challenger Ojjaara in broad blood cancer use

For the JAK inhibitor momelotinib, which GSK obtained in its $1.9 billion acquisition of Sierra Oncology, a three-month delay at the FDA was worth the wait. | For the JAK inhibitor momelotinib, which...

fiercepharma.com
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Isa Lucet retweeted
EMBL-EBI@emblebi13 Sep 2023
AlphaFold has given us millions of protein structure predictions, but analysing these can be tricky due to computational limitations. Foldseek Cluster is a new algorithm that can perform structural comparisons of every #AlphaFoldDB protein prediction. ebi.ac.uk/about/news/researc…
Protein structure prediction

ALT Protein structure prediction

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I had so much fun writing this review with some of my colleagues including @prosston10 and @anwarmedc. I hope you enjoy reading it. portlandpress.com/biochemj/a… Thanks @Biochem_Journal for inviting me to write this #RandomActsOfKinase

How many kinases are druggable? A review of our current understanding

There are over 500 human kinases ranging from very well-studied to almost completely ignored. Kinases are tractable and implicated in many diseases, making them ideal targets for medicinal chemistry...

portlandpress.com
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Isa Lucet retweeted
GRAS Lab@GrasLab31 Aug 2023
After months of preparation it is D day for our conference on #LongCOVID in Melbourne. Today we are coming as a community with patients, healthcare workers, researchers and policy makers to work together to advance our understanding of the disease, to provide better care.
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Many congratulations Alan. Very fortunate to be at WEHI.
WEHI Director@WEHI_Director31 Aug 2023
It’s a tremendous honour to step into the acting director shoes @WEHI_research. Working alongside my acting deputies @BlewittMarnie and @srpasricha, our staff, students, collaborators and supporters, I’m looking forward to the exciting journey ahead. - Alan Cowman
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Many congratulations @BlewittMarnie @srpasricha too for your appointments as Deputies.
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It’s a tremendous honour to step into the acting director shoes @WEHI_research. Working alongside my acting deputies @BlewittMarnie and @srpasricha, our staff, students, collaborators and supporters, I’m looking forward to the exciting journey ahead. - Alan Cowman
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