Computational Biologist at Newcastle University and visiting scientist at the Sanger institute. 3D bio-printing enthusiast
Joined January 2011
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Enter digital twins: a transformative approach. By crafting unified manifolds with RWD, we're fast-tracking the journey to personalised aging models. This transcends traditional timelines, opening doors to real-time insights and interventions. #DigitalTwins #Bioinformatics 3/3
Aging research's big hurdle? Time. Experiments take years. But integrating RWD with multi-omic atlases changes the game. We'll be crafting a paradigm that accelerates insights into somatic evolution and potential interventions, with unprecedented precision. #AgingResearch 2/3
Thrilled to announce my May start at @agecurve! The challenge: integrating RWD with expanding atlases, crafting unified manifolds across multiomic landscapes. 👉 Unlocking insights into somatic state evolution and aging. #ComputationalBiology #DigitalTwins #SingleCell 🌐 1/3
happy to announce that @IssacEGoh is joining @agecurve as a senior computational biologist full time from May, Issac, currently at @HaniffaLab and a visiting scientist at @sangerinstitute, is a multitalented individual who aced the technical interview and he'll be joining us at #Cambridge @ideaSpaceCity office, please see thread below on this beautiful #SingleCell @humancellatlas @ScienceMagazine study dissecting the role of human yolk sac in haematopoiesis where Isaac was joint first author xitter.cf/HaniffaLab/statu…
Issac Emmanuel Goh 🇺🇦 retweeted
Fantastic study revealing several new functions of the human yolk sac during development, including monocyte-independent production of macrophages!
Congratulations @IssacEGoh @BottingRachel @Muzz_Haniffa an co-authors 👏👏👏
New in @Science! 🎊
Our #Developmental @humancellatlas study (bit.ly/yolk_sac) uses #SingleCell profiling to map the human yolk sac, pivotal for embryonic survival & first prenatal blood and immune cells. Data-portal: bit.ly/YSportal 👈
[1/12] 🎥 by @megumi4952
Issac Emmanuel Goh 🇺🇦 retweeted
IMO this must be done in all comp bio papers. Without annotations, many model explanations in comp bio papers are very hard to follow. When explaining many inputs in the likelihood or many regularisation terms - you need to label what they mean. Easier to read -> more citations.
Issac Emmanuel Goh 🇺🇦 retweeted
We also identify pre-specified TREM2+P2RY12+ microglia-like cells in the YS (transcriptionally enriched in brain microglia signature)
Microglia-like cells have also been observed in pre-natal gonads and skin (@emmamarydann et al & @roserventotomo et al)
📷 by Liz Tuck
[6/12]
ALT Microscopy image showing the presence of a P2RY12 expressing macrophages in the yolk sac
Issac Emmanuel Goh 🇺🇦 retweeted
We observe a pre-AGM accelerated pathway to macrophage differentiation in the YS prior to monocyte emergence (also in iPSC scRNA-seq @ClaraAlsinet et al)
Macrophages in the YS post-AGM are from proliferating macrophage pool and monocyte differentiation
[5/12]
ALT Graph showing an inferred trajectory of the early yolk sac bypassing the monocyte stage to directly produce macrophages via an accelerated pathway
Issac Emmanuel Goh 🇺🇦 retweeted
We find distinct waves of HSPC (red👇) lineage potential for different blood/immune cells before/after AGM contributions to haematopoiesis in YS. Our data are consistent with definitive HSPC predominance over primitive by 8 post conception weeks (@VincenzoCalvan3 et al)
[4/12]
ALT Graph showing distinct waves of stem cells in the yolk sac and the varied pools of blood and immune cells they make pre and post AGM.
Issac Emmanuel Goh 🇺🇦 retweeted
We detail haematopoietic stem progenitor (HSPC) emergence from hemogenic endothelium, also observed in iPSC scRNA-seq data (@ClaraAlsinet et al) similar to aorta-gonad-mesonephros (AGM)
[3/12]
ALT Graphs showing the inferred emergence of the first blood and immune stem cells from specialised endothelium in the human yolk sac, paralleled in a model iPSC system developed by @ClaraAlsinet et al.
Our manuscript was just published in Science!
Blessed to have co-led with the brilliant @BottingRachel, working with friends and collabs at @HaniffaLab, @sangerinstitute @Cambridge_Uni!
Read about how we uncover the first emergence of blood/immune cells in human embryonic life!
New in @Science! 🎊
Our #Developmental @humancellatlas study (bit.ly/yolk_sac) uses #SingleCell profiling to map the human yolk sac, pivotal for embryonic survival & first prenatal blood and immune cells. Data-portal: bit.ly/YSportal 👈
[1/12] 🎥 by @megumi4952
Issac Emmanuel Goh 🇺🇦 retweeted
New in @Science! 🎊
Our #Developmental @humancellatlas study (bit.ly/yolk_sac) uses #SingleCell profiling to map the human yolk sac, pivotal for embryonic survival & first prenatal blood and immune cells. Data-portal: bit.ly/YSportal 👈
[1/12] 🎥 by @megumi4952
Issac Emmanuel Goh 🇺🇦 retweeted
Probing the haem compartment further, we detail haematopoietic stem progenitor cell (HSPC) emergence from hemogenic endothelium, also observed in public yolk sac iPSC scRNA-seq (@ClaraAlsinet et al rdcu.be/cTfOt) similar to aorto-gonado-mesenephros (AGM)
[3/9]
ALT FDG overlaid with PAGA showing trajectory of HE transition to HSPC in YS scRNA-seq data (n=3; CS10, 11 and 14; k=2,262) (top) and iPSC-derived HSPC scRNA-seq data (n=7, k=437) (21) (bottom), with feature plots of key genes (IL33, ALDH1A1) involved in endothelial to hemogenic transition
Issac Emmanuel Goh 🇺🇦 retweeted
New preprint alert! 📢🥳
Using multiomic profiling of #SingleCell data we integrated and analysed ~180k cells from first trimester human yolk sac (YS)
Our investigations recovered cells from the contents, membrane & vitelline duct [see vid below]
Here's what we learnt [1/9]👇🏾
Issac Emmanuel Goh 🇺🇦 retweeted
Our data are consistent with definitive HSPC predominance over primitive by 8 PCW (@VincenzoCalvan3 et al rdcu.be/cTgFF)
We find differential linage potentials before and after AGM contributions to haematopoiesis in YS
[4/9]
ALT Circular plots showing relative absorption probabilities of lineage-state transition between primitive HSPCs in the YS pre-AGM (CS10-11) (left) and primitive and definitive HSPCs in the YS post-AGM (>CS14) (right). Colour indicates the HSPC population density as a z-scored kernel density estimation (KDE) score and the position of HSPC population densities indicate respective lineage priming probability between Macrophage, lymphoid (NK and B lineage), erythroid and MK terminal states.
Issac Emmanuel Goh 🇺🇦 retweeted
Led by @BottingRachel @IssacEGoh 👏🏾 An amazing effort from this duo! Give them a follow
Co-authored by @Antony_Rose_ @SimSci9 @Yorick_Gitton @emilyxsx @QuirogaLondono @MichaelMather6 @Dave_Horsfall @enjywenjy @Olu_GH @ClaraAlsinet @BayanneOlabi @MohiMiah @AdmaneChloe
[8/9]
#FirstAidUkraine has been working closely with @NewcastleMedSch to setup various schemes including salary sacrifice and other student-led fund raising initiatives. Watch this space.
Many of us have friends or family in Ukraine. We cannot sit idly by as we hear of lives destroyed everyday.
Please help us by:
- Donating to #FirstAidUkraine or any DEC member charities.
- Share our cause
- Find out more on how you can help: facebook.com/groups/52338514…
#FirstAidUkraine is back online with a JustGiving page! @OlyaGum3 and I are now collaborating with MedicalAidUkraine for logistics and supply pipelines into Ukraine.
Please donate & share to help send Medical supplies from 🇬🇧 to 🇺🇦!
justgiving.com/crowdfunding/…
