Ivan Xia (@IvanFXia) header
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Ivan Xia

@IvanFXia

Postdoc in Dr. Stefania Nicoli’s lab at Yale University and working on neurovascular development and diseases by using zebrafish model

 New Haven, CT
Joined March 2020
  • Tweets414
  • Following516
  • Followers290
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Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)Photo by Ivan Xia (@IvanFXia)
Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By @janetiwasa
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tRNA intron-derived small regulatory RNAs fine-tune gene expression under oxidative stress dlvr.it/TJ91YW
Image from Molecular Cell (@MolecularCell)
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New! Online now: MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling dlvr.it/TJ8xtX
Image from Cell Metabolism (@Cell_Metabolism)
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💫NEW: @AnuHemalatha, @valentatormenta, @RachelPerryLab1 & co track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin and find that maintaining a robust redox ratio is key to clonal prevalence. nature.com/articles/s41556-0…
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Nature Cell Biology - Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells....

nature.com
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Lysosome interaction with other organelles may be linked to pulmonary hypertension. Learn more in a new #SciencePerspective: scim.ag/4jwY5A0
Image from Science Magazine (@ScienceMagazine)
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📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper:
Image from Lucas Harrington (@CRISPR_LuCas)
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🎉 Welcome, New NAVBO Members! 🎉 We’re excited to introduce our newest members to the #NAVBO community! A warm welcome to all of you—we’re thrilled to have you on board! Explore the benefits of NAVBO membership here: navbo.org/membership-benefit… #VascularBiology
Image from NAVBO (@vascularbiology)
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👋 Are you a passionate communicator? NAVBO Communications Committee is looking for volunteers to join our team and make a difference! 🌟 Apply by March 3, 2025: Send your CV to [email protected] or [email protected]. Seize this opportunity to have a positive impact!
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Mitochondria are transferred between cells, tissues and organs, particularly in response to stressors New exciting layer of mitochondrial biology showing the importance of cell-cell interactions and that mitochondria convey information/signal widely nature.com/articles/s42255-0… 🧵
Image from Martin Picard (@MitoPsychoBio)
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Fate specification triggers a positive feedback loop of TEAD–YAP and NANOG to promote epiblast formation in preimplantation embryos Read this Research Article by Naoki Hirono, Masakazu Hashimoto, Hiromi Shimojo & Hiroshi Sasaki: journals.biologists.com/dev/…
Figure 1 (A) Representative immunofluorescence images of the ICM region of blastocysts collected at sequential developmental stages. Hoechst 33342 (nuclei), NANOG, GATA6, and YAP are shown in grayscale, magenta, cyan, and green, respectively. The total number of cells in the embryo is indicated in the Hoechst image. Dashed lines indicate the ICM. Arrowheads mark DP cells co-expressing NANOG and GATA6. Scale bar: 20 µm.

ALT Figure 1 (A) Representative immunofluorescence images of the ICM region of blastocysts collected at sequential developmental stages. Hoechst 33342 (nuclei), NANOG, GATA6, and YAP are shown in grayscale, magenta, cyan, and green, respectively. The total number of cells in the embryo is indicated in the Hoechst image. Dashed lines indicate the ICM. Arrowheads mark DP cells co-expressing NANOG and GATA6. Scale bar: 20 µm.

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Application of a ImageJ-Based Method to Measure Blood Flow in Adult Zebrafish and Its Applications for Toxicological and Pharmacological Assessments #zebrafish #ImageJ #bloodflow #toxicoloy mdpi.com/2079-7737/14/1/51
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So happy that my first day @FMIscience coincided with the publication of this paper. nature.com/articles/s41556-0… . Thanks to @yaledailynews and @YaleCancer for highlighting : news.yale.edu/2025/01/06/tra….
Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations

Nature Cell Biology - Hemalatha et al. track the endogenous redox ratio (NAD(P)H/FAD) with live imaging in the mouse skin to study the interface of wild-type stem cells with oncogenic mutant cells....

nature.com
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New findings in mice have uncovered a crucial mechanism linking neuronal activity to mitochondrial function, researchers report in Science, revealing a potential pathway to combat age-related cognitive decline. 📄: scim.ag/3DjdseC #SciencePerspective: scim.ag/4gZZMEb
Image from Science Magazine (@ScienceMagazine)
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Iron oxide nanoparticles containing a nitric oxide-responsive cleavable linker allow in vivo magnetic resonance imaging and the quantification of nitric oxide with high sensitivity and selectivity in mice. nature.com/articles/s41563-0…
Responsive probes for in vivo magnetic resonance imaging of nitric oxide

Responsive probes for in vivo magnetic resonance imaging of nitric oxide

Nature Materials - Iron oxide nanoparticles containing a nitric oxide-responsive cleavable linker allow in vivo magnetic resonance imaging and the quantification of nitric oxide with high...

nature.com
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Excited to share our lab's first preprint: we used spatial transcriptomics to dissect how aging disrupts the cycling ovary! 🧵 This was an incredible team effort w/ @jenngarrison @Tammyinlab @davidsebfischer AlisonKochersberger @RuthRaichur @sophiamszady
Image from Hattie Chung (@hattaca)
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Top citations 2024: #13🏆✨ Jens Brüning (@MPI_Metabolism) and co-authors describe how reciprocal activity of #AgRP and #POMC neurons regulates #feeding and #metabolism.🧠🍽️ nature.com/articles/s42255-0…
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism

Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism

Nature Metabolism - De Solis and Del Río-Martín et al. investigate the reciprocal interplay between AgRP and POMC neurocircuits that governs the precise regulation of food intake and...

nature.com
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Activity-dependent enhancer RNA produces hybrid DNA:RNA R-loop structures that support three-dimensional chromatin looping between enhancer and promoter and rapid Npas4 gene induction in the brain. science.org/doi/10.1126/scie…
A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation

A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation

Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations...

science.org
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Thrilled to share that our paper nature.com/articles/s41586-0… is featured in a fantastic Nature News & Views piece by @ThomasTueting! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. nature.com/articles/d41586-0… 👀👉 rdcu.be/d3cRz
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

Nature - Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

nature.com
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Brain vascular imaging in live animal… 3D-ULM rocks ! Great talk by Olivier Couture at the « folle journée de l’anévrisme »
Image from vion anne-clemence (@AnCVion)
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🚨 Exciting opportunities in the Ghersi lab! 🚨 I am thrilled to announce that my lab at CHU Sainte-Justine in Montreal is actively seeking new motivated PhD students and postdoctoral fellows to join us! Don't hesitate to apply : [email protected]
Image from Joey Ghersi (@joey_ghersi)
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