@JakeTHerb

MD/PhD student @SinaiMSTP #doubledocs 🔬🩺 @DukeU 18' | Gut ↔️ Liver axis in #PSC and #IBD he/him | views my own

 New York
labs.icahn.mssm.edu/cholab/
Joined October 2019
  • Tweets280
  • Following823
  • Followers402
14Media
So excited to finally share my PhD work, out today in Cell! Huge thank you to my mentor Joel Blanchard, co-mentor Alison Goate, and all of the amazing co-authors who made this work possible.
Joel W. Blanchard, PhD@JoelWBlanchardSep 24
Blood vessels in the brain deteriorate in Alzheimer’s, especially in APOE4 carriers. But what drives this damage? Our new study, out now in @CellPressNews , uncovers a mechanism linking APOE4 to vascular fibrosis and amyloid accumulation in the brain. 🧠🧬
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Jake Herb retweeted
APSA@A_P_S_ASep 18
New in @JCI_insight NIH F30 applications are up 39% since 2017, but success rates have dropped to 32%. We surveyed 256 physician-scientist trainees to find out why. Read: insight.jci.org/articles/vie… @bthomasZOU @_CynthiaTang @DaveArnoldLab @Duke_Anesthesia @Mizzou_MDPhD @WashUDPS
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Replying to @MountSinaiNYC
@MountSinaiNYC has been ranked #5 worldwide in research hospitals by @Nature. nature.com/nature-index/supp…
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Our new perspective piece in @NatureAging from lab of @MiriamMerad @SinaiImmunol highlights the fundamental role for aging-related changes to resident tissue macs and myelopoiesis in both healthy aging and in cancer: nature.com/articles/s43587-0…

Restoring resident tissue macrophages to combat aging and cancer

Nature Aging - Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases,...

nature.com
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See this important perspective by @IcahnMountSinai's @taliaswartz on how to sustain excellence and success in biomedical training during these turbulent and uncertain times. nature.com/articles/s41591-0…

Perspectives of biomedical trainees during a time of policy disruption

Nature Medicine - Perspectives of biomedical trainees during a time of policy disruption

nature.com
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🚨 New research from @YatrikShahLab shows a type of cell death tied to iron may play a big role in gut diseases like Crohn’s and colitis. Check it out! medschool.umich.edu/health-l…

Research links iron-mediated cell death and inflammatory bowel disease

New basic science insights into programmed cell death could offer relief for inflammatory bowel disease. The University of Michigan study reveals a connection between lipid reactive oxygen species,...

medschool.umich.edu
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Scientists @CellPressNews reviewed 408 YouTube clips of sleeping cats and found 2/3 curled up on their left side. Here’s the neuroscience behind why:🧵 (Please watch their video abstract I put on the last post - it’s 100% worth it)
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Jake Herb retweeted
Gut Journal
@Gut_BMJ24 Jun 2025
#GUTVideo from the paper by Guisado et al on "Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease" via bit.ly/43UW4GK Paper via: bit.ly/438XpJy @Felix_Chuang240 @mountsinaiGI #IBD #StemCellTransplantation #CrohnsDisease
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From genetic associations to environmental triggers in PSC. Our EBV-paper is out in @NatureMedicine today. nature.com/articles/s41591-0…

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Nature Medicine - Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing...

nature.com
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We’re excited to announce that MSTP student Jerrel Catlett been recognized by the American Association for Cancer Research. This award funded his attendance and presentation at the 2025 American Association of Cancer Research Annual Meeting in Chicago last week.
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Congratulations to the @A_P_S_A advocacy team on this new piece highlighting mental health challenges and solutions in medical scientist trainee populations. @SinaiMSTP nature.com/articles/s43856-0…
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I'm very excited to be named one of the HRI Pioneers! I look forward to sharing my work and connecting at HRI 2025.
HRI Pioneers@HRIPioneers11 Feb 2025
We are excited to invite 27 talented graduate students to the #HRI Pioneers workshop in conjunction with the ACM/IEEE International Conference on Human-Robot Interaction! @HRI_Conference Please welcome our #HRIPioneers2025 cohort: hripioneers.org/participants
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I am thrilled to share a new story, co-led w @MeriemBelabed from @MiriamMerad lab @SinaiImmunol @IcahnMountSinai @TischCancer on our discovery of how cholesterol is used by DCs to undergo maturation. See our new study @NatImmunol : nature.com/articles/s41590-0…
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Excited to share my PhD work with @BogunovicLab in @Nature! We highlight the importance of monoallelic expression on the penetrance of genetic disease. nature.com/articles/s41586-0… @KidsAtColumbia @SinaiImmunol @SinaiMSTP @IcahnMountSinai #InThoseGenes

Monoallelic expression can govern penetrance of inborn errors of immunity

Nature - Somatically determined preferential allelic expression of select genes that when mutated cause inborn errors of immunity corresponds with disease phenotypes, suggesting that the penetrance...

nature.com
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Jake Herb retweeted
APSA@A_P_S_A16 Dec 2024
🚨 Reminder! 🚨 Considering starting a family during your MD-DO/PhD training? 🍼👩‍⚕️ Join us this Thursday, Dec 19, from 7-8PM ET for a FREE webinar with trainee-parents who’ve made it work! Gain insights on work-life balance, childcare, and more. Register: tinyurl.com/APSAWebinars
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New from us: A clinical trial of vancomycin was associated with reduction in colitis activity in PSC. We also studied the associated changes in microbiome, transcriptomic and metabolic readouts @NabilQuraishi @bhmullish @WvSchaik @jfergus75 academic.oup.com/ecco-jcc/ad…

Open Label Vancomycin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Improved...

AbstractBackground. We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV

academic.oup.com
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Does the gut #microbiome predispose patients to immunotherapy-related colitis? Our study in @JExpMed explores the #microbiota before, during, and after #colitis induced by #cancer #immunotherapy in a prospective cohort. Read here: hubs.la/Q02_r1nl0 #MedTwitter #GITwitter

Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis

Pretreatment gut microbiomes of immunotherapy-related colitis patients drive worse colitis in susceptible mice compared with non-colitis cancer immunothera

rupress.org
Journal of Experimental Medicine@JExpMed12 Dec 2024
.@Shang_Joa, @DavidFaleckMD, @jeremiahfaith1 et al. @IcahnMountSinai report that pretreatment gut #microbiomes of #immunotherapy-related colitis patients drive worse #colitis in susceptible mice compared with non-colitis cancer immunotherapy microbiomes. hubs.la/Q02_r1nl0
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Jake Herb retweeted
Immunity@ImmunityCP11 Dec 2024
Beyond classical immunity: Mast cells as signal converters between tissues and neurons dlvr.it/TGkVzV

Beyond classical immunity: Mast cells as signal converters between tissues and neurons

Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can...

cell.com
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And then, @JakeTHerb from Mount Sinai will present a preprint from Marc Rothenberg’s lab about a neuroimmune circuit that regulates allergic inflammation in the esophagus. biorxiv.org/content/10.1101/…

Identification of a Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus

Eosinophilic esophagitis is a chronic food antigen-driven allergic inflammatory disease associated with symptoms involving the nervous system such as refractory pain. Yet, the role of the nervous...

biorxiv.org
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