GPCRs in neural circuit function
Jupiter, FL
Joined May 2019
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Kirill Martemyanov Lab retweeted
What do you get when #NationalProteinDay and #NationalPokémonDay meet? Pikachurin. ⚡
A 2023 @scisignal study solved the structure of this extracellular protein that plays an essential role in vision.
In the retina, light is perceived by photoreceptor cells that transmit signals to neurons called bipolar cells, which in turn relay the signal to the retinal ganglion cells that form the optic nerve. The activation of bipolar cells by photoreceptor cells depends on the precise positioning of multiprotein complexes on the surfaces of both cell types.
Pikachurin is an extracellular matrix protein that bridges these complexes by making contacts with the membrane protein dystroglycan on the photoreceptor cell and the receptor GPR179 on the bipolar cell, thus ensuring that photoreceptor cells are properly aligned with the bipolar cells.
Learn more: scim.ag/41dTWIP
Kirill Martemyanov Lab retweeted
The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
Kirill Martemyanov Lab retweeted
Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it.
biorxiv.org/content/10.1101/…
Kirill Martemyanov Lab retweeted
As shown recently a single point mutation in G protein alpha subunit yields a stable complex without the use of stabilizing nanobodies!
nature.com/articles/s41467-0…
Kirill Martemyanov Lab retweeted
@jbiolchem symposium @ASBMB meeting kicked off by @ChiefEditorJBC , and composed by three outstanding talks by editors and scientists @HenrikDohlman @DrBrianStrahl @KLabGPCR.
Kirill Martemyanov Lab retweeted
Exciting news! Our department invites applications for Assistant Professor Positions
#pain #somatosensation #Substanceusedisorders
#CAMed
AcedemicJobsPosition ID:Boston University Chobanian & Avedisian School of Medicine-Pharmacology-Physiology & Biophysics-AP1 [#27116]
Kirill Martemyanov Lab retweeted
Do have an interest in #GPCR signaling? Did you always want a good assay that worked in your favorite cell type? Even with endogenous GPCRs? This might be for you. We got some surprises about endogenous GPCR behavior. Remi + Marcin led, with help from many biorxiv.org/content/10.1101/…
Kirill Martemyanov Lab retweeted
MPFI enthusiastically welcomes @LinTianPhD as our new Scientific Director. Dr. Tian brings exciting new approaches in neuroengineering, creating novel tools that support the development of fast-acting therapies for neurological and psychiatric conditions. mpfi.org/internationally-rec…
Kirill Martemyanov Lab retweeted
In this week’s Editors’ Choice piece, we highlight the work of Park, @MGMlab, and @KLabGPCR in @MolecularCell, showing that the protein GINIP inhibits one arm of G protein signaling while promoting the other.
Read a summary in #ScienceSignaling: scim.ag/3m4
Kirill Martemyanov Lab retweeted
Our review on how #biosensors decode #spatiotemporal #GPCR #signaling is out. In addition to our own recent work, we cover exciting technology from @KLabGPCR @Michel_Bouvier @jinzhanglab @TsvetanovaLab and many other twitterless labs :-)
Free access: authors.elsevier.com/a/1hFS3…
Kirill Martemyanov Lab retweeted
With @CathBelzung, Florence Desprez, Thibault Laboute ! 📸 @UngDevinaC ! Discover their last results on NDD ! #NeuroFrance2023 @UnivTours @InsermGrdOuest @Inserm @ITMO_neuro @FacmedTours @AgenceRecherche @RCValdeLoire @CHRU_Tours
Kirill Martemyanov Lab retweeted
Here we go, #ASPET2023
@KLabGPCR @orlandi_cesare @DessauerCarmen Michelle Kimble and Brian Muntean
Kirill Martemyanov Lab retweeted
The symposium will be held on May 3, 2023, at the Broad Institute in Cambridge, Massachusetts.
Hit the link to learn more now!👉bit.ly/KirillS2S
Kirill Martemyanov Lab retweeted
Welcome @KLabGPCR to give a #hilifewebinars presentation on the topic "Terra Incognita of Neuronal GPCR signaling".
Hybrid seminar 6.2.2023 at 14.15 (UTC+2).
👉 Hall 1041, Biocentre 2, Viikinkaari 5
👉 Zoom: helsinki.zoom.us/j/620237196…
@HelsinkiUniMed @LifeSciHelsinki
Kirill Martemyanov Lab retweeted
[Pls RT] Looking for postdocs interested in doing cell signaling research in a collaborative lab in Boston. Different projects w/ different approaches/ models/ topics. Salary above NIH scale, relocation bonus, full benefits like staff employees. Details: nature.com/naturecareers/job…
Kirill Martemyanov Lab retweeted
Registration is now open for Sunposium 2023, our biennial conference featuring three incredible days of neuroscience. Want to add your name to this list of exceptional scientists? We're now accepting abstract submissions! Learn more and register -
bit.ly/3Wc9fOO
Kirill Martemyanov Lab retweeted
It is my pleasure to announce the @FASEBorg SRC Biology and Chemistry of Vision, to be held at the Loews Ventana Canyon Resort in Tucson, AZ from June 25-29, 2023. Please consider this a Hold-the-Date while Co-Organizer @PRRobinson88 and I work out the schedule. Please RT!
Kirill Martemyanov Lab retweeted
First day in the lab as a PI @SBRC and Assistant Professor @UManitoba where we’ll study GPCR pharmacology & neuropsychiatric disease! Excited to begin filling this lab with colleagues to share in GPCR enthusiasm - passed down to me from my mentors @FergusonottawaS and @KLabGPCR!
