Post doc @ Rockefeller University NYC. Interested in natural product evolution.
Joined January 2021
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We untangled the weird evolution of an NRPS. For the NRPS people. Check out the supps and you can see in detail how NRPS extend and shrink. I think its very beautiful. For the evolution people: Endless peptides form most beautiful.
Haven't used this is in a while, but a new paper from the group is a good excuse. This is monster of a paper from Sebastian Kaiser about the evolution of non-ribosomal peptides. nature.com/articles/s41559-0…
Sebastian Kaiser retweeted
And here is the research briefing for our recent natural products paper. nature.com/articles/s41559-0….
Sebastian Kaiser retweeted
And here is the press release for our natural products paper. It does a much better job explaining what we did than my thread:
mpi-marburg.mpg.de/1619988/2…
Paper here:
nature.com/articles/s41559-0…
Sebastian Kaiser retweeted
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by @JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can.
biorxiv.org/content/10.1101/…
It was a formative experience to be in America for the first time and to attend the #GRC on Evolution. I had the chance to give a talk at the GRS and present my poster at the GRC. I received valuable feedback and also had the pleasure of meeting some truly inspiring people.
Sebastian Kaiser retweeted
super exciting work by our former student @tretyacv (now with Pilpel lab)! using unique ML assisted pipeline they identified thousands non-genetic mutations in large proteomic data, showing another layer of diversity that human proteome consist of 🪄
biorxiv.org/content/10.1101/…
Sebastian Kaiser retweeted
New paper from the lab from @SriramGarg. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important. academic.oup.com/mbe/advance…
Sebastian Kaiser retweeted
An enormous amount of work went into this from so many people: our leadership at the MPI and the university, the scientific team, the administrative support and of course all the scientists that did the science that laid the foundations. What a rush to be part of this!
📢We are thrilled that our Microbes for Climate (M4C) Cluster of Excellence has been selected for the 2025 Excellence Strategy! 🥳 Together with Philipps University Marburg, we're looking forward to some exciting #microbe research! @maxplanckpress @BangeBalcony #synbio #research
Sebastian Kaiser retweeted
📢We are thrilled that our Microbes for Climate (M4C) Cluster of Excellence has been selected for the 2025 Excellence Strategy! 🥳 Together with Philipps University Marburg, we're looking forward to some exciting #microbe research! @maxplanckpress @BangeBalcony #synbio #research
Sebastian Kaiser retweeted
Nature research paper: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome
go.nature.com/3FJLuu0
Sebastian Kaiser retweeted
I am more than happy to see this story to be out. We show another inhibition manner to Acetyl-CoA synthetase. Great thanks to mentor Gert and Joh. also great thanks to my best old friend Yifei as well as all contributed 🍀🍀🍀
A wonderful piece of work by Liu Zheng - enjoy the reading: Regulation of acetyl-CoA biosynthesis via an intertwined acetyl-CoA synthetase/acetyltransferase complex | Nature Communications @Uni_MR @mpi_marburg nature.com/articles/s41467-0…
Sebastian Kaiser retweeted
Just appeared: How knowing physics helps to understand bacterial strategies of resource allocation. Congratulation @LisevichIra on this paper! nature.com/articles/s41467-0…
It was a lot of fun organizing this year’s retreat for the @IMPRS_Mic of the @mpi_marburg. I was responsible for organizing the industry session. Big thank you to @BASFAgroand and @IQVIA_global for taking the time to visit us and share potential career paths with us.
Sebastian Kaiser retweeted
~5y ago, @BDragonMaster @serina_robinson @marnixmedema & I teamed up to make a better NRPS A-domain specificity predictor. @Challis_Group & others joined along the way to add some very cool insights.
Very proud of this work. Check it out now on biorxiv! doi.org/10.1101/2025.01.08.6…
Sebastian Kaiser retweeted
Excited to share my first paper as a postdoc with @KaHochberg @mpi_marburg! We've made some fascinating discoveries about the evolution of animal stem cells in colab with @jauchr and @deMendoza_Alex. 🧬🔬
Link: nature.com/articles/s41467-0…
(1/n)
Sebastian Kaiser retweeted
Exciting news 🚀 @MathiasGirbig and @KaHochberg helped showing that essential proteins for animal #stemcell regulation are much older than previously thought, dating back over 700 million years. Check it out👓
mpi-marburg.mpg.de/1450571/2…
The conference at #EMBOEvoEco a few weeks ago was fantastic! This time, the focus was on mechanisms in evolution, and I had the chance to exchange insights on my research with brilliant evolutionists. Now the story comes to an end and I hope to share more about it with you soon.
Sebastian Kaiser retweeted
🌍🌱🔬#M4Cmonday: Explore ancient microbes’ biochemistry with Georg Hochberg @MPI_Microbiology! Learn how these insights reveal the evolution of CO2 conversion pathways that dominate Earth today.🌱🔬#EvolutionaryBiochemistry #MicrobesForClimate #Exzellenzstrategie
Sebastian Kaiser retweeted
Off to a good start at #EMBOEvoEco✨😀
Yesterday was the first day and @HarmitMalik held the keynote lecture about fitness landscapes in host-virus interactions. 🦠
In the evening the participants had fun at the science pub quiz and the poster session sneak peek 🖼️🍸
Sebastian Kaiser retweeted
Our latest preprint: @Sriramgarg calculate a general substitution matrix for structural phylogenetics and used it to root the tree of life.
biorxiv.org/content/10.1101/… 1/n
