Microbiologist 👨🏾🔬🇸🇬 Researching Down Under 🇦🇺 Mucosal Polyclonal 🧩 Covid Pundit 😷 Semen Demon 😈 Post Doc @AmyWChung lab @TheDohertyInst
Melbourne, Victoria
Joined May 2020
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Our follow-up study on IgG4 in blood and saliva after 4 x COVID-19 mRNA vaccines is out on eBioMedicine 🧪
1)🧵So how does IgG4 influence responses to Omicron (XBB.1.5 and JN.1) and Sarbecoviruses (from bats, pangolins)? What epitopes are being targeted?
authors.elsevier.com/sd/arti…
Grateful for the opportunity to give my 10 cents on mucosal immunity, scientific collaborations and nasal sprays 🧑🏽🔬👃💦
🎙️ New #ESWIAirborne podcast explores what reported case numbers can't tell us, and how we can build a better picture of infection spread through alternative testing methods, and reading the hidden signs of an infection. With @drjanebarratt. Listen here 🔗 eswi.org/activities/podcasts…
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Kevin John 🧪🧩 retweeted
WASHINGTON (AP) — Democrat Jasmine Clark wins election to U.S. House in Georgia's 13th Congressional District.
Kevin John 🧪🧩 retweeted
Our BA.3.2.2 study is now published in Nature Microbiology!
Counterintuitively, we found that ancestral-strain immune imprinting protects against BA.3.2.2 through IGHV3-53/66 Class 1 antibodies, helping explain why BA.3.2.2 selectively infects children.
doi.org/10.1038/s41564-026-0…
Kevin John 🧪🧩 retweeted
Fantastic to see this study published! An incredible amount of work by @jagaevert, @PGTimmune & team to unravel how infection history shapes CD8 T cell cross-reactivity. Important insights into how our past infections affect future immune responses. Infection history matters! 🦠
How does our history of influenza infections shape the ability of CD8+ T cells to recognize new viral variants? Our new paper in @CellReports examines these questions using influenza-specific CD8+ T cells! 🧵⬇️ (1/12)
cell.com/cell-reports/fullte…
Kevin John 🧪🧩 retweeted
NHMRC-supported researchers have found that cannabis hospitalisations in Victoria increased by 49% between 2013 and 2023.
Read more here: ow.ly/NPCL50ZXq11
Kevin John 🧪🧩 retweeted
YouTuber @MouldS hypothesized that a circular loop of chain would exhibit circumferential waves as it rotated in the absence of external forces, flowing through its own shape.
In gravity, this creates the chain fountain effect, popularized with his science videos. Aboard the ISS, I helped test his theory!
These loops were made from beaded chain and our EVA French clips used to tie things down during spacewalks. I wore nitrile gloves to prevent the chain from sticking to my fingers. It took many tries to produce this!
A full video of our findings is now posted to his channel, which I have linked in the comments.
Kevin John 🧪🧩 retweeted
SARS-CoV-2 saltation variant PJ.2.1 has raised concerns over another JN.1-like event.
Here we found:
1. PJ.2.1 shows markedly higher ACE2 binding.
2. PJ.2.1's antigenicity remains comparable to the JN.1 family.
3. No increased immune evasion against human plasma.
While PJ.2.1 currently lacks the immune evasion capabilities of other contemporary strains (XFG, PQ.16.1.1, BA.3.2.2...), its robust baseline receptor-binding strength mirrors the early evolutionary trajectory of BA.2.86 to JN.1, necessitating continued genomic, epidemiological, and virological surveillance of the PJ.2.1 lineage.
Details can be found in the recent BioRxiv manuscript:
biorxiv.org/content/10.64898…
Kevin John 🧪🧩 retweeted
TCR specificity prediction is advancing rapidly. The central question is not only which TCR sequence recognizes an antigen, but also which TCR pairings make recognition possible & where is the binding boundary? Our new paper tackles this question. 🧵
science.org/doi/10.1126/scie…
Kevin John 🧪🧩 retweeted
Nature research paper: Robust inference and correlates from genetic associations with personality
go.nature.com/461KmvG
Kevin John 🧪🧩 retweeted
1/ 🧵Thrilled to share that our new paper was just published at @ScienceTM @aaas ! 🎉
We show how the complement system boosts the ability of antibodies to neutralize SARS-CoV-2, especially recent variants. 🦠🧫
science.org/doi/10.1126/scit…
A thread ⬇️
Kevin John 🧪🧩 retweeted
New preprint by @alex_winnett @S_Tabachnikova et al.! We asked: which cellular immune signals control viral replication in the nose during the first days of SARS-CoV-2 infection — and how do they change with vaccination? With @ismagilovlab (1/)
medrxiv.org/content/10.64898…
Kevin John 🧪🧩 retweeted
Excited to share our paper just out: IgA is necessary and sufficient to prevent norovirus infection in mice | Science Translational Medicine science.org/doi/10.1126/scit…
Kevin John 🧪🧩 retweeted
This Australian video was made for awareness on the northern coast (a few years old), but it still very much applies to our southern coast bird flu (avian influenza, due to the A/H5N1 virus) infiltration.
Avoid! (sick animals)
Record!
Report! (phone 1800 675 888.)
1️⃣/2️⃣
Kevin John 🧪🧩 retweeted
Our latest preprint is out, where we investigated a profound SARS-CoV-2 epidemiological anomaly: BA.3.2.2 is selectively infecting children. Here, we show that the lack of ancestral-strain immune imprinting is promoting BA.3.2.2 pediatric infections.
1/9
biorxiv.org/content/10.64898…
Kevin John 🧪🧩 retweeted
Flu vaccination does more than protect against viruses circulating that year.
Our study published in #ScienceTranslationalMedicine showed 1994 vaccine generated broad immune responses against future H1N1 & FluB strains, but not H3N2, spanning 30 years. science.org/doi/10.1126/scit…
Kevin John 🧪🧩 retweeted
BREAKING🔔 Our new study is out at @biorxivpreprint. We established a novel animal model for SARS-CoV-2 infection using horseshoe bats, a natural reservoir of SARS-CoV-2-related coronaviruses in nature. Please repost🦇
biorxiv.org/content/10.64898…
Kevin John 🧪🧩 retweeted
So so excited to share @chris_cowley14, @LFSoto12 and my work finally out today in @ScienceMagazine! 🧵/10
science.org/eprint/TZBKR2RDB…
Kevin John 🧪🧩 retweeted
After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned
go.nature.com/47hykPQ
