Lab interested in gene regulation, embryonic development and evo-devo
Prague, Czech Republic
Joined November 2016
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Happy to share that our article "Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head" has just been published in Nature Communications rdcu.be/dWVEN
We show #neuralcrest-like and prechordal plate-like cells in amphioxus!
1/n Based on single-cell transcriptomics, signaling pathway manipulations, and cis-regulatory analysis we propose that some key innovations in vertebrate head development, such as the prechordal plate (PrCP) and neural crest (NC), can be traced back within the chordate lineage.
6/n Congratulations to Iryna for designing the study, performing numerous experiments, analyzing the scRNA-seq data, guiding the students involved, and ultimately bringing the entire project to completion!
7/n If you want to listen to AI-generated podcast that explains our paper in plain English:
notebooklm.google.com/notebo…
Just a comment on what AI got wrong: we have not shown actual NC-like cell migration (but we are working on it…)
From Fish to Mammals: Unraveling Brachyury Control in the Notochord by @aburger2009 & @KozmikLab, w/@EKFarley @MaxYunLab @AxelVisel @m_osterwalder @LiciaSelleri @FishEvoDevoGeno & teams is now out in nature.com/articles/s41467-0…
Wonderful collaboration. Happy to be part of it!
Congrats to a former PhD student of @KozmikLab and alumnus of @imgprague Peter Fabian for receiving the prestigious #ERCStG. Well deserved! You are such a great person. Smart recruitment by @MUNI_Science and great boost for Czech DevBio community. Go Peto, go... @Fabian_Lab
Zbynek Kozmik retweeted
Extraordinary claims require extraordinary evidence. In our new @Nature paper, Darrin Schultz @conchoecia used the position of genes on chromosomes to show that ctenophores (comb jellies) not sponges are the sister-group to all other animals. nature.com/articles/s41586-0…
ALT Dan Rokhsar and Darrin wrote most of the first draft of the text, and Oleg Simakov and Dan laid the foundation for looking at these conserved blocks with their work on Ancestral Linkage Groups (ALGs). Darrin and I explored ways to visualize and interpret the results.
Zbynek Kozmik retweeted
For 100s of years, sponges were assumed to have split first. In 2008 a transcriptome-based study led by @caseywdunn suggested ctenophores were sister to other Metazoa. The debate has bounced back and forth, ever since, even with more genomes sequenced.
ALT Sometimes papers arguing opposite viewpoints would appear in the same journal a month apart!
Zbynek Kozmik retweeted
If you don't get it, you don't get it
Download our (updated) massive database of POSTDOC fellowships.
We list 373 fellowships w/ description, $ amount, deadline, and eligibility criteria (e.g. citizenship).
HERE: research.jhu.edu/rdt/funding…
I am so proud! Big congratulations to a former PhD student of @KozmikLab and alumnus of @imgprague Peter Fabian.
Congratulations to the IZFS 2023 Chi-Bin Chien Award winner, Dr. Peter Fabian! The award recognizes early career investigators who have made significant contributions to zebrafish research and will be presented at the #EZM2023 meeting on July 9-13, 2023 izfs.org/news/congratulation…
Seeing humans through an evolutionary lens science.org/doi/10.1126/scie…
Zbynek Kozmik retweeted
Hooray, it’s #FluorescenceFriday! And we are admiring the beautiful work of Cassie Kemmler, @chrmosimann @aburger2009 @blockintheback @kwantourage & colleagues. They share their next-generation plasmids for transgenesis in zebrafish and more!
@Dev_journal: journals.biologists.com/dev/…
ALT Zebrafish labelled with mCerulean, a versatile blue fluorophore, from Kemmler, et al.
Zbynek Kozmik retweeted
Happy to share our TOGA manuscript, now out in Science. Project started 6 years ago, we and others already used TOGA in numerous projects. TOGA integrates gene annotation and orthology inference, and scales to hundreds of genomes. science.org/doi/10.1126/scie…
Zbynek Kozmik retweeted
The @ZoonomiaProject’s sequencing of more than 240 mammal genomes is paving new roads for understanding mammalian diversity and evolution and ourselves.
Learn more in a new special issue of Science: scim.ag/2oO #Zoonomia
Our 2nd exciting joint project with the power duo @chrmosimann & @aburger2009 is now at biorxiv.org/content/10.1101/…
Last time @KozmikLab made transgenic #amphioxus for nature.com/articles/s41467-0…, this time we made a triple enhancer KO in mice. That’s what I call lab flexibility.
Zbynek Kozmik retweeted
Chromatin 🤝EvoDevo and explains how skates evolved their wings 🧚
I am so thrilled about the publication of our little skate paper, a big collaborative effort with @tetsuyanakamu @Dariloops @rdacemel @jjtenagu @DanRokhsar and the late @jlgomska ⬇️
nature.com/articles/s41586-0…
