@LabYaffe

The Yaffe Lab at the @kochinstitute, @MITBiology, and @MITdeptofBE | Interested in kinase signaling and precision medicine | Account is run by lab trainees

 Cambridge, MA
yaffelab.mit.edu/
Joined August 2020
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  • Following65
  • Followers400
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New pre-print from the lab! Fanconi anemia proteins not only repair DNA interstrand crosslinks, but also DNA double-strand breaks. Great work by @BertKooij, Fenna van der Wal, in collaboration with @marcelvanvugt, @altmeyerlab and @LabYaffe! biorxiv.org/content/10.1101/…

The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombi...

Homologous Recombination (HR) is a high-fidelity repair mechanism of DNA Double-Strand Breaks (DSBs), which are induced by irradiation, genotoxic chemicals or physiological DNA damaging processes....

biorxiv.org
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Yaffe Lab find timing and dosage of DNA-damaging drugs are key to whether a cancer cell dies or enters senescence. news.mit.edu/2023/making-sen… @mbyaffe @CellSystemsCP @scientist_tati
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Yaffe Lab researchers find that timing and dosage of DNA-damaging drugs are key to cell fate. The @CellSystemsCP study has implications for how a class of cancer drugs called MEK inhibitors are used in combination with chemotherapy. news.mit.edu/2023/making-sen…

Making sense of cell fate

The timing and dosage of DNA-damaging drugs determine whether cancer cells die or enter senescence, according to a study from the MIT Koch Institute lab of Michael Yaffe. The work suggests clinical...

news.mit.edu
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authors.elsevier.com/c/1hRk6…
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Excited to share our latest story - JNK and Erk MAPK signaling controls senescence from damaged replication forks, and at later times drives the SASP. Means MEK inhibitors with topoisomerase chemo likely to be a bad combo!
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Fantastic motifs and signaling meeting at EMBL the last 2 days in honor of Toby Gibson.
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It's like the universe wants me to revisit that groundbreaking editorial article from @LabYaffe: pubmed.ncbi.nlm.nih.gov/3067… 3/3

Why geneticists stole cancer research even though cancer is primarily a signaling disease - PubMed

Genetic approaches to cancer research have dramatically advanced our understanding of the pathophysiology of this disease, leading to similar genetics-based approaches for precision therapy, which...

pubmed.ncbi.nlm.nih.gov
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Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3. frontiersin.org/articles/10.…

Frontiers | MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins...

14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cel...

frontiersin.org
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Very happy to share Brian and Ingred's latest work in the lab identifying two unique subclasses of neutrophils that arise after tissue injury. Neutrophils in trauma and cancer are getting more and more complex! Contribute to local DNA Damage for sure! journals.lww.com/jtrauma/Abs…

Neutrophil heterogeneity and emergence of a... : Journal of Trauma and Acute Care Surgery

INTRODUCTIONMultiple large clinical trauma trials have documented an increased susceptibility to infection after injury. Although neutrophils...

ovid.com
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Can trauma influence #neutrophil heterogeneity in circulating blood leukocytes? A study in human trauma patients shows that two unique neutrophil populations emerge after trauma which may have immunosuppressive properties #JoTACS @LabYaffe @mbyaffe @MIT journals.lww.com/jtrauma/Ful…
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Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill #CancerCells of Disparate Origins Independently of Androgen Receptor Signaling, by @LabYaffe et al. bit.ly/3HXCJuZ @MIT
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Really proud of staff scientist Jesse Patterson and the folks in the lab for our latest Plk1 mitosis and DNA damage paper, a great collaboration with the Balk, Isaac’s, and Jonas labs and our colleagues at Cardiff Oncology! Cover image from Jesse!
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Researchers now have access to vast troves of scientific data and analytical tools, but @hholdenthorp and @mbyaffe stress that #BasicResearch remains a fundamental priority for scientific progress, biological insight, and @SciSignal.  Read the Editorial: scim.ag/187
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We are delighted to share our work, now available in @Nature: nature.com/articles/s41586-0… Our scoring system can be accessed here: kinase-library.phosphosite.o… Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features! #TheKinaseLibrary #KL

An atlas of substrate specificities for the human serine/threonine kinome

Nature - Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by...

nature.com
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Truly excited that our collaboration with @CantleyLab and @LabYaffe, led by the mighty Jared Johnson and the unstoppable @Tomer_M_Yaron, to map substrate motifs for the Ser/Thr kinome is now out! Literally a project that spanned decades. nature.com/articles/s41586-0…
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Dr. @mbyaffe out of @MITBiology led a study that reported that onvansertib and #abiraterone combination enhanced mitotic arrest and inhibited tumor cell growth compared to either agent alone in a xenograft model of #ProstateCancer. @CR_AACR @LabYaffe 📑 bit.ly/3Vhv12u
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View the visual abstract for "The Evolution of Neutrophil Heterogeneity and Emergence of a Distinct Population of Low Density Neutrophils after Human Trauma" by @mbyaffe @LabYaffe #AAST2022 #SurgTwitter #MedEd #SoMe4Surgery #MedTwitter #MedStudent
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🎯Journal of Translational Genetics and Genomics interviewed Dr. Fred C. Lam from Saint Elizabeth's Medical Center. 🥳It is our honor to have an academic exchange and it was a great experience. 🌟More details: jtggjournal.com/announcement…
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Excited to share our latest work on DNA double strand break repair from Bert van de Kooij and Alex Kruswick in collaboration with Haico van Attikum. @LabYaffe nature.com/articles/s41467-0…

Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing...

Nature Communications - Correct repair of broken DNA molecules is required to prevent potentially oncogenic mutations. To study repair fidelity and mechanism, van de Kooij et al. developed single...

nature.com
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Key takeaways: never ever give up, get to know yourself, let your clinical interests drive your science, you see what you look for, and don’t ignore life outside of the lab – at Arizona, USA
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