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Thrilled to share our new paper in @CellStemCell, where we turn programmed cell death into a tool for building better tissues. (1/8): cell.com/cell-stem-cell/full…
Mohammad Taheri retweeted
1/10 What if building tissues requires not only adding the right cells, materials or ECMs, but removing the wrong ones too? (free link at 10/10)
#Development builds through both construction and elimination. Yet tissue engineering largely focuses on addition. We do not have a #subtractive framework in our synthetic in. whereas tissues operate far from the constraints exist in vivo.
Our new @CellStemCell paper explores the missing half: "Subtractive Tissue Engineering" is how we named it. #development #celldeath #syntheticbiology #systemsbiology #embryogenesis #organoids #NAMs #human #stemcells🧵
ALT Programmable subtraction for tissue engineering
In embryoids, apoptosis restricted to cells occupying the prospective lumen enhanced cavitation. (7/8)
Thanks to @MoEbrahimkhani and @samira_kiani1 for their guidance and mentorship, @xiang_1905 for three years of relentless work on this, @MokhtariTahere for her instrumental help with constructing the genetic circuits, and the rest of our coauthors. (8/8)
Mohammad Taheri retweeted
it's a pleasure to share our lab preprint on “Modelling Human Post-Implantation Development via
Extra-Embryonic Niche Engineering” ! It is timely considering recent works reported from labs of @MZG_Lab @jacob_hanna @ISSCR #ISSCR2023. See below. I hope you will enjoy the work!
Mohammad Taheri retweeted
It is my pleasure to present the preprint for my graduate research in the @MoEbrahimkhani lab until this point, out now in biorxiv, modelling the human bilaminar disc through gastrulation and beyond!
biorxiv.org/content/10.1101/…
