Anti-aging Enthusiast📚| Synthetic Biologist👩🏻🔬| Genetic Engineer🧬👩🏻💻| Dreamer, believer, doer
Pittsburgh, PA
Joined January 2020
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🚀 Breaking News! 🚀 Thrilled to announce that my 1st-author manuscript is now available online!🧬💉
Key innovations in our study:
🔬 1) First demonstration of mRNA-based repressors for epigenetic editing of an essential immune signaling gene previously considered undruggable
Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control biorxiv.org/content/10.1101/… #biorxiv_immuno
Tahere Mokhtari retweeted
1/10 What if building tissues requires not only adding the right cells, materials or ECMs, but removing the wrong ones too? (free link at 10/10)
#Development builds through both construction and elimination. Yet tissue engineering largely focuses on addition. We do not have a #subtractive framework in our synthetic in. whereas tissues operate far from the constraints exist in vivo.
Our new @CellStemCell paper explores the missing half: "Subtractive Tissue Engineering" is how we named it. #development #celldeath #syntheticbiology #systemsbiology #embryogenesis #organoids #NAMs #human #stemcells🧵
ALT Programmable subtraction for tissue engineering
Tahere Mokhtari retweeted
Thrilled to share our new paper in @CellStemCell, where we turn programmed cell death into a tool for building better tissues. (1/8): cell.com/cell-stem-cell/full…
Immense gratitude to my wonderful advisor Dr. @samira_kiani1, collaborators, mentors, and the dedicated lab members who contributed to this project over the years. This achievement wouldn't have been possible without your brilliance and persistence!
🔄 4) Successful demonstration of our approach in two critical applications: reducing inflammation in septicemia models and improving viral vector re-administration
This work represents a step forward for developing more precise immunomodulatory therapies.
💊 2) Exploiting lipid nanoparticle delivery system that efficiently targets immune cells in spleen and liver
🛡️ 3) Introduction of "reverse-vaccination" strategy using mRNA-based therapeutics that could overcome pre-existing immunity challenges in gene therapy
Tahere Mokhtari retweeted
qPCR can measure expression of virtually any gene... in homogenized tissues. Here, we show an "in-vivo qPCR" equivalent, where we measure a sequence-specific transcript with synthetic serum markers and enzyme-based signal amplification.
biorxiv.org/content/10.1101/…
Tahere Mokhtari retweeted
MDL-800, a chemical activator the NAD+-dependent enzyme SIRT6, which is linked to mouse & human longevity, increases the degradation of toxic amyloid precursor protein (APP) & delays dementia in Alzheimer’s model mice 🐁🧠💪
science.org/doi/10.1126/scis…
Tahere Mokhtari retweeted
Science is the belief in the ignorance of experts. Never accept an idea just because someone with a title says it’s true.
Tahere Mokhtari retweeted
A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phillips @HernanGGarcia. 20 years later we can measure them: nature.com/articles/s41586-0… Thank you @WJGreenleaf @bgrdoughty @MichaelaThinks Julia and all co-authors!
Tahere Mokhtari retweeted
My lab’s new paper using chromosome engineering to correct a complex chromosomal rearrangement is now up on @biorxivpreprint!
biorxiv.org/content/10.1101/…
Tahere Mokhtari retweeted
New @Nature
A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells
nature.com/articles/s41586-0…
@vonMeyenn @laurahinte
Tahere Mokhtari retweeted
Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates
Read this #OpenAccess Research Article by @DinaRekler, Shai Ofek, Sarah Kagan, Gilgi Friedlander & @ChayaKalcheim @HebrewU:
journals.biologists.com/dev/…
ALT Figure 1: Assignment of transcriptomes to cell identities. (A) Experimental design for isolating single dorsal NT cells. (B,C) NTs electroporated at E2.5 and microdissected at E4, showing similar Msx1-Citrine labeling between control and RARα403 treatments. (D) UMAP of control and treated samples, colored by cluster with cell count indicated
Tahere Mokhtari retweeted
Survivor of rare rapid-ageing disease progeria dies at 28 | Reuters reuters.com/world/europe/sur…
Tahere Mokhtari retweeted
Sammy Basso @SammyBasso, one of the most remarkable people to share our world, passed away last night from complications associated with progeria, the ultra-rare ‘rapid aging’ genetic disease Sammy both suffered from and transcended.
Sammy realized that a base editing treatment that corrects the root cause of progeria and rescues animals with the disease would likely not be ready in time for him, but worked tirelessly every day to bring this potential treatment to other patients so they might have a better life.
Sammy made the most of every day, living with great purpose, intention, and joy that was inspiring, infectious, and reminded us of what’s truly important.
We miss him terribly. 😔
xitter.cf/davidrliu/status/16807…
reuters.com/world/europe/sur…
Tahere Mokhtari retweeted
First atlas of nasal/oral microbes during aging. Before the ages of 15-24, youths have fewer species than older people & microbe types are influenced by smoking, infections, antibiotics & living with children. Your mouth is more important than you think. Here's why... 👶🏼🧵@CellCellPress shorturl.at/mMCIP
Tahere Mokhtari retweeted
Restricting calories by 12% significantly slows the rate of human aging 🥗⏰ 🧵 nature.com/articles/s43587-0…
Tahere Mokhtari retweeted
Your body has its own renewal system. We call it sleep, and the more you learn to respect it, by giving it 7-8 hours to do its thing every night, the slower your aging clock will tick, both physically and mentally
Tahere Mokhtari retweeted
Sleep is your #1 life priority. Fight for it as hard as anything else you do in life.
