🚨 New PECARN Study Alert! 🚨 The PECARN STArT trial asked an important question: Could IV arginine help children and young adults with sickle cell disease recover faster from acute pain episodes? jamanetwork.com/journals/jam… #SPARC #PECARN #SickleCellDisease

"The jury is still out for treatment with arginine therapy." — Dr. @claudiarmorris1 The #PECARN STArT trial — a double-blind RCT testing IV arginine for sickle cell pain crises in children and young adults — was stopped early after an interim analysis suggested the primary endpoint was unlikely to be met. But Dr. Morris isn't ready to close the book on the drug. Here's why 👇 🔗 hcplive.com/view/pecarn-star… #SPARC #PECARN #PediatricEmergencyMedicine #EmergencyMedicine #SickleCell

#NewBlogPost Most sepsis screening tools identify kids who already have sepsis, or who are already suspected of infection. That's useful — but it's not early enough. This @PECARN model predicts who will develop sepsis in the next 48 hours, across the general ED population, before clinical suspicion even forms. Earlier signal ➡️ earlier intervention ➡️ better outcomes. The biology hasn't changed. The tooling has. @JBelferMD @ERAlpernMD @FranBalamuth pecarn.org/pecarn_news/one-s… #PRIME #PEMNEWS #PediatricEmergencyMedicine #Pediatric #EmergencyMedicine #SEPSIS

Same disease. Same pain crisis. Same type of hospital. One child goes home in 28 hours. Another stays nearly 6 days. A new secondary analysis from the #PECARN STArT trial — the largest pediatric sickle cell pain crisis trial enrollment to date — found that *where* a child receives care may matter as much as *how sick they are*. The findings are worth a close read. 🔗 pecarn.org/pecarn_news/same-… #SPARC #PediatricEmergencyMedicine #Pediatric #SickleCell

🚨New #PECARN Blog Post 🚨 Check out the latest blog, "The End of Routine Lumbar Punctures for the Febrile Infant 28 Days and Younger" @M_Lin walks through a recent #PECARN study to share the changing landscape of lumbar punctures for young infants Read it here 👉🏼 pecarn.org/pecarn_news/the-e… #PRIME #EmergencyMedicine #Pediatrics #FebrileInfant @JAMA_current