@MercerLab

Pox Virologist and Systems Biologist, Virus Cell Biology Lab, @IMIBirmingham @UoBbiosciences

 Birmingham, England
birmingham.ac.uk/staff/profiles/biosciences/mercer-jason.aspx
Joined October 2016
  • Tweets2.6K
  • Following1.8K
  • Followers2.1K
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Replying to @MahadiFX0
Ahhhh, the good old days of bare knuckle boxing in high school gym class 😅
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Jason Mercer retweeted
Melanie Krause@m_krause0206May 18
This points to a direct, regulated interaction between viral proteins and the host lipidation machinery. Thank you to co-authors @ayakimovich, @MercerLab and Ingo Drexler
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Replying to @DeChristianLife
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🔥 Open postdoc position in human inflammation-driven control of infection! Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! Please RT (1/5)
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Congratulations to @m_krause0206 for her paper just out in @JCellBiol! See her twittorial below and thanks to all the great collaborations 🙏
Melanie Krause@m_krause02066 May 2024
The main story of my PhD research project is finally out in @JCellBiol today! rupress.org/jcb/article/223/… We were looking at how Vaccinia virus circumvents host immunity by disabling the autophagy machinery through depletion of sequestome-like receptors (SLRs). For a 🧵see below:
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Jason Mercer retweeted
Ian White@EM__Ian28 Mar 2024
Paper out with former @LMCB_UCL colleagues @SamolejJ and @MercerLab Cardiac glycosides inhibit early and late vaccinia virus protein expression - go.shr.lc/3J1e2NC
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And another one for @SamolejJ! Here he shows how cardiac glycosides (think toad venom) inhibit poxvirus infection. Just out in JGV @MicrobioSoc microbiologyresearch.org/con… Great working with @StrangVirusLab and @EM__Ian once again!!

Cardiac glycosides inhibit early and late vaccinia virus protein expression

microbiologyresearch.org
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Bisbenzimide compounds inhibit replication of prototype and pandemic potential poxviruses! @SamolejJ has extended our understanding of these novel poxvirus inhibitors @StrangVirusLab @MercerLab @ayakimovich mpox work by @cvr_crush journals.asm.org/doi/10.1128…
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Congratulations to @SamolejJ who shows that bisbenzimides block replication of prototype (vaccinia) and pandemic potential (mpox) poxviruses! Just out in @JournalSpectrum journals.asm.org/doi/10.1128… Excellent collaboration with @StrangVirusLab @CVRinfo @lifearc1 and @ayakimovich

Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses |...

The 2022 mpox (monkeypox) outbreak served as a stark reminder that due to the cessation of smallpox vaccination over 40 years ago, most of the human population remains susceptible to poxvirus...

journals.asm.org
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Really happy to see this work out and peer reviewed. Thanks a lot to everyone involved. Here is a happy bleb to entice you into reading our deep dive into vaccinia virus binding!
Jason Mercer@MercerLab8 Feb 2024
Congratulations to @laurapokorny who shows that virus binding proteins aren’t just for binding! Just out in @emboreports Thanks to all who contributed! @JemimaBurden @yorgomodis @D4V1D_4 Becky Bamford,Kendra Leigh,Pooja Sridhar,Timothy Knowles embopress.org/doi/full/10.10…

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

EMBO Reports - Cellular attachment of viruses determines their cell tropism and species specificity. For entry, vaccinia, the prototypic poxvirus, relies on four binding proteins and an...

link.springer.com
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Congratulations to @laurapokorny who shows that virus binding proteins aren’t just for binding! Just out in @emboreports Thanks to all who contributed! @JemimaBurden @yorgomodis @D4V1D_4 Becky Bamford,Kendra Leigh,Pooja Sridhar,Timothy Knowles embopress.org/doi/full/10.10…

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

EMBO Reports - Cellular attachment of viruses determines their cell tropism and species specificity. For entry, vaccinia, the prototypic poxvirus, relies on four binding proteins and an...

link.springer.com
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Today we opened the wonderful play ship for the @HanburySchool children in Leo’s memory. 💚 All made possible by resources, work and enthusiasm of our friends, community and the school. 😍 We are grateful Leo’s ship will bring years of fun to the kids. 🙏
HanburyCofEFirst@HanburySchool21 Dec 2023
Children at Hanbury C of E First School celebrated the launch of a spectacular new play area, built to celebrate the life of one of their beloved classmates. HFS Leo was “launched” today by Leo Mercer’s family. hanbury.eschools.co.uk/web/p…
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💥 Out now @ScienceMagazine. @DanielHFisch solves the mystery of bystander cell protection during infection. An exciting mechanism, cells are so smart! PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection | Science science.org/doi/full/10.1126…
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