@MolCytogenLab

Basically, Science is everywhere

Joined August 2019
  • Tweets476
  • Following416
  • Followers223
10Media
Rodriguez-Perales Lab retweeted
Pedro García-Gómez@pedgargmSep 29
What do cancer cells they first arrive in the brain? Surprisingly, they seem to hit the pause button. Check out how micrometastasis behave and how to target them in our recent paper in Cancer cell. I never expected a “pause” to keep us this busy… cell.com/cancer-cell/fulltex…

A transient MXD4-dependent proliferative pause enables survival of brain micrometastases

García-Gómez et al. identify a transient state, termed the proliferative pause, that enables the survival of micrometastases during vascular co-option by buffering organ-imposed stress. Targeting...

cell.com
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Rodriguez-Perales Lab retweeted
Andrea Ventura@aventura71Sep 25
Very nice paper from Agnel Sfeir's group and colleagues on the role of MMEJ in ecDNA maintenance and rearrangements. nature.com/articles/s41586-0…

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

Nature - Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggesting that Polθ...

nature.com
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Daniel Bauer@danielevanbauerSep 16
Inspired by Gibson cloning, we describe prime assembly, now published, for in cellulo targeted integration of gene-sized DNA fragments using prime editing. nature.com/articles/s41586-0…

Targeted genomic integration and rearrangement using prime assembly

Nature - Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding,...

nature.com
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🚨 #JobOffer 🧬 Our Genomics Platform is seeking for a #LaboratoryTechnician in Training! 📅 Apply until 31 August 👇 careers.carrerasresearch.org…
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Rodriguez-Perales Lab retweeted
Carolina Grandellis@cgrandellisJun 8
science.org/doi/10.1126/scia…

PlasmidGPT: A generative framework for plasmid analysis and generation

A generative framework predicts plasmid features and enables controlled generation of functional DNA sequences.

science.org
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Nature Methods@naturemethodsJun 2
High multiplicity of infection sgRNA multiplexing maintains CRISPRi screen performance while enabling reduced cell numbers. nature.com/articles/s41592-0…
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Rodriguez-Perales Lab retweeted
Peter Ly@PeterLyLabMay 19
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7) cell.com/cell/fulltext/S0092…
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David R. Liu
@davidrliuMay 20
Today in @NatBiotech, we report the directed evolution of structured RNA motifs that enhance the efficiency of prime editing. Iterated high-throughput pooled screens and mutagenesis of these small RNA elements improved transient pegRNA lifetime. drive.google.com/file/d/1Nyt… 1/11
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Rodriguez-Perales Lab retweeted
Patrick Hsu
@pdhsuMay 21
Thrilled to share I've started at @Stanford's Department of Pathology (@StanfordPath) in addition to @ArcInstitute. Looking forward to a shorter commute after 5 years at @BerkeleyBioE and embarking on daring new projects We're recruiting multiple postdocs and technical staff👇
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Ｊｕｎ　Ｙａｓｕｄａ@jyasuda1May 15
細胞内で免疫反応を抑制した長鎖DNAを使って、大規模なゲノム編集を可能にしたという論文。Nature。 nature.com/articles/s41586-0…

Immune evasive DNA donors and recombinases license kilobase-scale writing

Nature - INSTALL overcomes fundamental challenges for DNA delivery and integration methods by synergizing immune-stealth nucleic acids with recombinases to enable kilobase-scale integration...

nature.com
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Rodriguez-Perales Lab retweeted
Nate Krah
@N8KrahMay 6
🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵
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Rodriguez-Perales Lab retweeted
ElowitzLab
@ElowitzLabApr 25
Just out: our forward-looking essay on mRNA “delivery cells”—engineered cells that could locally manufacture mRNA at disease sites within the body and transfer it to target cells in extracellular vesicles.
Nature Reviews Bioengineering@natrevbioengApr 24
Engineered cells as programmable mRNA delivery vehicles dlvr.it/TSBzt7
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Rodriguez-Perales Lab retweeted
Takashi Akera@TakashiAkeraLabMar 22
🚨Please repost!! 🧬We are hiring POSTDOC now!! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬
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GENYO@genyo_ptsFeb 20
🥼Junior Group Leader required to lead a new group in areas such as human genomics, cancer, aging, and advanced therapies. ℹ️Full requirements and details in the call for applications: fibao.es/ofertas/ficha/1378/ #ResearchJobs #JuniorGroupLeader #ScienceCareers #Granada
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CIEMAT
@CIEMAT_OPIFeb 5
🧬 Un equipo del @BioInn_CIEMAT y del @CNIOStopCancer ha utilizado #CRISPR para eliminar células tumorales con oncogenes amplificados, sin dañar las sanas. Los resultados son prometedores en modelos de neuroblastoma, cáncer de pulmón y colorrectal. Te lo contamos todo aquí: ciemat.es/w/una-nueva-estrat… #CIEMAT #Investigación #EdiciónGénica #Cáncer #Investigación
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Thrilled to share that our latest paper is out! We present a new experimental CRISPR-based strategy to target tumors with amplified oncogenes. Turning gene amplification into a vulnerability to selectively induce lethal DNA damage in cancer cells.
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In preclinical models of neuroblastoma, SCLC, and colorectal cancer, we observe reduced tumor growth, improved survival, and signs of ICD. Link:link.springer.com/article/10… @CNIOStopCancer @BioInn_CIEMAT @SpringerNature @BioMedCentral

Selective genome editing of amplified oncogenes triggers immunogenic cell death and tumor remodeling

Molecular Cancer - Oncogene amplifications fuel some of the most lethal, therapy‑refractory cancers, yet remain clinically untargeted. We report a single‑guide CRISPR/Cas9 strategy that...

link.springer.com
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Huge thanks for the support: @ContraCancerEs @FEDER @SaludISCIII
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Rodriguez-Perales Lab retweeted
David Sun Kong, Ph.D.@davidsunkongJan 5
I’m excited to announce that the application for the 2026 edition of our @medialab and global synthetic biology course “How to Grow (Almost) Anything” is now open! Application link in thread 👇
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Rodriguez-Perales Lab retweeted
TERAV@red_terav29 Oct 2025
Oferta de empleo en el Pediatric Cancer Center del Hospital SJD de Barcelona, para liderar y gestionar la recién establecida Unidad de Citometría. Especialista en Citómica, infórmate en: hospitalsantjoandedeu.talent…
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