@OpenWorm

OpenWorm is an open science project dedicated to creating the first digital organism, a C. elegans nematode. Get involved at http://t.co/N48aVJoGna

openworm.org/
Joined December 2010
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In 1986, John White published "The Mind of a Worm," the first complete wiring diagram of any animal's brain. 7,000+ synapses, mapped by hand. This year, he was awarded the @WileyGlobal Prize in Biomedical Sciences. He's donating his share to @OpenWorm.
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We're organizing 2026 around: 29 Design Documents specifying how to model C. elegans, under scientific review A contributor progression model (Observer to Maintainer) AI-assisted contribution pathways The science is human-led. The scaling is AI-augmented.
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This is the largest single donation in OpenWorm's history. We won't waste it. Full announcement + 2026 plans: openworm.tumblr.com/post/815…
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Bravo @eboyden3 and @koerding ! thetransmitter.org/computati…

Whole-brain, bottom-up neuroscience: The time for it is now

Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate…

thetransmitter.org
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Interested in doing post-doctoral work with OpenWorm? Check out this opportunity in the UK! ucl.ac.uk/work-at-ucl/search…

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

ucl.ac.uk
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Now streaming: OpenWorm interview on the @DataSkeptic podcast open.spotify.com/episode/4Re…

OpenWorm

Data Skeptic · Episode

open.spotify.com
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A major obstacle to modeling the nervous system of the worm has been the unknown weights of the connections. Which are excitatory or inhibitory and how strong? Well, the lab of @AndrewLeifer has put out a Neural Signal propagation atlas to address this critical gap (1/4)
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Their preprint is online here: arxiv.org/abs/2208.04790 and you can explore the data set via an online browser here: funconn.princeton.edu/ and a basic simulator based on these data here: funsim.princeton.edu/ (3/4)

Neural signal propagation atlas of C. elegans

A fundamental problem in neuroscience is understanding how a network's properties dictate its function. Connectomics provides one avenue to predict nervous system function. To test this...

arxiv.org
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Bravo to all the authors! (4/4)
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Fun to interactively play on the @OpenWorm site with our best mapped nervous system yet, and to think about building a virtual organism: opensourcebrain.org/projects…
Max Tegmark
@tegmark1 Jun 2022
Excited about the publication of our state-of-the-art 3D neuron atlas of #Celegans, the world's cutest worm. It's crazy how much smarts it gets from just 302 neurons! bmcbioinformatics.biomedcent…

Toward a more accurate 3D atlas of C. elegans neurons

BMC Bioinformatics - Determining cell identity in volumetric images of tagged neuronal nuclei is an ongoing challenge in contemporary neuroscience. Frequently, cell identity is determined by...

link.springer.com
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Promising resource from the Flavell lab with freely moving whole-brain calcium imaging datasets: wormwideweb.org/
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Omg @YeminiLab. The White Knight of neuron identification. As designated by Keynote Speaker Oliver Hobert. And well deserved moniker too. Go NeuroPAL! #Worm23
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How friendly is worm community? We converged on finding w Cohen and Emmons lab. Papers came out together (below). Started Glasgow #Worm23 w stimulating discussions over haggis pizza w Netta Cohen to discuss collaborations 1) nature.com/articles/s41586-0… 2) nature.com/articles/s41586-0…

A multi-scale brain map derived from whole-brain volumetric reconstructions

Nature - Two complete volumetric reconstructions of the Caenorhabditis elegans main neuropil (the nerve ring) reveal multi-scale spatial organization that supports both conserved and variable...

nature.com
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All winning entries of the #wormart at #Worm23 @GeneticsGSA. Wait until the end for a QR code for all entries. @foodskop started Art show in 1997. Do tag the winners/participants & RT. @chud8 @VarshaS53228024 @wormsense
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#Serotonin is a common but complex target of psychiatric drugs. A new study by the @MIT lab of Steven Flavell provides a deep but also brain-wide look at its role in producing behavior in C. elegans. picower.mit.edu/news/molecul… @ScienceMIT @mitbrainandcog #neuroscience

From molecular to whole-brain scale in a simple animal, study reveals serotonin’s effects

With full genetic control and visibility into neural activity and behavior, MIT scientists map out chemical’s role in behavior

picower.mit.edu
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A long shot, but are any of the authors on the RF diffusion paper following me, and would be willing to chat?
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