The NIH-funded Polygenic Risk Methods Development (PRIMED) Consortium
Joined September 2021
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PRIMED Year in Review: Join us as we look back on some of what @PRSmethods consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/
👀 ICYMI - compilation of @PRSmethods work being presented at #ASHG26 in Montreal this week
Headed to #ASHG26 in Montreal next week? Mark your conference calendar with these abstracts from @PRSmethods consortium members docs.google.com/spreadsheets…
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Headed to #ASHG26 in Montreal next week? Mark your conference calendar with these abstracts from @PRSmethods consortium members docs.google.com/spreadsheets…
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These talks and posters illustrate how @PRSmethods is working to improve genetic risk prediction across populations by building new computational tools, pooling data across biobanks, and incorporating factors like genetic ancestry, age, and social context 🧬🌎🌍🌏
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🧬 👀 In addition to innovating methods for genetic risk prediction across different contexts, the @PRSmethods consortium is proactively considering ethical and social implications of its work
🎬 See our video collection:
primedconsortium.org/educati…
Check out Coordinating Center member Stephanie Gogarten presenting at @ELSIhub ELSI Congress on "Sensitive sociobehavioral traits in the construction of ensemble Polygenic Risk Score models"
vimeo.com/1206496440?fl=pl&f…
🎬 New Friday video drop!
Watch @PRSmethods investigator Micah Hysong present on "Practical considerations for social determinant-based disease prediction," using the @AllofUsResearch data
primedconsortium.org/educati…
PRIMED Consortium retweeted
Registration is open for Polygenic Risk Scores 2026.
Sponsors: Med College of Wisconsin and UW-Madison
Focus: What does it take to implement PRS in clinical practice?
Sept 10 | Brookfield, WI; Speakers across medicine, lab science, informatics, and law.
registration.socio.events/e/…
The NIH-funded PRIMED (Polygenic Risk Methods Development) Consortium was launched in 2021 and is working to address gaps noted in this recent @nytimes article
nytimes.com/2026/07/20/scien…
🔖 Read about our Research Highlights primedconsortium.org/researc…
📽️ Watch PRIMED investigators in our Video Collection primedconsortium.org/educati…
✅ Follow us at @PRSmethods
Watch @PRSmethods investigators Dave Conti and Sara Cromer present on "Incorporating Polygenic Risk Scores and Social Determinants of Health Across Populations" from the May @AJHGNews, now added to our PRIMED video collection: primedconsortium.org/educati…
Congrats to @Yunfeng_Ruan and colleagues on this work which, incidentally, was part of why she won the @PRSmethods consortium award for "Most Creative Software Package Names" 🎉
Our study led by @Yunfeng_Ruan describes a method of interpolated polygenic risk scoring (DiscoDivas) for more accurate scoring across ancestries, particularly in settings of admixture sciencedirect.com/science/ar… @AJHGNews
@AniruddhPatelMD @skoyamamd @buutrg @somijemmacho @HornsbyWhitney @AndrewHaoyu @nilanjan10c
Join @PRSmethods investigators on May 13 to discuss integrating Social Determinants of Health (SDoH) and polygenic risk scores
🗓️Event information: bit.ly/4chGKtr
🔖Publication: pubmed.ncbi.nlm.nih.gov/4178…
The authors take the mic.
In this upcoming May 13 Journal Club Webinar,
@AJHGNews paper authors @sjcromermd, MD, MS, and David Conti, PhD, unpack what it takes to integrate PRS and SDoH across genetically and socially varied populations—LIVE: learning.ashg.org/products/i…
#ASHG
ALT Sara J Cromer, MD, MS
ALT David Conti, PhD
PRIMED Consortium retweeted
Very excited to share our study spearheaded by A. Misra & @AniruddhPatelMD describing the development & validation of our clinical multi-CVD polygenic risk score test, including how it might inform CVD prevention sciencedirect.com/science/ar… @JACCJournals
Any clinician can order this @MassGenBrigham @broadinstitute test today: massgeneralbrigham.org/en/re…
We used an integrated framework we previously developed and described to maximize performance and score stability, and allow for versioning as genomic interpretation continually improves.
cell.com/cell-genomics/fullt…
nature.com/articles/s41467-0…
The score was optimized in the nationwide @NIH @AllofUsResearch Program to enhance generalizability across communities, with validation in the @MassGenBrigham Biobank
@amandajowell @buutrg @aklfahed @shaan_khurshid @patrick_ellinor @nialljlennon @HornsbyWhitney @EWkarlson
👀🧬🫀ICYMI - updated data release from the @ourhealthstudy of cardiovascular disease in South Asians now available on @useAnVIL!
anvilproject.org/news/2025/1…
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Funding for BGE sequencing and analyses are provided through the NIH-funded @PRSmethods consortium
For more information and how to apply for access, visit primedconsortium.org/researc…
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🔖 Also check out the @ourhealthstudy design recently published in @npjDigitalMed nature.com/articles/s41746-0…
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PRIMED Consortium retweeted
📷📷 We’re excited to share that the OurHealth study is featured in @npjDigitalMed! Swipe to learn more about our study’s design and read the full article here: nature.com/articles/s41746-0… . #OurHealth #hearthealth #research #southasian #cardiovascularhealth
PRIMED Consortium retweeted
eMERGE returned PRS/Fam Hx/Mono results to n=23,840, 35% hi-risk for ≥1 of 11 diseases. Note: 1) high burden of genetic risk for common disease; 2) large-scale genomic risk assessment is feasible; 3) equity challenges must be addressed for implementation doi.org/10.1016/j.ajhg.2026.…
🎉🧬👀 New work out from Cromer et al. in the @PRSmethods consortium Social Determinants of Health Working Group, on how to model social and structural determinants of health jointly with genetic risk
🧬 New Review from Cromer et al!
📄 Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research
#PRS #SDoH
cell.com/ajhg/fulltext/S0002…
