Very excited to share our study spearheaded by A. Misra & @AniruddhPatelMD describing the development & validation of our clinical multi-CVD polygenic risk score test, including how it might inform CVD prevention sciencedirect.com/science/ar… @JACCJournals Any clinician can order this @MassGenBrigham @broadinstitute test today: massgeneralbrigham.org/en/re… We used an integrated framework we previously developed and described to maximize performance and score stability, and allow for versioning as genomic interpretation continually improves. cell.com/cell-genomics/fullt… nature.com/articles/s41467-0… The score was optimized in the nationwide @NIH @AllofUsResearch Program to enhance generalizability across communities, with validation in the @MassGenBrigham Biobank @amandajowell @buutrg @aklfahed @shaan_khurshid @patrick_ellinor @nialljlennon @HornsbyWhitney @EWkarlson

Our @AHAScience Policy Statement on Genetic and Genomic Testing in Cardiovascular Disease ahajournals.org/doi/10.1161/… @CircAHA "The goal of this policy statement is to articulate the position of the American Heart Association (AHA) in key areas of public policy concerning genetic (≥1 genes) and genomic (coding and non-coding genome) testing."

Terrific work from @iftikhar_kullo. *10y* fu MI-GENES trial (ahajournals.org/doi/10.1161/… @CircAHA) now shows that CAD PRS disclosure vs not on top of clinical risk disclosure for intermediate risk adults leads to reduction in MACE ahajournals.org/doi/10.1161/… @Circ_Gen #ACC25 Small trial that now requires confirmation across multiple sites with contemporary PRS and clinical risk scores. My editorial for the original MI-GENES report in 2016 ahajournals.org/doi/10.1161/… @CircAHA @PRSdiversity

Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w @AniruddhPatelMD demonstrates how successive score integration can improve accuracy & stability nature.com/articles/s41467-0… @NatureComms

Delighted to share our study by @tigerstatdoc with @aklfahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events ahajournals.org/doi/10.1161/… @Circ_Gen

Honored to work with @iftikhar_kullo & colleagues in @PRSdiversity advancing innovations and equity in genomic medicine via polygenic risk scores sciencedirect.com/science/ar… @AJHGNews primedconsortium.org/ @genome_gov

Current polygenic risk scores require binning of ancestry groups but we know ancestry is a continuum. Our study led by @Yunfeng_Ruan introduces DiscoDivas, a new generalizable PRS framework across the ancestry spectrum medrxiv.org/content/10.1101/… @medrxivpreprint @PRSdiversity

Fantastic @Nature News Feature by @AnilOza16- Why does heart disease affect so many young South Asians? Highlights our ambitious goals with @ourhealthstudy & others like @masala_study. nature.com/articles/d41586-0… 💜 ourhealthstudy.org/ 💜 @HeartDocSadiya @alka_kanaya @NammiKan