
🇺🇸🇩🇪 Claude Code Degenerate. Aerospace, Hardware investor @IndicatorFund. Former Head of Intl and Crypto @robinhoodapp . 出海 investor @plaudAI, @ManusAI
London
Joined August 2007
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Yes, AI is rapidly advancing mathematics (and theoretical physics problems that are essentially mathematical). Like Ramanujan’s notebooks, human mathematicians will spend months (years?) poring over the stream of papers that AI effortlessly generates, hoping to verify and understand them, probably until math itself (via Lean) becomes a branch of computer science like almost everything else.
However, after math and physics, there is still a next scientific frontier: chemistry, and especially biology and medicine.
I mean, it was already the frontier, but it’s the next one too. AI can crush deterministic math problems on the computer, but biomedicine is a highly empirical, noisy, multivariate, and yet often predictable domain.
Thus, AI radically increases our ambitions in biomedicine. All the omics data, all the messy literature, it can all be synthesized and analyzed in a flash. This is what the labs mean when they talk about curing all diseases. The tooling is available to take cracks at biomedical problems previously thought impossible.
Midjourney is doing this, Chan Zuckerberg is doing this, Anthropic is doing this, but there will be so much more.
Patrick retweeted
Replying to @straits_times
Why is everyone acting like this is a forest fire issue when its clearly annual burning of palm oil plantations, by companies domiciled IN Singapore.
Patrick retweeted
Interesting chart.🤔
The seventh edition of our Top 100 Consumer AI Apps is here.
New this time: a revenue leaderboard, alongside the usual web and mobile traffic rankings.
Three years ago we published the first edition. ChatGPT was #1, Claude was unranked, and the entire category was chatbots, image generators, and not much else.
In today's edition:
- ChatGPT still holds the throne, now with 1B+ monthly actives on mobile
- Claude has climbed to #3 on web with nearly 1B monthly visits
- The category has expanded to vibe coding (Lovable, Cursor, Replit), music (Suno), design (Figma), voice (ElevenLabs), video (Higgsfield, Kling), agents (Manus), and even hardware (Plaud)
Full breakdown from @omooretweets: a16z.news/p/top-100-consumer…
Patrick retweeted
Explaining the Catholic Church to Godless AI researchers:
Imagine a lab thats spent 2000 years working on alignment
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Twenty five years ago today, a 62 year old man with cancer in his bones walked 2,687 people out of the South Tower, and then he went back inside.
Rick Rescorla was born in Hayle, Cornwall in 1939. British Parachute Regiment in Cyprus at 18. Colonial police in Northern Rhodesia. Then he came to America, enlisted in the US Army in 1963, and in November 1965 he went into the Ia Drang Valley as a platoon leader with the 2nd Battalion, 7th Cavalry.
Hal Moore called him the best platoon leader he ever saw. His men called him Hard Core. He sang to them in the dark, Wild Colonial Boy in an Australian accent, because he had worked out that men who are singing are not men who are panicking. That is Rescorla on the cover of We Were Soldiers Once and Young, bayonet fixed.
Thirty five years later he was head of security for Dean Witter, later Morgan Stanley, in the South Tower of the World Trade Center.
In 1990 he brought in his old friend Dan Hill and the two of them walked the basement. He warned the Port Authority that the parking garage was wide open, that somebody could drive in a truck full of explosives, walk out and light it off. Nothing was done. Three years later the 1993 bomb went off about thirty feet from the spot he had flagged.
After that he told Morgan Stanley the towers were still a target and the next attack would come out of the sky. He wanted the firm to leave Manhattan. The lease ran to 2006, so they stayed. Twenty two floors of the South Tower, roughly 2,700 people.
So he drilled them. Every three months, everyone, no exceptions, down the stairwells two abreast while he stood there with a stopwatch. Traders pulling seven figures resented being marched down concrete stairs by a Cornishman with a clipboard. He kept doing it anyway.
8:46 a.m. The North Tower is hit. Port Authority comes over the South Tower loudspeakers and tells everyone the building is secure and to go back to their desks. Rescorla picks up a bullhorn and tells his people to get out.
He phones Dan Hill. "The dumb sons of bitches told me not to evacuate. They said it's just Building One. I told them I'm getting my people out of here."
9:03 a.m. The second plane hits the South Tower, floors 77 through 85. His people are already in the stairwells, moving exactly the way they had been drilled, and Rescorla is on the bullhorn singing to them. Cornish songs. A version of Men of Harlech he had rewritten for Cornwall. Men of Cornwall stop your dreaming, can't you see their spearpoints gleaming.
He called his wife Susan from the stairs. They had been married two and a half years, met jogging in New Jersey. He told her to stop crying, that he had to get these people out safely, and that if something happened to him he wanted her to know he had never been happier, that she made his life.
Someone told him to get out. He said, as soon as I make sure everyone else is out.
2,687 Morgan Stanley employees went home that day. Thirteen did not, and four of those were Rescorla and the men who stayed in the building with him: Wesley Mercer, Jorge Velazquez, Godwin Forde.
He was last seen on the 10th floor, walking up.
The South Tower fell at 9:59. They never found him.
Patrick retweeted
China just got 88% easier to visit
Now waiting for PayPal to drop their AI router 🤣
Traveling to China? Bring PayPal.
U.S. PayPal users can now use the PayPal app to make in-store QR code payments at Weixin Pay merchants across China through PayPal World — no new apps needed.
Learn more: paypalworld.com/us/personal/…
Patrick retweeted
Replying to @araseb_
Sarah, I have studied this for decades in advising startups. It comes down to a disrespect for sales. From marketing to sales people. Many “feel” that the products they make, if made “right” sell themselves. It is not only the downfall of countless companies it assures great products are less successful. It gets worse when VCs encourage this thinking. Great and creative marketing would absolutely serve any company, no matter the product. An example of those that do market, speak to existing users. The recent ads on YouTube by AI companies are speaking to the 8% of the world that know them missing the rest. So this is unlikely to change anytime soon.
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The Blue Zones—places where people supposedly live past 100 at extraordinary rates—aren't real.
A 🧵 on what went wrong: bad record keeping, pension fraud, and lots of money.
Everyone in the Valley has a take on whether China is winning AI, robotics, and biotech. Almost nobody understands how the capital works
Notes from meeting China's tier-1 investors and founders on how their venture ecosystem actually works.
4 PEOPLE JUST BUILT A MULTI-AGENT SYSTEM THAT OUTSCORED CODEX AND CLAUDE CODE ON REAL WORK BENCHMARKS.
The part that matters even more:
D1 decides which agent acts
which stays quiet
and when a human should step in
This feels less like a chatbot and more like a company.
🤝 Paid partnership
Introducing Offloop!
We're a team of four. Today our multi-agent harness hit state of the art on GDPval, ahead of Claude code and Codex across jobs that pay $2.4 trillion a year in the US.
Offloop gives every knowledge worker what the Fortune 500 spends billions on: a high-performing agent army that runs itself and grows the business.
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BREAKING: The Trump administration is offering $17.5 billion in low-cost loans to help finance the construction of 10 new Westinghouse AP1000 nuclear reactors across the U.S.
































