Structural biology and biochemistry of RNA virus replication proteins, at Colorado State University.
Fort Collins, CO
Joined March 2010
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Peersen Lab retweeted
The polymerase of #coronavirus #SARSCoV2 can adopt an alternative structure: an antiparallel dimer with only one nsp8 that may bind only one nsp13. We speculate the dimer facilitates template switching and synthesis of subgenomic viral #RNA.
Manuscript: biorxiv.org/content/10.1101/…
Peersen Lab retweeted
Our paper describing the #coronavirus RNA polymerase structure is online. The nsp8 extensions contact RNA far away from the active site, apparently enabling processive replication of the very long #SARSCoV2 genome.
Publication: nature.com/articles/s41586-0…
PR: mpibpc.mpg.de/17275755/pr_20…
Peersen Lab retweeted
Thanks to A Shannon F. Ferron and the Canard team: Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites sciencedirect.com/science/ar…
Peersen Lab retweeted
Due to public health concerns regarding the COVID-19 pandemic, ASV 2020 has been cancelled. Please see our full statement here: asv.org/asv2020stmt
Peersen Lab retweeted
#ASV2020 Program and abstract submission are now live at ASV2020.com. Coming/opening soon: registration, residence hall registration, travel award and ASVCares applications, and *NEW* for 2020, onsite childcare. #LoveVirology