Unlock the promise of safe, accessible, powerful reprogenetics. Independent nonprofit. Book on strong reprogenetics: https://nitter.gq/t.co/GBOjkvWsy3 Run by @tsvibt
Berkeley, CA
Joined December 2024
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Pretty curious about this too. Most of the objections I see on twitter end up being about the destruction of embryos. What if we genomically vector stem cells, turn them into gametes, and then make a single embryo at a time that we try to implant?
nitter.gq/tracewoodgrains/status…
Should polygenic embryo scores be kept from parents because probability is confusing? Dr. Jonathan Anomaly, co-founder of Herasight, spoke at Reproductive Frontiers 2026 about enabling informed choice that's better than government control.
YouTube link in reply. ⬇️
Timestamps:
00:00:00 Intro
00:01:36 Informed choice vs. paternalism
00:02:59 Genetic testing laws in Europe
00:06:23 Reasons to restrict testing
00:08:07 Decision fatigue and the paradox of choice
00:14:31 Complex, probabilistic choices are everywhere
00:17:57 How companies can promote informed choice
00:19:54 Pleiotropy
00:29:10 Presenting results; closing thoughts
00:33:23 Q&A
This is great news. When parents ask "How can I give my future child a life they'll love?", one of the top concerns is the child's happiness and wellbeing. Cognitive traits, especially other than intelligence, are generally hard than diseases to predict with genetics in part because they are hard to define and measure consistently. This research is a substantial step in the right direction.
nitter.gq/_twolfram/status/21173…
Should we correct disease mutations before a child is born? Dr. Eriona Hysolli, formerly @ Church lab & Colossal Bio, spoke at Reproductive Frontiers 2026 about why embryo-stage prevention of severe genetic disease deserves a path forward.
YouTube link in reply.⬇️
Timestamps:
00:00:00 Intro
00:01:07 Why embryo editing, and why now
00:03:18 The toolkit: from CRISPR-Cas9 to base editors
00:06:07 Multiplex editing, recoding, and the mammoth mouse
00:09:37 Human embryo editing with CRISPR-Cas9, 2015-2020
00:16:23 Base editors in human embryos
00:19:15 Why pursue prevention
00:23:11 Precedents: IVF and mitochondrial replacement
00:26:39 Regulation in the US and worldwide
00:30:11 Concluding remarks
00:31:56 Q&A
Thanks to Dr. Eriona Hysolli for the talk!
YouTube link:
youtube.com/watch?v=BdYVCf3l…
Can we grow a human blastocyst from stem cells, and watch it implant? Prof. Jun Wu of UT Southwestern spoke at Reproductive Frontiers 2026 about creating embryo-like structures that can implant into endometrial organoids.
YouTube link in reply. ⬇️
Timestamps:
00:00:00 Intro
00:00:46 Why build embryo models from stem cells
00:06:28 Making human blastoids
00:09:58 Implantation on an endometrial organoid chip
00:13:10 Implantation failure: patient cells and a drug screen
00:15:49 Assembled blastoids: trophectoderm via YAP
00:21:24 Mouse-human chimeras implant on the wrong side
00:23:44 FGF signaling sets the implantation side
00:27:04 Q&A
Reprogenetics Institute retweeted
Exciting talk from @PaternaBio. If they can mature sperm in the lab, men with severe infertility could have biological kids.
The same tech could let us genetically screen sperm before conception, making embryo screening far more powerful.
Kudos to @nucleusgenomics for sponsoring this IRB study testing whether screening embryos based on polygenic risk scores will decrease implantation rates compared to screening only on embryo morphology!
nitter.gq/TreffDNA/status/211011…
Reprogenetics Institute retweeted
Today we launch NeuroRisk, the first embryo test for autism and schizophrenia that looks for mutations in evolutionarily important genes.
These mutations are individually rare but over 10% of people carry at least one mutation in this class.
Hi Kian, great to see more IQ PGS research! A few things:
* You say "optimize embryo DNA for 14 IQ points". I think you're referring to the expected spread for 10 embryos, but this is a misleading way of stating these results. Expected gain is the logical number to share. (To be clear, I think that Herasight sometimes summarizes things in a similarly unhelpful way, which should also be called out.) Further, the relevant number is achievable births; 10 achievable births is quite optimistic (and/or expensive) for most people at the moment.
* You say in the context of the IQ model that "The models were trained on 1,000,000+ people", but that contradicts the 500k number from the paper; you may be referring to the data for the height and BMI models, but that doesn't match the context.
* You say "validated across 40,000+ siblings"; that's not for IQ though, right?
* You say "Parents across the world now have the choice to substantially increase their child’s intelligence."---but there are quite substantial dropoffs for many ancestry groups for PGSes trained on mainly European-ancestry data. This is a great aspiration, but it overstates the current state of things.
nitter.gq/KianSadeghi5/status/21…
AI is rapidly getting smarter.
Now, humanity can too.
Today, @nucleusgenomics is announcing Vitruvian, our newest set of genetic optimization models.
Vitruvian’s intelligence model can optimize embryo DNA for 14 IQ points — nearly a standard deviation.
The models were trained on 1,000,000+ people, validated across 40,000+ siblings, and used more than 7 million genetic markers.
In Superintelligence, Nick Bostrom proposed genetic optimization as a key way for humanity to keep pace with rapidly advancing AI.
Bostrom’s vision is no longer theoretical.
Genetic optimization, like AI, has followed a scaling law: as datasets have grown, so have model capabilities. This trend will continue.
Parents across the world now have the choice to substantially increase their child’s intelligence.
And the next generation can choose to do the same.
AI is no longer the only intelligence that will compound.
Humanity can now direct its own evolution.
[Evaluating grants... 🔄]
[Onboarding operations & policy lead... 🛠️]
[Chromosome selection report... ⏳]
[3rd party PGS claim validator (stalled).... 🚧]
[Intelligence tail report... 🐌]
People are in favor of reprogenetics to decrease disease risks. Other traits are more controversial, but the main use of reprogenetics is not opposed by the public, it is widely and strongly supported.
Source: pewresearch.org/science/2020…
An American sample, from link.springer.com/article/10… :
The Berkeley Genomics Project is hiring for operations lead. Other roles include research & writing, policy & lobbying, and media. If you know anyone competent and very motivated to support the emerging sector of reprogenetics, send them this please! Links ⬇️
Apply with this form: airtable.com/app7J6q9B0tBrmQ…
Announcement post:
lesswrong.com/posts/6AiC8ppR…
(and on EA forum: forum.effectivealtruism.org/…)