Rheumatologist | MSK Ultrasound | 🇲🇽
Guadalajara , Jalisco
Joined March 2010
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Klaudia Gomez retweeted
Scary IPAF
IPAF describes patients who have ILD plus clinical, serologic, or morphologic features of autoimmunity but who do not meet criteria for a defined connective tissue disease. The 2015 ERS/ATS criteria proposed IPAF as a research classification, not a distinct disease, intended to create more uniform cohorts for study (Fischer et al., European Respiratory Journal, 2015).
buff.ly/xv1KeuW
Klaudia Gomez retweeted
Korean retrospective study compared NIDDM pts Rx w/ SGLT2 inhibitor (n 552,065) vs sulfonylurea (1,480,092) showed SGLT2 inhibitors were assoc w/ a signif 11% lower risk of incident autoimmune rheumatic disease (HR 0.89). Diff of −6.50 per 100K PYs over median ~9 mos F/U. buff.ly/7TqM4CT
Klaudia Gomez retweeted
Nailfold Capillaroscopy correlated w/ cardiac ECHO in Systemic Sclerosis. NFC & ECHOs studied in 30 SSc pts. Systolic & diastolic dysfunction most common in late SSc NFC patterns. Cardiac dysfunction seen w/ low capillary density, avascular areas, cap neoangiogenesis buff.ly/EUIXnIK
Klaudia Gomez retweeted
Full read review of Catastrophic Antiphospholipid Syndrome (CAPS) bit.ly/3Sg2xaE
Klaudia Gomez retweeted
Many treatments for seronegative #spondyloarthropathy. And #psoriatic #arthritis But what to choose and when and for whom?
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Klaudia Gomez retweeted
SGLT2 inhibitor (empagliflozin) given in a lupus mouse (MRL/lpr) model showed a renoprotective effect suggesting the value of non-immunosuppressive therapies to improve renal function. Showed less -dsDNA Abs, proteinuria, renal nephritis damage bit.ly/3DKMv0E
Klaudia Gomez retweeted
Data from 'real-world' experience suggest that Nintedanib could be helpful for patients who start treatment after presenting with ILD acute exacerbation decreasing the occurrence of recurrent exacerbations and prolonging survival.
#pulmonaryfibrosis
nature.com/articles/s41598-0…
Klaudia Gomez retweeted
Revisión narrativa 📚 de los tratamientos disponibles para artritis psoriásica por dominios y enfermedades asociadas. Gran trabajo de @drgizemayan @Dr_AndreRibeiro @BetulMacit @ProftDr @GrappaO 👏🏻 Enlace abierto 🔓 pdf.sciencedirectassets.com/…
Klaudia Gomez retweeted
Tofacitinib May Reduce Interstitial Lung Disease Risk in RA
Tofacitinib (Xeljanz) in patients with RA stood out among several other biologic and targeted sDMARDs when it came to the incidence of ILD, a retrospective cohort study showed.
bit.ly/3Zm4Jxw
Klaudia Gomez retweeted
Peripheral Blood Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Review pubmed.ncbi.nlm.nih.gov/3685…
Klaudia Gomez retweeted
#MyositisPearl 8: A subtype of #Myositis is Immune Mediated Necrotizing Myopathy (#IMMM). It is about 20% of all #IIM. It is associated with anti-SRP (1/3rd) & anti-HMGCR (1/3rd) Myositis Antibody. 1/3rd Ab negative. Leads to severe muscle weakness, very high CK and disability.
Klaudia Gomez retweeted
Review on scleromyositis:
- No validated definition.
- Aldolase is more frequently elevated than CK.
- Antibodies: anti-PM/Scl, -Ku, -U1-RNP, -U3-RNP, - RuvBL1/2, -SMN
- Muscle biopsy: Vasculopathy, fibrosis, myofiber necrosis.
- Be careful with steroids and SSc renal crisis.
Klaudia Gomez retweeted
#ClinicalPearl #MedEd #MedTwitter Elderly woman with long-standing hand pain. What do you think? hint look at L2nd MCP. Bonus - what about bone quality
Klaudia Gomez retweeted
Our analysis of myositis specific and associated antibodies (MSA/MAA) detected by line blot in our Immunology lab between 2018 -2020
- 130 samples ➡ 164 MSA/MAA.
- 51.8% were classified as clinical true + (CTP) (associated to their disease) and 48.2% as clinical false + (CFP).
Klaudia Gomez retweeted
More evidence on JAK inhibitors in dermatomyositis:
- Open label. 16 patients. 88% cutaneous, 56% muscle, 44% both.
- Improvement in CDASI ➡ 27 (basal) ➡ 14 (3 months) ➡ 5 (1.8 years).
- 1 died (MDA5 with ILD), 2 relapsed (muscle disease).
pubmed.ncbi.nlm.nih.gov/3635…
Klaudia Gomez retweeted
Clinical phenotypes in ANCA asociated interstitial lung disease:
- 100 patients. Retrospective study.
- 3 groups: MPA, unclassifiable vasculitis, IPF (ANCA+).
- Unclassifiable vasculitis tended to have a better survival
Klaudia Gomez retweeted
#Methotrexate does *not* cause liver fibrosis
pubmed.ncbi.nlm.nih.gov/3670…
#RA #psoriaticarthritis #rheumatoidarthritis
