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👉Heterogeneity in Lipoprotein(a) Profile Changes Across the Menopausal Transition ☝️New data challenge the concept of Lp(a) as a truly “once-in-a-lifetime” measurement—particularly across menopause. 1️⃣ In 4,562 women from the UK Biobank, overall changes in Lp(a) over ~4 years were modest. 2️⃣ Among women with baseline Lp(a) 75–125 nmol/L, those transitioning through menopause showed a median increase of 34.9 nmol/L—~4× greater than women remaining pre- or postmenopausal. 3️⃣ 56.4% of these women crossed the clinically relevant ≥125 nmol/L threshold after menopause, versus ~29% in the comparison groups. 4️⃣ After adjustment for age and baseline Lp(a), menopausal transition was associated with a 2.27-fold higher risk of crossing that threshold. ☝️Take-home message: Lp(a) is largely genetically determined, but not necessarily biologically static. Repeat measurement after menopause may be particularly relevant when premenopausal Lp(a) is in the intermediate range 🔗🔓 academic.oup.com/eurjpc/adva… @society_eas