Check-out our new publication in @ScienceAdvances where we decipher at the structural and functional levels how PAXX and XLF can interact simultaneously with Ku to promote DNA end synapsis and proficient #NHEJ #DNA_repair doi.org/10.1126/sciadv.adg28…
Awesome presentation from @StephanHacker2 this Morning at the Toulouse JCBS meeting "Covalent inhibitors for the Proteome-wide identification of new druggable targets for antibiotics"
These lipids are prodrugs bioactivated by HSD17B11-mediated enantiospecific oxidation into protein-reactive electrophiles. These species trigger an acute proteotoxic stress by blocking the Protein Quality Control mechanisms.
New insights into #DNA_repair - check out our @NAR_Open publication describing how the ATM kinase antagonizes toxic #NHEJ by promoting Ku release from seDSBs through DNA-PKcs phosphorylations academic.oup.com/nar/advance…
G4_ligands induce transcription associated DSBs. Here we show using an unbiased approach that #DNA_topoisomerase II alpha (#TOP2A) catalytic activity is the main source of these DSBs while #TOP1 antagonizes this shorturl.at/eBHUZ
Now in #bioRxiv : “Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands” - shorturl.at/eBHUZ - #G4 - First #preprint from the lab.
Looking for an in-depth review on the Ku complex, a key hub for assembly of NHEJ #DNA_repair factors. Here it is: bit.ly/31uIYOc Free of access for 6 weeks.
#HarryPotter style #WesternBlot
Lightnings appeared where I touched the film (probably electrostatic discharges)
Got this back in @SPJacksonGroup. Time to share it... @WB_Facts
Powerful approach to identify small molecules targeting essential proteins/genes. Here used in M. #tuberculosis, but could be extended to other organisms or used to identify drug mechanism of action go.nature.com/2WU5oer
