Pharmacological tinkerer and PhD. Interests include Neuroscience, human brain models and Sci-fi! Working on Autism Spectrum Disorder at UZH. Views own.
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ALT From microarrays to spatial transcriptomics: a decade-long Oxford–Tokyo collaboration maps the developing brain’s earliest cortical neurons We are delighted to share our paper, “Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons,” published in the Journal of Anatomy by Hitomi Achiwa Chiaki Ohtaka-Maruyama and colleagues at the Tokyo Metropolitan Institute of Medical Science and the University of Oxford. Subplate neurons are among the first neurons to mature in the developing cerebral cortex. Despite their importance, the diversity of these cells—and the rapid changes in their molecular identities during embryonic development—has remained difficult to resolve. Our study combined three generations of transcriptomic technology: bulk microarray profiling, single-cell RNA sequencing and Visium spatial transcriptomics. By studying two complementary reporter mouse lines, Lpar1-EGFP and NeuroD1-CreERT2, we identified overlapping but distinct subplate populations.
ALT Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells we now show that exogenous neuroserpin is protective agains mild neonatal HIE (https://doi.org/10.3390/cells14231840).
ALT Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity. Cortical subplate neurons have transient secretory function during development and one of the protein they secrete in mouse and human is neuroserpin encoded by the serpini1 gene (https://doi.org/10.3389/fnins.2015.00100; https://doi.org/10.1111/joa.12931). We proposed that subplate might influence cortical circuit formation through a transient secretory function. We have previously demonstrated that exogeneous neuroserpin is protective agains ER stress and hypoxia/ischaemia in adult (DOI: 10.4103/NRR.NRR-D-24-00044). Recent work from Onoda et al. suggests that the brain specific neuroserpin is also a sensitive indicator for abnormal brain development in mild fetal growth restriction DOI: 10.1016/j.isci.2025.113237). In the recent Special Issue of Cells we now show that exogenous neuroserpin is protective agains mild neonatal HIE (https://doi.org/10.3390/cells14231840).
ALT Inhibitory neurons co-stained with SCGN and PAX6.
ALT Scientist using a microscope next to an image of cells, with text stating 'NIH establishes nation's first dedicated organoid development center to reduce reliance on animal modeling.' Laboratory glassware also shown.
