Author of Eat Shit & Prosper. Founder of Constellation Bio. Giving people back the parts of themselves they've lost. https://nitter.gq/t.co/eMsPVMDkjn
Berkeley, CA
Joined June 2021
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ɪ ᴄᴏᴍᴘʀɪsᴇ.
I've always said that I'll get a tattoo when I hear, or see, or think of something that I am compelled to have etched into my skin forever. I don't know if this quite does it, but I think it's the closest thing so far.
I've this take forever, that we can have effective single-payer healthcare if we just get 3-way marriages legalized and all pile onto the health insurance of one National Zaddy
Never been prouder to be a nonlongevity freak
If they dared, biohacking bros who seek to defy aging could try a simple, time-tested method: castration.
Removing the testicles extends male life span across many mammalian species, including humans. But a research team exploring this effect has now found the surgical procedure doesn’t have to be performed early in life to boost longevity, as scientists had assumed.
In a new preprint, the group reports that neutering older male mice lengthens their lives by more than 30%, upending prevailing ideas of how the testes influence aging.
Learn more: scim.ag/4eMYMV1
ALT Castration extends life span, but in a surprising way, mouse study suggests
"The Singularity is coming for Biology," he says.
I can't wait for it to meet The Multiplicity.
The rest of those doors represent human inventions. Simplicity is a design constraint in all of them. They're made to be understandable.
Stephen Skolnick retweeted
terry tao: imagine, if you will, a petrifying situation. you have produced a very effective drug, but you do not know how it works. do you trust the drug? now, this is just a hypothetical, but—
drug developers:
If Tolkeinian elves kept humans as pets, we'd probably end up giving them a disease.
I say this because Fusobacterium, a core component of the healthy canine gut microbiome, is very reliably associated with colorectal cancer.
I saw a post years ago positing that to dogs humans are like elves, immortal and unchanging. It reckoned that greatest honor a dog could achieve was to be there to ease a human’s passing, not just because it was an event so rare that generations of dogs lived and died never even seeing them age, but in recognition of the many ancestors that the human had cared for during their long life.
"Let he who is without sin..."
But seriously, this guy's been on his beat—that the pyramids and similar ancient-megalithic structures were poured rather than carved—for YEARS. He is obviously correct. But he makes everyone who did a PhD in Speculative Egyptology look the fool.
🧵 Cast stones? Come on!
"Where are the molds? And why is every single stone a different shape and size?"
I've been asked these two questions about twenty-eight thousand times, and I've answered them at least as often. It happens every time someone looks at a polygonal megalithic wall in Peru, Japan, Greece, or anywhere else megalithic walls stand. Apparently my patience is infinite, because here I am, summing it all up for the twenty-eight-thousand-and-first time.
The observation itself is fine: there really are no two identical stones in these walls, and "you can't slip a razor blade into the joints", as people who DON'T know the subject keep repeating.
The conclusion they draw, though, is a work of art: according to the critics, the stones can't be artificial because they're not identical. 😊
Hats off, you rarely see a logical backflip like that live :-)
1/7
Come to Lighthaven Oct 30 - Nov 1 for @AvalonInst's Avalon Exposition; I'll be giving a lecture series on the origins of a variety of chronic illnesses, along with some musings on the philosophical implications of the new science of the microbiome.
People need new grounds for sharing art and thought. The Avalon Exposition is ours: three days of exuberance for anything touching the human condition, from military history to music to the microbiome.
Some amazing work will be there. Bring yours!
avalon.institute/exposition/…
Another great example of how "consensus" science is just whatever major corporations decide. Try to update the Wikipedia article on any drug or herbal remedy and—even if you're citing legitimate studies—you'll have your edits reverted lickety-split as "not MEDRS"
This is certainly the most consequential paper published in child and adolescent psychiatry for the last few years. It shows that the meta-analyses that current child psychiatry guidelines rely on to recommend fluoxetine for depression were skewed by an unbelievable trial (n=40) in Iran which found an effect 15 times larger than the average.
When this trial is removed all meta-analyses find the same as a recent Cochrane analysis which found 'small and unimportant differences.'
The flawed meta-analyses by Zhou and @cipriani in the @TheLancet and Lancet Psychiatry need to be corrected.
And guideline committees need to update their guidance in the context of the harms of these drugs including withdrawal effects, sexual effects and agitation/akathisia and suicidality in a minority of youths exposed to them.
Link below
Other fun facts: I have it on good authority that @EliLillyandCo reran their pivotal prozac trial—the one it got approved on—in Japan a few years later and found no significant improvement in depression. Whoops!
